AutismKB 2.0

Annotation Details for NTRK2


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Basic Information Top
Gene Symbol:NTRK2 ( GP145-TrkB,TRKB )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 2
Band: 9q21.33
Quick LinksEntrez ID:4915; OMIM: 600456; Uniprot ID:NTRK2_HUMAN; ENSEMBL ID: ENSG00000148053; HGNC ID: 8032
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005769ISS-early endosome-
GO:0005829IEA-cytosol-
GO:0005887IDA-integral component of plasma membrane15494731
GO:0014069IEA-postsynaptic density-
GO:0031901IEA-early endosome membrane-
GO:0043195IEA-terminal bouton-
GO:0043235IDA-receptor complex23382219
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005524IEA-ATP binding-
GO:0042803ISS-protein homodimerization activity-
GO:0043121IDA-neurotrophin binding11738045
GO:0043121ISS-neurotrophin binding-
GO:0048403ISS-brain-derived neurotrophic factor binding-
GO:0060175IMP-brain-derived neurotrophic factor-activated receptor activity15494731
GO ID Evidence Qualifier GO_term References
GO:0001570IEA-vasculogenesis-
GO:0001764ISS-neuron migration-
GO:0001934TAS-positive regulation of protein phosphorylation19036963
GO:0007528IEA-neuromuscular junction development-
GO:0007612ISS-learning-
GO:0007623IEA-circadian rhythm-
GO:0007631IEA-feeding behavior-
GO:0008284ISS-positive regulation of cell proliferation-
GO:0010628ISS-positive regulation of gene expression-
GO:0010976ISS-positive regulation of neuron projection development-
GO:0014047IEA-glutamate secretion-
GO:0014068ISS-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0021954ISS-central nervous system neuron development-
GO:0021987ISS-cerebral cortex development-
GO:0030182ISS-neuron differentiation-
GO:0031547IMP-brain-derived neurotrophic factor receptor signaling pathway15494731
GO:0031547TAS-brain-derived neurotrophic factor receptor signaling pathway19036963
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0038179IEA-neurotrophin signaling pathway-
GO:0042490IEA-mechanoreceptor differentiation-
GO:0043087ISS-regulation of GTPase activity-
GO:0043410ISS-positive regulation of MAPK cascade-
GO:0043524ISS-negative regulation of neuron apoptotic process-
GO:0046548IEA-retinal rod cell development-
GO:0046777ISS-protein autophosphorylation-
GO:0048709IEA-oligodendrocyte differentiation-
GO:0048935IEA-peripheral nervous system neuron development-
GO:0050772ISS-positive regulation of axonogenesis-
GO:0051896IEA-regulation of protein kinase B signaling-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0060041IEA-retina development in camera-type eye-
GO:0060291IEA-long-term synaptic potentiation-
GO:0071230IEA-cellular response to amino acid stimulus-
GO:0099551IEA-trans-synaptic signaling by neuropeptide, modulating synaptic transmission-
GO:2000811IEA-negative regulation of anoikis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NTRK2BDNF1109709312147 11855816 Reconstituted Complex
NTRK2BDNF1070969312147 11855816 Reconstituted Complex
NTRK2FYN1088109648856 Affinity Capture-Western; Reconstituted Complex
NTRK2FYN1109709648856 Affinity Capture-Western; Reconstituted Complex
NTRK2NTF31109638621424 Reconstituted Complex
NTRK2NTF31109708621424 Reconstituted Complex
NTRK2NTF411096411855816 Reconstituted Complex
NTRK2NTF411097011855816 Reconstituted Complex
SHC3NTRK21197529507002 12074588 Affinity Capture-Western; Two-hybrid
SHC3NTRK21109709507002 12074588 Affinity Capture-Western; Two-hybrid
FRS2NTRK211097010092678 Reconstituted Complex
FRS2NTRK211603110092678 Reconstituted Complex
SHC1NTRK211097010092678 Reconstituted Complex
SHC1NTRK211236110092678 Reconstituted Complex
PLCG1NTRK211097010092678 12074588 Reconstituted Complex; Two-hybrid
PLCG1NTRK211135110092678 12074588 Reconstituted Complex; Two-hybrid
DYNLL1NTRK211420611157096 Affinity Capture-Western
DYNLL1NTRK211097011157096 Affinity Capture-Western
GIPC1NTRK211597811251075 Affinity Capture-Western
GIPC1NTRK211097011251075 Affinity Capture-Western
NCK2NTRK211402012074588 Reconstituted Complex; Two-hybrid
NCK2NTRK211097012074588 Reconstituted Complex; Two-hybrid
SH2B1NTRK211097012074588 Two-hybrid
SH2B1NTRK211745512074588 Two-hybrid
PIK3R1NTRK211097012074588 Two-hybrid
PIK3R1NTRK211131312074588 Two-hybrid
PTPN1NTRK211097012237455 Protein-peptide
PTPN1NTRK211173612237455 Protein-peptide
SQSTM1NTRK211439712471037 18457658 Affinity Capture-Western
SQSTM1NTRK211097012471037 18457658 Affinity Capture-Western
UBCNTRK211316416701206 18457658 Affinity Capture-Western
UBCNTRK211097016701206 18457658 Affinity Capture-Western
TRAF6NTRK211304118457658 Affinity Capture-Western
TRAF6NTRK211097018457658 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
NTRK2rs1047856, rs10512159, rs11795386, rs1187326, rs1187327, rs12001219, rs1212171, rs1443445, rs1624327, rs17418241, rs1778931, rs2289656, rs3780645, rs4142909, rs4412435, rs4578034, rs6559840, rs7048278, rs893584 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
NTRK2rs10780691, rs1078947, rs1147198, rs1187341, rs1490403, rs1490404, rs1627784, rs2489162, rs3780632, rs7027979, rs920776, rs993315 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97384
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010126-1'