AutismKB 2.0

Annotation Details for SLC11A2


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Basic Information Top
Gene Symbol:SLC11A2 ( DCT1,DMT1,FLJ37416,NRAMP2 )
Gene Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Band: 12q13.12
Quick LinksEntrez ID:4891; OMIM: 600523; Uniprot ID:NRAM2_HUMAN; ENSEMBL ID: ENSG00000110911; HGNC ID: 10908
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15880641
GO:0005737IDA-cytoplasm11891802
GO:0005739IDA-mitochondrion-
GO:0005741IEA-mitochondrial outer membrane-
GO:0005765IDA-lysosomal membrane10751401
GO:0005769IDA-early endosome15880641
GO:0005773IMP-vacuole17932044
GO:0005886IMP-plasma membrane11891802
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane25491917
GO:0005887IMP-integral component of plasma membrane25326704
GO:0009986IEA-cell surface-
GO:0016020IDA-membrane19946888
GO:0016324IDA-apical plasma membrane15880641
GO:0031410IDA-cytoplasmic vesicle15880641
GO:0031526ISS-brush border membrane-
GO:0031902IDA-late endosome membrane10751401
GO:0045177IDA-apical part of cell15880641
GO:0045178IDA-basal part of cell15880641
GO:0048471IDA-perinuclear region of cytoplasm10751401
GO:0055037IDA-recycling endosome15880641
GO:0070826IDA-paraferritin complex11842004
GO ID Evidence Qualifier GO_term References
GO:0005375IDA-copper ion transmembrane transporter activity12734107
GO:0005381TAS-iron ion transmembrane transporter activity-
GO:0005384IDA-manganese ion transmembrane transporter activity17293870
GO:0005515IPI-protein binding15880641
GO:0015078IEA-hydrogen ion transmembrane transporter activity-
GO:0015086IDA-cadmium ion transmembrane transporter activity12662899
GO:0015087IEA-cobalt ion transmembrane transporter activity-
GO:0015093IDA-ferrous iron transmembrane transporter activity12734107
GO:0015093NAS-ferrous iron transmembrane transporter activity9990067
GO:0015094IDA-lead ion transmembrane transporter activity12127992
GO:0015295IDA-solute:proton symporter activity17109629
GO:0015639IMP-ferrous iron uptake transmembrane transporter activity25491917
GO:0046870IDA-cadmium ion binding25326704
GO:0046915IDA-transition metal ion transmembrane transporter activity25326704
GO ID Evidence Qualifier GO_term References
GO:0006783IEA-heme biosynthetic process-
GO:0006824IEA-cobalt ion transport-
GO:0006825IDA-copper ion transport12734107
GO:0006828IDA-manganese ion transport17293870
GO:0006879TAS-cellular iron ion homeostasis-
GO:0007611IEA-learning or memory-
GO:0010039IEP-response to iron ion12734107
GO:0015684IDA-ferrous iron transport12734107
GO:0015692IDA-lead ion transport12127992
GO:0035434IEA-copper ion transmembrane transport-
GO:0048813IEA-dendrite morphogenesis-
GO:0048821IEA-erythrocyte development-
GO:0060586IMP-multicellular organismal iron ion homeostasis15459009
GO:0070574IDA-cadmium ion transmembrane transport12662899
GO:0070627NAS-ferrous iron import9990067
GO:0071421IEA-manganese ion transmembrane transport-
GO:1902600IEA-hydrogen ion transmembrane transport-
GO:1903874IEA-ferrous iron transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NDFIP2SLC11A212007418776082 Affinity Capture-Western
NDFIP2SLC11A211095018776082 Affinity Capture-Western
NDFIP1SLC11A211095018776082 Affinity Capture-Western
NDFIP1SLC11A212329618776082 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SLC11A2-646 G/A, INT2 A/G, rs149411, rs407135 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1345279
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-021115-1'