AutismKB 2.0

Annotation Details for ATP2B4


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Basic Information Top
Gene Symbol:ATP2B4 ( ATP2B2,DKFZp686G08106,DKFZp686M088,MXRA1,PMCA4,PMCA4b,PMCA4x )
Gene Full Name: ATPase, Ca++ transporting, plasma membrane 4
Band: 1q32.1
Quick LinksEntrez ID:493; OMIM: 108732; Uniprot ID:AT2B4_HUMAN; ENSEMBL ID: ENSG00000058668; HGNC ID: 817
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane2137451
GO:0005901TAS-caveola11591728
GO:0016020IDA-membrane8530416
GO:0016323IEA-basolateral plasma membrane-
GO:0030018IDA-Z disc19287093
GO:0030315IDA-T-tubule19287093
GO:0036126ISS-sperm flagellum-
GO:0043005IEA-neuron projection-
GO:0043231IBA-intracellular membrane-bounded organelle-
GO:0043234ISS-protein complex-
GO:0097228IEA-sperm principal piece-
GO ID Evidence Qualifier GO_term References
GO:0005388IMP-calcium-transporting ATPase activity8530416
GO:0005388TAS-calcium-transporting ATPase activity-
GO:0005515IPI-protein binding17242280
GO:0005516IDA-calmodulin binding8530416
GO:0005524IEA-ATP binding-
GO:0017080ISScontributes_tosodium channel regulator activity-
GO:0019901IEA-protein kinase binding-
GO:0030165IBA-PDZ domain binding-
GO:0030346IDA-protein phosphatase 2B binding19287093
GO:0036487IDA-nitric-oxide synthase inhibitor activity17242280
GO:0036487IDAcontributes_tonitric-oxide synthase inhibitor activity11591728
GO:0046872IEA-metal ion binding-
GO:0050998IPI-nitric-oxide synthase binding11591728
GO:0097110ISS-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0003407IEA-neural retina development-
GO:0006357IMP-regulation of transcription from RNA polymerase II promoter19287093
GO:0006874IC-cellular calcium ion homeostasis8530416
GO:0006874IDA-cellular calcium ion homeostasis19278978
GO:0006874ISS-cellular calcium ion homeostasis-
GO:0007283IEA-spermatogenesis-
GO:0010751IDA-negative regulation of nitric oxide mediated signal transduction19278978
GO:0021766IEA-hippocampus development-
GO:0030317ISS-flagellated sperm motility-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19278978
GO:0034220TAS-ion transmembrane transport-
GO:0045019IDA-negative regulation of nitric oxide biosynthetic process11591728
GO:0051001IDA-negative regulation of nitric-oxide synthase activity11591728
GO:0051599IMP-response to hydrostatic pressure19287093
GO:0070588IMP-calcium ion transmembrane transport8530416
GO:0070885IDA-negative regulation of calcineurin-NFAT signaling cascade19287093
GO:0071872IDA-cellular response to epinephrine stimulus19278978
GO:0097553IC-calcium ion transmembrane import into cytosol8530416
GO:0098703IC-calcium ion import across plasma membrane8530416
GO:0098736IDA-negative regulation of the force of heart contraction17242280
GO:0099132IEA-ATP hydrolysis coupled cation transmembrane transport-
GO:1900082IDA-negative regulation of arginine catabolic process19278978
GO:1901205IDA-negative regulation of adrenergic receptor signaling pathway involved in heart process17242280
GO:1901660IEA-calcium ion export-
GO:1902083NAS-negative regulation of peptidyl-cysteine S-nitrosylation18591664
GO:1902305IC-regulation of sodium ion transmembrane transport18591664
GO:1902806IMP-regulation of cell cycle G1/S phase transition24448801
GO:1903243IMP-negative regulation of cardiac muscle hypertrophy in response to stress19287093
GO:1903249IDA-negative regulation of citrulline biosynthetic process19278978
GO:1903779TAS-regulation of cardiac conduction-
GO:2000481IDA-positive regulation of cAMP-dependent protein kinase activity19278978
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DLG2ATP2B410808411274188 Affinity Capture-Western
DLG2ATP2B410698311274188 Affinity Capture-Western
DLG3ATP2B410808511274188 Affinity Capture-Western
DLG3ATP2B410698311274188 Affinity Capture-Western
CASKATP2B410698312511555 Co-fractionation; Reconstituted Complex
CASKATP2B411414112511555 Co-fractionation; Reconstituted Complex
DLG1ATP2B410808312511555 Reconstituted Complex
DLG1ATP2B410698312511555 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88111
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061027-60'