Gene Symbol:	NR4A2 ( HZF-3,NOT,NURR1,RNR1,TINUR )
Gene Full Name:	nuclear receptor subfamily 4, group A, member 2
Band:	2q22-q23
Quick Links	Entrez ID:4929; OMIM: 601828; Uniprot ID:NR4A2_HUMAN; ENSEMBL ID: ENSG00000153234; HGNC ID: 7981
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	17184956
GO:0005634	TAS	-	nucleus	16243425
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IEA	-	cytoplasm	-
GO:0016607	IDA	-	nuclear speck	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000979	IEA	-	RNA polymerase II core promoter sequence-specific DNA binding	-
GO:0001077	ISS	-	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	-
GO:0003677	TAS	-	DNA binding	16243425
GO:0003707	IEA	-	steroid hormone receptor activity	-
GO:0004879	TAS	-	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	16243425
GO:0005515	IPI	-	protein binding	20195357
GO:0008013	TAS	-	beta-catenin binding	22988876
GO:0008270	IEA	-	zinc ion binding	-
GO:0035259	IEA	-	glucocorticoid receptor binding	-
GO:0042803	TAS	-	protein homodimerization activity	16243425
GO:0046965	TAS	-	retinoid X receptor binding	16243425
GO:0046982	ISS	-	protein heterodimerization activity	-
GO:0046982	TAS	-	protein heterodimerization activity	16243425

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IMP	-	negative regulation of transcription from RNA polymerase II promoter	18463503
GO:0000122	TAS	-	negative regulation of transcription from RNA polymerase II promoter	22988876
GO:0001666	IEA	-	response to hypoxia	-
GO:0001764	TAS	-	neuron migration	16243425
GO:0001975	IEA	-	response to amphetamine	-
GO:0006351	IDA	-	transcription, DNA-templated	17184956
GO:0006367	TAS	-	transcription initiation from RNA polymerase II promoter	-
GO:0007165	NAS	-	signal transduction	7877627
GO:0008344	IEA	-	adult locomotory behavior	-
GO:0009791	IEA	-	post-embryonic development	-
GO:0021952	IEA	-	central nervous system projection neuron axonogenesis	-
GO:0021986	IEA	-	habenula development	-
GO:0030522	IEA	-	intracellular receptor signaling pathway	-
GO:0031668	IDA	-	cellular response to extracellular stimulus	7877627
GO:0034599	IEA	-	cellular response to oxidative stress	-
GO:0042053	IEA	-	regulation of dopamine metabolic process	-
GO:0042416	IEA	-	dopamine biosynthetic process	-
GO:0042551	IEA	-	neuron maturation	-
GO:0043085	IEA	-	positive regulation of catalytic activity	-
GO:0043401	IEA	-	steroid hormone mediated signaling pathway	-
GO:0043524	IEA	-	negative regulation of neuron apoptotic process	-
GO:0043576	IEA	-	regulation of respiratory gaseous exchange	-
GO:0045444	ISS	-	fat cell differentiation	-
GO:0045944	ISS	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0045944	TAS	-	positive regulation of transcription from RNA polymerase II promoter	24115276
GO:0051866	IEA	-	general adaptation syndrome	-
GO:0060070	TAS	-	canonical Wnt signaling pathway	24115276
GO:0071376	ISS	-	cellular response to corticotropin-releasing hormone stimulus	-
GO:0071542	ISS	-	dopaminergic neuron differentiation	-
GO:1904948	TAS	-	midbrain dopaminergic neuron differentiation	16243425
GO:2001234	IMP	-	negative regulation of apoptotic signaling pathway	19429166

Gene Symbol	Interactant	Interaction ID	References	Description
NR4A2	RUNX1	110983	21468021	Affinity Capture-Western
NR4A2	RUNX1	107309	21468021	Affinity Capture-Western
RARA	NR4A2	111849	7705655	Reconstituted Complex; Two-hybrid
RARA	NR4A2	110983	7705655	Reconstituted Complex; Two-hybrid
RARB	NR4A2	110983	7705655	Reconstituted Complex; Two-hybrid
RARB	NR4A2	111850	7705655	Reconstituted Complex; Two-hybrid
SMARCA2	NR4A2	110983	17043312	Affinity Capture-Western; Reconstituted Complex
SMARCA2	NR4A2	112479	17043312	Affinity Capture-Western; Reconstituted Complex
SMARCA4	NR4A2	112481	17043312	Affinity Capture-Western; Reconstituted Complex
SMARCA4	NR4A2	110983	17043312	Affinity Capture-Western; Reconstituted Complex
SIN3A	NR4A2	110983	19144721	Affinity Capture-Western
SIN3A	NR4A2	117439	19144721	Affinity Capture-Western
SFPQ	NR4A2	110983	19144721	Affinity Capture-Western
SFPQ	NR4A2	112319	19144721	Affinity Capture-Western
NCOR2	NR4A2	110983	19144721	Affinity Capture-Western
NCOR2	NR4A2	114974	19144721	Affinity Capture-Western

AutismKB 2.0

Annotation Details for NR4A2