AutismKB 2.0

Annotation Details for NTRK3


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Basic Information Top
Gene Symbol:NTRK3 ( TRKC,gp145(trkC) )
Gene Full Name: neurotrophic tyrosine kinase, receptor, type 3
Band: 15q25.3
Quick LinksEntrez ID:4916; OMIM: 191316; Uniprot ID:NTRK3_HUMAN; ENSEMBL ID: ENSG00000140538; HGNC ID: 8033
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IEA-cytoplasm-
GO:0005886TAS-plasma membrane-
GO:0005887IEA-integral component of plasma membrane-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0002039IPI-p53 binding23027130
GO:0005004IEA-GPI-linked ephrin receptor activity-
GO:0005030IDA-neurotrophin receptor activity23027130
GO:0005515IPI-protein binding21102451
GO:0005524IEA-ATP binding-
GO:0043121TAS-neurotrophin binding7806211
GO ID Evidence Qualifier GO_term References
GO:0000187IDA-activation of MAPK activity23027130
GO:0001764IEA-neuron migration-
GO:0001933IDA-negative regulation of protein phosphorylation23027130
GO:0001934TAS-positive regulation of protein phosphorylation19036963
GO:0007169IDA-transmembrane receptor protein tyrosine kinase signaling pathway23027130
GO:0007507IMP-heart development25196463
GO:0007623IEA-circadian rhythm-
GO:0008284IDA-positive regulation of cell proliferation23027130
GO:0010628IDA-positive regulation of gene expression23027130
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0019056IEA-modulation by virus of host transcription-
GO:0030335IDA-positive regulation of cell migration23027130
GO:0032148IDA-activation of protein kinase B activity23027130
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation23027130
GO:0038179IEA-neurotrophin signaling pathway-
GO:0042490IEA-mechanoreceptor differentiation-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0045471IEA-response to ethanol-
GO:0046777IEA-protein autophosphorylation-
GO:0048013IEA-ephrin receptor signaling pathway-
GO:0048665IEA-neuron fate specification-
GO:0048678IEA-response to axon injury-
GO:0048691IEA-positive regulation of axon extension involved in regeneration-
GO:0048712IEA-negative regulation of astrocyte differentiation-
GO:0050927IDA-positive regulation of positive chemotaxis23027130
GO:0051412IEA-response to corticosterone-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0060548IEA-negative regulation of cell death-
GO:0070306IEA-lens fiber cell differentiation-
GO:0071300IEA-cellular response to retinoic acid-
GO:0090102IEA-cochlea development-
GO:0090630IDA-activation of GTPase activity23027130
GO:2000251IDA-positive regulation of actin cytoskeleton reorganization23027130
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NTRK3NTF31109638621424 Reconstituted Complex
NTRK3NTF31109718621424 Reconstituted Complex
FRS2NTRK311097110092678 Reconstituted Complex
FRS2NTRK311603110092678 Reconstituted Complex
PLCG1NTRK311097110092678 Reconstituted Complex
PLCG1NTRK311135110092678 Reconstituted Complex
SHC1NTRK311097110092678 Reconstituted Complex
SHC1NTRK311236110092678 Reconstituted Complex
PTPN1NTRK311097112237455 Protein-peptide
PTPN1NTRK311173612237455 Protein-peptide
SQSTM1NTRK311439712471037 Affinity Capture-Western
SQSTM1NTRK311097112471037 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
NTRK3rs10163123, rs10468138, rs1105962, rs11073758, rs11073763, rs11629691, rs12594283, rs12594538, rs12595249, rs1346164, rs1529323, rs16941103, rs16941212, rs16941563, rs1948066, rs2059588, rs3784407, rs3784432, rs3825885, rs4887342, rs4887348, rs4887350, rs4887361, rs4887400, rs6496460, rs7168277, rs7174354, rs7176520, rs7179806, rs8030107, rs8035178, rs8035265, rs999905 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97385
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010126-3'