AutismKB 2.0

Annotation Details for NPPA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NPPA ( ANF,ANP,ATFB6,CDD-ANF,PND )
Gene Full Name: natriuretic peptide precursor A
Band: 1p36.22
Quick LinksEntrez ID:4878; OMIM: 108780; Uniprot ID:ANF_HUMAN; ENSEMBL ID: ENSG00000175206; HGNC ID: 7939
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005634IEA-nucleus-
GO:0042629IEA-mast cell granule-
GO:0043234IDA-protein complex16870210
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005102IDA-receptor binding1672777
GO:0005102IPI-receptor binding1660465
GO:0005184IMP-neuropeptide hormone activity19646991
GO:0005515IPI-protein binding25416956
GO:0051428IEA-peptide hormone receptor binding-
GO:0071855IMP-neuropeptide receptor binding19646991
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0003085IEA-negative regulation of systemic arterial blood pressure-
GO:0006182IDA-cGMP biosynthetic process1672777
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006457IDA-protein folding16870210
GO:0007168IDA-receptor guanylyl cyclase signaling pathway1672777
GO:0007218IDA-neuropeptide signaling pathway19646991
GO:0007565ISS-female pregnancy-
GO:0008217IDA-regulation of blood pressure6230082
GO:0010460IMP-positive regulation of heart rate19646991
GO:0014898IEA-cardiac muscle hypertrophy in response to stress-
GO:0030308IEA-negative regulation of cell growth-
GO:0032868IEA-response to insulin-
GO:0035994TAS-response to muscle stretch15276478
GO:0044267TAS-cellular protein metabolic process-
GO:0050880IEA-regulation of blood vessel size-
GO:0060372IMP-regulation of atrial cardiac muscle cell membrane repolarization19646991
GO:0060452IMP-positive regulation of cardiac muscle contraction19646991
GO:0061049IEA-cell growth involved in cardiac muscle cell development-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:1901841ISS-regulation of high voltage-gated calcium channel activity8301666
GO:1902261IDA-positive regulation of delayed rectifier potassium channel activity8301666
GO:1902514ISS-regulation of calcium ion transmembrane transport via high voltage-gated calcium channel8301666
GO:1903766IDA-positive regulation of potassium ion export across plasma membrane8301666
GO:1903779TAS-regulation of cardiac conduction-
GO:1903815IEA-negative regulation of collecting lymphatic vessel constriction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NPPAEPB4110834912542678 Reconstituted Complex
NPPAEPB4111093812542678 Reconstituted Complex
NPR2NPPA1109421309330 Reconstituted Complex
NPR2NPPA1109381309330 Reconstituted Complex
NPR3NPPA1109381309330 Reconstituted Complex
NPR3NPPA1109431309330 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97367
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-95'