AutismKB 2.0

Annotation Details for NTRK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NTRK1 ( DKFZp781I14186,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 1
Band: 1q23.1
Quick LinksEntrez ID:4914; OMIM: 191315; Uniprot ID:NTRK1_HUMAN; ENSEMBL ID: ENSG00000198400; HGNC ID: 8031
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005768TAS-endosome-
GO:0005769ISS-early endosome-
GO:0005770ISS-late endosome-
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane1281417
GO:0009986IEA-cell surface-
GO:0030424IEA-axon-
GO:0030425IEA-dendrite-
GO:0031901IEA-early endosome membrane-
GO:0031902IEA-late endosome membrane-
GO:0043025IEA-neuronal cell body-
GO:0043234ISS-protein complex-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity2927393
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity15488758
GO:0004714IMP-transmembrane receptor protein tyrosine kinase activity1281417
GO:0005004IEA-GPI-linked ephrin receptor activity-
GO:0005166IEA-neurotrophin p75 receptor binding-
GO:0005515IPI-protein binding10490030
GO:0005524IEA-ATP binding-
GO:0010465IDA-nerve growth factor receptor activity15488758
GO:0010465IMP-nerve growth factor receptor activity1281417
GO:0019900IEA-kinase binding-
GO:0042803IDA-protein homodimerization activity1281417
GO:0043121TAS-neurotrophin binding9290260
GO:0048406IDA-nerve growth factor binding1281417
GO ID Evidence Qualifier GO_term References
GO:0000186TAS-activation of MAPKK activity-
GO:0001934TAS-positive regulation of protein phosphorylation19036963
GO:0006468IDA-protein phosphorylation15488758
GO:0007018TAS-microtubule-based movement-
GO:0007411IEA-axon guidance-
GO:0007568IEA-aging-
GO:0007611IEA-learning or memory-
GO:0007623IEA-circadian rhythm-
GO:0008285IDA-negative regulation of cell proliferation15488758
GO:0009314IEA-response to radiation-
GO:0010623ISS-programmed cell death involved in cell development-
GO:0010976IDA-positive regulation of neuron projection development15488758
GO:0014823IEA-response to activity-
GO:0018108IDA-peptidyl-tyrosine phosphorylation2927393
GO:0021553IEA-olfactory nerve development-
GO:0030183IEA-B cell differentiation-
GO:0031667IEA-response to nutrient levels-
GO:0038083IMP-peptidyl-tyrosine autophosphorylation1281417
GO:0038180IMP-nerve growth factor signaling pathway1281417
GO:0042490IEA-mechanoreceptor differentiation-
GO:0042493IEA-response to drug-
GO:0043068ISS-positive regulation of programmed cell death-
GO:0043524ISS-negative regulation of neuron apoptotic process-
GO:0043547IDA-positive regulation of GTPase activity15488758
GO:0045471IEA-response to ethanol-
GO:0046579IDA-positive regulation of Ras protein signal transduction15488758
GO:0046777IDA-protein autophosphorylation15488758
GO:0048011IDA-neurotrophin TRK receptor signaling pathway15488758
GO:0048011TAS-neurotrophin TRK receptor signaling pathway-
GO:0048013IEA-ephrin receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048485ISS-sympathetic nervous system development-
GO:0048678IEA-response to axon injury-
GO:0050965IEA-detection of temperature stimulus involved in sensory perception of pain-
GO:0050966IEA-detection of mechanical stimulus involved in sensory perception of pain-
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity15488758
GO:0051599IEA-response to hydrostatic pressure-
GO:0051602IEA-response to electrical stimulus-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0051968IEA-positive regulation of synaptic transmission, glutamatergic-
GO:0060009IEA-Sertoli cell development-
GO:0060385ISS-axonogenesis involved in innervation-
GO:0061368IEA-behavioral response to formalin induced pain-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade15488758
GO:0071316IEA-cellular response to nicotine-
GO:1990090IMP-cellular response to nerve growth factor stimulus1281417
GO:1990090ISS-cellular response to nerve growth factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NTRK1ABL111096910679771 10708759 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NTRK1ABL110654310679771 10708759 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NTRK1CAV11073059867838 Affinity Capture-Western
NTRK1CAV11109699867838 Affinity Capture-Western
NTRK1GRB210914210748052 11733534 Affinity Capture-Western; Reconstituted Complex
NTRK1GRB211096910748052 11733534 Affinity Capture-Western; Reconstituted Complex
NTRK1MATK11096910329710 Affinity Capture-Western; Far Western
NTRK1MATK11031510329710 Affinity Capture-Western; Far Western
NTRK1NEDD411096916701206 Affinity Capture-Western; Biochemical Activity
NTRK1NEDD411081116701206 Affinity Capture-Western; Biochemical Activity
NTRK1NGF11096910490030 11729324 14985763 Co-crystal Structure; Reconstituted Complex
NTRK1NGF11086910490030 11729324 14985763 Co-crystal Structure; Reconstituted Complex
NTRK1NTF31109638621424 Reconstituted Complex
NTRK1NTF31109698621424 Reconstituted Complex
PLCG1NTRK11109691715690 9856458 10092678 10708759 Reconstituted Complex; Two-hybrid
PLCG1NTRK11113511715690 9856458 10092678 10708759 Reconstituted Complex; Two-hybrid
SHC1NTRK11109698183561 9856458 10092678 10708759 12446789 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHC1NTRK11123618183561 9856458 10092678 10708759 12446789 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHC3NTRK11109699507002 Affinity Capture-Western
SHC3NTRK11197529507002 Affinity Capture-Western
SH2B2NTRK11109699856458 Affinity Capture-Western; Two-hybrid
SH2B2NTRK11158509856458 Affinity Capture-Western; Two-hybrid
SH2B1NTRK11109699856458 10708759 Affinity Capture-Western; Two-hybrid
SH2B1NTRK11174559856458 10708759 Affinity Capture-Western; Two-hybrid
FRS2NTRK111096910092678 Reconstituted Complex; Two-hybrid
FRS2NTRK111603110092678 Reconstituted Complex; Two-hybrid
NTRK1NTRK111096910388563 Co-crystal Structure
SQSTM1NTRK111439711244088 12471037 18174161 18457658 Affinity Capture-Western
SQSTM1NTRK111096911244088 12471037 18174161 18457658 Affinity Capture-Western
RGS19NTRK111096911251075 Affinity Capture-Western
RGS19NTRK111557611251075 Affinity Capture-Western
GIPC1NTRK111597811251075 Affinity Capture-Western
GIPC1NTRK111096911251075 Affinity Capture-Western
RAP1ANTRK111096911466412 Affinity Capture-Western
RAP1ANTRK111184111466412 Affinity Capture-Western
PTPN1NTRK111096912237455 Protein-peptide
PTPN1NTRK111173612237455 Protein-peptide
ARHGAP32NTRK111096912446789 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARHGAP32NTRK111509112446789 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBCNTRK111096916701206 Affinity Capture-Western
UBCNTRK111316416701206 Affinity Capture-Western
TRAF6NTRK111304118457658 Affinity Capture-Western
TRAF6NTRK111096918457658 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NTRK1rs1799770, rs1800878, rs3753213, rs6334, rs6336, rs6339 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:97383
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-118'