AutismKB 2.0

Annotation Details for OXTR


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Basic Information Top
Gene Symbol:OXTR ( OT-R )
Gene Full Name: oxytocin receptor
Band: 3p25.3
Quick LinksEntrez ID:5021; OMIM: 167055; Uniprot ID:OXYR_HUMAN; ENSEMBL ID: ENSG00000180914; HGNC ID: 8529
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane10858434
GO:0005902IEA-microvillus-
GO:0005913IEA-cell-cell adherens junction-
GO:0016324IEA-apical plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004990IBA-oxytocin receptor activity-
GO:0005000IBA-vasopressin receptor activity-
GO:0017046IEA-peptide hormone binding-
GO:0042277IBA-peptide binding-
GO ID Evidence Qualifier GO_term References
GO:0001967IEA-suckling behavior-
GO:0001975IEA-response to amphetamine-
GO:0001992IBA-regulation of systemic arterial blood pressure by vasopressin-
GO:0006936TAS-muscle contraction1313946
GO:0007166TAS-cell surface receptor signaling pathway1313946
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0007507IEA-heart development-
GO:0007565IBA-female pregnancy-
GO:0007595TAS-lactation1313946
GO:0007613IEA-memory-
GO:0010701IEA-positive regulation of norepinephrine secretion-
GO:0021537IEA-telencephalon development-
GO:0030431IEA-sleep-
GO:0032230IEA-positive regulation of synaptic transmission, GABAergic-
GO:0032355IEA-response to estradiol-
GO:0032570IEA-response to progesterone-
GO:0032870IBA-cellular response to hormone stimulus-
GO:0034059IEA-response to anoxia-
GO:0034097IEA-response to cytokine-
GO:0035176IBA-social behavior-
GO:0042220IEA-response to cocaine-
GO:0042493IEA-response to drug-
GO:0042711IBA-maternal behavior-
GO:0042713IEA-sperm ejaculation-
GO:0042755IEA-eating behavior-
GO:0043434IEA-response to peptide hormone-
GO:0044849IEA-estrous cycle-
GO:0045777IEA-positive regulation of blood pressure-
GO:0045907IBA-positive regulation of vasoconstriction-
GO:0048565IEA-digestive tract development-
GO:0051965IEA-positive regulation of synapse assembly-
GO:0051968IEA-positive regulation of synaptic transmission, glutamatergic-
GO:0060137IEA-maternal process involved in parturition-
GO:0060406IEA-positive regulation of penile erection-
GO:0060455IEA-negative regulation of gastric acid secretion-
GO:0070371IEA-ERK1 and ERK2 cascade-
GO:0070474IEA-positive regulation of uterine smooth muscle contraction-
GO:1901652IBA-response to peptide-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
OXTRGRK511106110858434 Affinity Capture-Western
OXTRGRK510912710858434 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
OXTRrs1042778, rs11131149, rs11706648, rs2268492, rs2268496, rs237884, rs237885, rs237887, rs237894, rs237899, rs4686301, rs9840864 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109147
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018