AutismKB 2.0

Annotation Details for OAS1


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Basic Information Top
Gene Symbol:OAS1 ( IFI-4,OIAS,OIASI )
Gene Full Name: 2',5'-oligoadenylate synthetase 1, 40/46kDa
Band: 12q24.2
Quick LinksEntrez ID:4938; OMIM: 164350; Uniprot ID:OAS1_HUMAN; ENSEMBL ID: ENSG00000089127; HGNC ID: 8086
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005634IEA-nucleus-
GO:0005739IEA-mitochondrion-
GO:0005783IEA-endoplasmic reticulum-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0001730IDA-2'-5'-oligoadenylate synthetase activity12799444
GO:0003725IDA-double-stranded RNA binding12799444
GO:0005515IPI-protein binding15039538
GO:0005524TAS-ATP binding21142819
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006006IMP-glucose metabolic process23575436
GO:0009615IDA-response to virus18931074
GO:0042593IMP-glucose homeostasis23575436
GO:0045071IDA-negative regulation of viral genome replication18931074
GO:0051607IEA-defense response to virus-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060337TAS-type I interferon signaling pathway-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97429
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018