Gene Symbol:	ATP2A2 ( ATP2B,DAR,DD,DKFZp686P0211,FLJ20293,FLJ38063,MGC45367,SERCA2 )
Gene Full Name:	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Band:	12q24.11
Quick Links	Entrez ID:488; OMIM: 108740; Uniprot ID:AT2A2_HUMAN; ENSEMBL ID: ENSG00000174437; HGNC ID: 812
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005654	IDA	-	nucleoplasm	-
GO:0005783	IDA	-	endoplasmic reticulum	16081076
GO:0005789	IDA	-	endoplasmic reticulum membrane	11402072
GO:0005789	TAS	-	endoplasmic reticulum membrane	-
GO:0005887	TAS	-	integral component of plasma membrane	2844796
GO:0012506	IEA	-	vesicle membrane	-
GO:0016020	IDA	-	membrane	22375059
GO:0016529	IDA	-	sarcoplasmic reticulum	12804600
GO:0031095	TAS	-	platelet dense tubular network membrane	-
GO:0031234	IEA	-	extrinsic component of cytoplasmic side of plasma membrane	-
GO:0033017	TAS	-	sarcoplasmic reticulum membrane	19095005
GO:0043234	IEA	-	protein complex	-
GO:0048471	IEA	-	perinuclear region of cytoplasm	-
GO:0097470	IEA	-	ribbon synapse	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005388	IDA	-	calcium-transporting ATPase activity	16402920
GO:0005388	TAS	-	calcium-transporting ATPase activity	-
GO:0005509	IDA	-	calcium ion binding	16402920
GO:0005515	IPI	-	protein binding	17526652
GO:0005524	IEA	-	ATP binding	-
GO:0019899	IPI	-	enzyme binding	21903937
GO:0031775	IEA	-	lutropin-choriogonadotropic hormone receptor binding	-
GO:0044548	IPI	-	S100 protein binding	12804600
GO:0086039	IC	-	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	16402920
GO:0086039	ISS	-	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	-
GO:0086039	TAS	-	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	22679139

GO ID	Evidence	Qualifier	GO_term	References
GO:0002026	IEA	-	regulation of the force of heart contraction	-
GO:0006984	IEA	-	ER-nucleus signaling pathway	-
GO:0006996	IEA	-	organelle organization	-
GO:0007155	TAS	-	cell adhesion	10080178
GO:0008544	TAS	-	epidermis development	10080178
GO:0010460	TAS	-	positive regulation of heart rate	22679139
GO:0010882	IEA	-	regulation of cardiac muscle contraction by calcium ion signaling	-
GO:0014883	IEA	-	transition between fast and slow fiber	-
GO:0014898	IEA	-	cardiac muscle hypertrophy in response to stress	-
GO:0032469	IDA	-	endoplasmic reticulum calcium ion homeostasis	16402920
GO:0032470	IDA	-	positive regulation of endoplasmic reticulum calcium ion concentration	16402920
GO:0033292	IEA	-	T-tubule organization	-
GO:0034220	TAS	-	ion transmembrane transport	-
GO:0034599	IEA	-	cellular response to oxidative stress	-
GO:0034976	ISS	-	response to endoplasmic reticulum stress	-
GO:0045822	IEA	-	negative regulation of heart contraction	-
GO:0055119	IEA	-	relaxation of cardiac muscle	-
GO:0070296	TAS	-	sarcoplasmic reticulum calcium ion transport	19095005
GO:0070588	IDA	-	calcium ion transmembrane transport	16402920
GO:0086036	IC	-	regulation of cardiac muscle cell membrane potential	16402920
GO:0086036	ISS	-	regulation of cardiac muscle cell membrane potential	-
GO:0086036	TAS	-	regulation of cardiac muscle cell membrane potential	22679139
GO:0098909	ISS	-	regulation of cardiac muscle cell action potential involved in regulation of contraction	-
GO:0099132	IEA	-	ATP hydrolysis coupled cation transmembrane transport	-
GO:1903233	IEA	-	regulation of calcium ion-dependent exocytosis of neurotransmitter	-
GO:1903515	IDA	-	calcium ion transport from cytosol to endoplasmic reticulum	16402920
GO:1903779	TAS	-	regulation of cardiac conduction	-
GO:1990036	IC	-	calcium ion import into sarcoplasmic reticulum	16402920
GO:1990036	ISS	-	calcium ion import into sarcoplasmic reticulum	-

Gene Symbol	Interactant	Interaction ID	References	Description
PLN	ATP2A2	111365	10809745 11854448 12032137	Affinity Capture-Western; Reconstituted Complex
PLN	ATP2A2	106978	10809745 11854448 12032137	Affinity Capture-Western; Reconstituted Complex
SLN	ATP2A2	112474	12032137	Affinity Capture-Western
SLN	ATP2A2	106978	12032137	Affinity Capture-Western
S100A1	ATP2A2	112179	12804600	Affinity Capture-Western
S100A1	ATP2A2	106978	12804600	Affinity Capture-Western
PTP4A3	ATP2A2	116327	17353931	Affinity Capture-MS
PTP4A3	ATP2A2	106978	17353931	Affinity Capture-MS
HGS	ATP2A2	114593	19019082	Reconstituted Complex
HGS	ATP2A2	106978	19019082	Reconstituted Complex

AutismKB 2.0

Annotation Details for ATP2A2