AutismKB 2.0

Annotation Details for NUMA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NUMA1 ( NUMA )
Gene Full Name: nuclear mitotic apparatus protein 1
Band: 11q13.4
Quick LinksEntrez ID:4926; OMIM: 164009; Uniprot ID:NUMA1_HUMAN; ENSEMBL ID: ENSG00000137497; HGNC ID: 8059
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0000922IDA-spindle pole14718566
GO:0005634IDA-nucleus1541636
GO:0005654IDA-nucleoplasm10811826
GO:0005654TAS-nucleoplasm-
GO:0005694IEA-chromosome-
GO:0005813IDA-centrosome25657325
GO:0005819TAS-spindle7004645
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005876IDA-spindle microtubule1541636
GO:0005938IDA-cell cortex23783028
GO:0016363IDA-nuclear matrix7962183
GO:0019897IDA-extrinsic component of plasma membrane24371089
GO:0030425IEA-dendrite-
GO:0031616IDA-spindle pole centrosome10811826
GO:0035371IDA-microtubule plus-end26765568
GO:0036449IDA-microtubule minus-end26765568
GO:0043025IEA-neuronal cell body-
GO:0043234IMP-protein complex20109190
GO:0045177IEA-apical part of cell-
GO:0055028IDA-cortical microtubule26765568
GO:0061673IDA-mitotic spindle astral microtubule1541636
GO:0070062IDA-extracellular exosome18570454
GO:0072686IDA-mitotic spindle10811826
GO:0097427IDA-microtubule bundle11956313
GO:0097431IDA-mitotic spindle pole1541636
GO:0097431IMP-mitotic spindle pole17172455
GO:0099738IDA-cell cortex region21816348
GO:1905720IDA-cytoplasmic microtubule bundle12445386
GO:1990023IDA-mitotic spindle midzone10811826
GO ID Evidence Qualifier GO_term References
GO:0005198TAS-structural molecule activity1541630
GO:0005515IPI-protein binding11781568
GO:0008017IDA-microtubule binding11956313
GO:0008022IMP-protein C-terminus binding20109190
GO:0015631IDA-tubulin binding11956313
GO:0035091IDA-phosphatidylinositol binding24371089
GO:0051010IDA-microtubule plus-end binding26765568
GO:0051011IDA-microtubule minus-end binding26765568
GO:0070840IDA-dynein complex binding10811826
GO:0097718IMP-disordered domain specific binding20109190
GO ID Evidence Qualifier GO_term References
GO:0000132IDA-establishment of mitotic spindle orientation21816348
GO:0000132IMP-establishment of mitotic spindle orientation24996901
GO:0000132ISS-establishment of mitotic spindle orientation-
GO:0001578IMP-microtubule bundle formation12445386
GO:0006997TAS-nucleus organization1541630
GO:0030513ISS-positive regulation of BMP signaling pathway-
GO:0030953IDA-astral microtubule organization12445386
GO:0030953IMP-astral microtubule organization12445386
GO:0031116IMP-positive regulation of microtubule polymerization12445386
GO:0032388IMP-positive regulation of intracellular transport27462074
GO:0045618ISS-positive regulation of keratinocyte differentiation-
GO:0051301IEA-cell division-
GO:0051321IEA-meiotic cell cycle-
GO:0051798ISS-positive regulation of hair follicle development-
GO:0051984IMP-positive regulation of chromosome segregation24371089
GO:0055048IMP-anastral spindle assembly25657325
GO:0060236IDA-regulation of mitotic spindle organization26195665
GO:0060236IMP-regulation of mitotic spindle organization11956313
GO:0060487IEA-lung epithelial cell differentiation-
GO:0090235IMP-regulation of metaphase plate congression27462074
GO:1902365IDA-positive regulation of protein localization to spindle pole body16076287
GO:1902846IMP-positive regulation of mitotic spindle elongation23921553
GO:1904778IMP-positive regulation of protein localization to cell cortex22327364
GO:1905820IMP-positive regulation of chromosome separation23921553
GO:1905832IMP-positive regulation of spindle assembly27462074
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NUMA1EPB4110834910189366 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMA1EPB4111098010189366 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMA1EPB41L110835010594058 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMA1EPB41L111098010594058 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUMA1EPB41L210835112239178 Reconstituted Complex
NUMA1EPB41L211098012239178 Reconstituted Complex
NUMA1NPM111098014968112 Affinity Capture-MS
NUMA1NPM111092914968112 Affinity Capture-MS
ACTR1ANUMA111098010504299 Affinity Capture-Western
ACTR1ANUMA111542510504299 Affinity Capture-Western
YEATS4NUMA111376110913114 11521196 Reconstituted Complex; Two-hybrid
YEATS4NUMA111098010913114 11521196 Reconstituted Complex; Two-hybrid
SMC1ANUMA111098011590136 Affinity Capture-Western
SMC1ANUMA111387111590136 Affinity Capture-Western
SMC3NUMA111457411590136 Affinity Capture-Western
SMC3NUMA111098011590136 Affinity Capture-Western
GPSM2NUMA111098011781568 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GPSM2NUMA111894911781568 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNKSNUMA111420712080061 Reconstituted Complex
TNKSNUMA111098012080061 Reconstituted Complex
PIM1NUMA111098012111331 Affinity Capture-Western; Biochemical Activity
PIM1NUMA111131012111331 Affinity Capture-Western; Biochemical Activity
NCOA6NUMA111669112519782 Affinity Capture-MS
NCOA6NUMA111098012519782 Affinity Capture-MS
RPAP1NUMA111098017643375 Affinity Capture-MS
RPAP1NUMA111748717643375 Affinity Capture-MS
SUMO2NUMA111249719394292 Affinity Capture-MS
SUMO2NUMA111098019394292 Affinity Capture-MS
BANF1NUMA111098019759913 Affinity Capture-MS
BANF1NUMA111434219759913 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2443665
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved