AutismKB 2.0

Annotation Details for DDR2


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Basic Information Top
Gene Symbol:DDR2 ( MIG20a,NTRKR3,TKT,TYRO10 )
Gene Full Name: discoidin domain receptor tyrosine kinase 2
Band: 1q23.3
Quick LinksEntrez ID:4921; OMIM: 191311; Uniprot ID:DDR2_HUMAN; ENSEMBL ID: ENSG00000162733; HGNC ID: 2731
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IEA-integral component of plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0015629IDA-actin cytoskeleton-
GO:0016324IEA-apical plasma membrane-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity20004161
GO:0005515IPI-protein binding17703188
GO:0005518IDA-collagen binding20004161
GO:0005524IEA-ATP binding-
GO:0038062IDA-protein tyrosine kinase collagen receptor activity9659899
GO ID Evidence Qualifier GO_term References
GO:0001503IEA-ossification-
GO:0003416ISS-endochondral bone growth-
GO:0007155TAS-cell adhesion9659899
GO:0007165TAS-signal transduction9659899
GO:0010715TAS-regulation of extracellular matrix disassembly16626936
GO:0010763ISS-positive regulation of fibroblast migration-
GO:0010763TAS-positive regulation of fibroblast migration16626936
GO:0018108IDA-peptidyl-tyrosine phosphorylation20004161
GO:0030198TAS-extracellular matrix organization-
GO:0030199ISS-collagen fibril organization-
GO:0030500IMP-regulation of bone mineralization20564243
GO:0031214ISS-biomineral tissue development-
GO:0035988ISS-chondrocyte proliferation-
GO:0035988TAS-chondrocyte proliferation16626936
GO:0038063IDA-collagen-activated tyrosine kinase receptor signaling pathway16186108
GO:0045669IMP-positive regulation of osteoblast differentiation20564243
GO:0045860IMP-positive regulation of protein kinase activity20564243
GO:0046777IDA-protein autophosphorylation16186108
GO:0048146ISS-positive regulation of fibroblast proliferation-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity20564243
GO:0090091ISS-positive regulation of extracellular matrix disassembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SRCDDR211097511884411 Affinity Capture-Western
SRCDDR211259211884411 Affinity Capture-Western
SHC1DDR211097511884411 Affinity Capture-Western; Two-hybrid
SHC1DDR211236111884411 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1345277
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060503-361'