AutismKB 2.0

Annotation Details for OPRM1


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Basic Information Top
Gene Symbol:OPRM1 ( KIAA0403,LMOR,MOR,MOR1,OPRM )
Gene Full Name: opioid receptor, mu 1
Band: 6q25.2
Quick LinksEntrez ID:4988; OMIM: 600018; Uniprot ID:OPRM_HUMAN; ENSEMBL ID: ENSG00000112038; HGNC ID: 8156
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005768ISS-endosome-
GO:0005783TAS-endoplasmic reticulum9242668
GO:0005794TAS-Golgi apparatus9242668
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane7905839
GO:0005925IEA-focal adhesion-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0032590IEA-dendrite membrane-
GO:0032839IEA-dendrite cytoplasm-
GO:0042383IEA-sarcolemma-
GO:0043005IBA-neuron projection-
GO:0043204IEA-perikaryon-
GO:0045121IEA-membrane raft-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0001965IDA-G-protein alpha-subunit binding20214800
GO:0004930ISS-G-protein coupled receptor activity-
GO:0004979IMP-beta-endorphin receptor activity9689128
GO:0005245ISS-voltage-gated calcium channel activity-
GO:0005515IPI-protein binding14573758
GO:0008022IEA-protein C-terminus binding-
GO:0019904IEA-protein domain specific binding-
GO:0031005IEA-filamin binding-
GO:0031681IBA-G-protein beta-subunit binding-
GO:0038047IBA-morphine receptor activity-
GO:0038047ISS-morphine receptor activity-
GO:0042923IBA-neuropeptide binding-
GO ID Evidence Qualifier GO_term References
GO:0002438IEA-acute inflammatory response to antigenic stimulus-
GO:0007187TAS-G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger7905839
GO:0007191IEA-adenylate cyclase-activating dopamine receptor signaling pathway-
GO:0007194ISS-negative regulation of adenylate cyclase activity-
GO:0007200ISS-phospholipase C-activating G-protein coupled receptor signaling pathway-
GO:0007218IEA-neuropeptide signaling pathway-
GO:0007268IBA-chemical synaptic transmission-
GO:0007600NAS-sensory perception9689128
GO:0007626IEA-locomotory behavior-
GO:0008285TAS-negative regulation of cell proliferation2159143
GO:0009314IEA-response to radiation-
GO:0019233IBA-sensory perception of pain-
GO:0019233ISS-sensory perception of pain-
GO:0031635IEA-adenylate cyclase-inhibiting opioid receptor signaling pathway-
GO:0032094IEA-response to food-
GO:0032100IEA-positive regulation of appetite-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033554IMP-cellular response to stress21039637
GO:0038003ISS-opioid receptor signaling pathway-
GO:0042060IEA-wound healing-
GO:0042220IEA-response to cocaine-
GO:0042755IEA-eating behavior-
GO:0044849IEA-estrous cycle-
GO:0048149IMP-behavioral response to ethanol21039637
GO:0050769ISS-positive regulation of neurogenesis-
GO:0051930IEA-regulation of sensory perception of pain-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0061358IMP-negative regulation of Wnt protein secretion20214800
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0070588IEA-calcium ion transmembrane transport-
GO:0070848IEA-response to growth factor-
GO:0071315IBA-cellular response to morphine-
GO:2000310ISS-regulation of NMDA receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
OPRM1ARF111103312519790 Affinity Capture-Western
OPRM1ARF110687012519790 Affinity Capture-Western
OPRM1CALM110725211457836 Reconstituted Complex
OPRM1CALM111103311457836 Reconstituted Complex
OPRM1GNAO11090378393523 Affinity Capture-Western
OPRM1GNAO11110338393523 Affinity Capture-Western
OPRM1OPRD111103011069979 Affinity Capture-Western
OPRM1OPRD111103311069979 Affinity Capture-Western
PLD2OPRM111103312519790 Affinity Capture-Western
PLD2OPRM111135412519790 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
OPRM1rs1799971 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97441
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010125-1'