AutismKB 2.0

Annotation Details for OXT


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Basic Information Top
Gene Symbol:OXT ( MGC126890,MGC126892,OT,OT-NPI )
Gene Full Name: oxytocin, prepropeptide
Band: 20p13
Quick LinksEntrez ID:5020; OMIM: 167050; Uniprot ID:NEU1_HUMAN; ENSEMBL ID: ENSG00000101405; HGNC ID: 8528
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IEA-extracellular space-
GO:0030141IEA-secretory granule-
GO:0043195IEA-terminal bouton-
GO ID Evidence Qualifier GO_term References
GO:0005185IEA-neurohypophyseal hormone activity-
GO:0031855IEA-oxytocin receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0001975IEA-response to amphetamine-
GO:0002027IEA-regulation of heart rate-
GO:0002125IEA-maternal aggressive behavior-
GO:0007165TAS-signal transduction10218979
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0007507IEA-heart development-
GO:0007565IEA-female pregnancy-
GO:0007613IEA-memory-
GO:0007625IEA-grooming behavior-
GO:0009744IEA-response to sucrose-
GO:0010701IEA-positive regulation of norepinephrine secretion-
GO:0014823IEA-response to activity-
GO:0030431IEA-sleep-
GO:0032094IEA-response to food-
GO:0032308IEA-positive regulation of prostaglandin secretion-
GO:0032355IEA-response to estradiol-
GO:0032526IEA-response to retinoic acid-
GO:0032570IEA-response to progesterone-
GO:0034695IEA-response to prostaglandin E-
GO:0035176IEA-social behavior-
GO:0035811IEA-negative regulation of urine volume-
GO:0035815IEA-positive regulation of renal sodium excretion-
GO:0042220IEA-response to cocaine-
GO:0042538IEA-hyperosmotic salinity response-
GO:0042711IEA-maternal behavior-
GO:0042713IEA-sperm ejaculation-
GO:0042755IEA-eating behavior-
GO:0042756IEA-drinking behavior-
GO:0043434IEA-response to peptide hormone-
GO:0045472IEA-response to ether-
GO:0045776IEA-negative regulation of blood pressure-
GO:0045777IEA-positive regulation of blood pressure-
GO:0045778IEA-positive regulation of ossification-
GO:0045925IEA-positive regulation of female receptivity-
GO:0050806IEA-positive regulation of synaptic transmission-
GO:0051384IEA-response to glucocorticoid-
GO:0051591IEA-response to cAMP-
GO:0051602IEA-response to electrical stimulus-
GO:0051930IEA-regulation of sensory perception of pain-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0060179IEA-male mating behavior-
GO:0060406IEA-positive regulation of penile erection-
GO:0060450IEA-positive regulation of hindgut contraction-
GO:0060455IEA-negative regulation of gastric acid secretion-
GO:0070474IEA-positive regulation of uterine smooth muscle contraction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
OXTMLL11106014607844 Biochemical Activity
OXTMLL11044314607844 Biochemical Activity
TXNDC17OXT11106014607844 Biochemical Activity
TXNDC17OXT12427714607844 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
OXTrs2740204, rs2740210, rs2770378, rs3761248, rs4813625, rs877172 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97453
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018