AutismKB 2.0

Annotation Details for OSM


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Basic Information Top
Gene Symbol:OSM ( MGC20461 )
Gene Full Name: oncostatin M
Band: 22q12.2
Quick LinksEntrez ID:5008; OMIM: 165095; Uniprot ID:ONCM_HUMAN; ENSEMBL ID: ENSG00000099985; HGNC ID: 8506
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0005622IEA-intracellular-
GO ID Evidence Qualifier GO_term References
GO:0005125IDA-cytokine activity8999038
GO:0005147IPI-oncostatin-M receptor binding8999038
GO:0008083IDA-growth factor activity8999038
GO ID Evidence Qualifier GO_term References
GO:0002675IC-positive regulation of acute inflammatory response8999038
GO:0006955IEA-immune response-
GO:0007260IEA-tyrosine phosphorylation of STAT protein-
GO:0007275TAS-multicellular organism development1717982
GO:0007422IEA-peripheral nervous system development-
GO:0008283TAS-cell proliferation1542793
GO:0008284IDA-positive regulation of cell proliferation8999038
GO:0008285TAS-negative regulation of cell proliferation1717982
GO:0009408IEA-response to heat-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation7508917
GO:0038165IDA-oncostatin-M-mediated signaling pathway8999038
GO:0040008IEA-regulation of growth-
GO:0042531IDA-positive regulation of tyrosine phosphorylation of STAT protein21912637
GO:0043410IDA-positive regulation of MAPK cascade7508917
GO:0045835IEA-negative regulation of meiotic nuclear division-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter7508917
GO:0046888IDA-negative regulation of hormone secretion7867561
GO:0048266IEA-behavioral response to pain-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation7508917
GO:0051781IEA-positive regulation of cell division-
GO:2001235IEA-positive regulation of apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
OSMLIFR1110491536831 Affinity Capture-Western
OSMLIFR1101651536831 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104749
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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