AutismKB 2.0

Annotation Details for P2RX4


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Basic Information Top
Gene Symbol:P2RX4 ( P2X4,P2X4R )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 4
Band: 12q24.31
Quick LinksEntrez ID:5025; OMIM: 600846; Uniprot ID:P2RX4_HUMAN; ENSEMBL ID: ENSG00000135124; HGNC ID: 8535
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005639IBA-integral component of nuclear inner membrane-
GO:0005765IDA-lysosomal membrane17897319
GO:0005886ISS-plasma membrane17785580
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane11606481
GO:0005887IMP-integral component of plasma membrane10515189
GO:0014069IEA-postsynaptic density-
GO:0016020IDA-membrane17785580
GO:0030054IDA-cell junction12088286
GO:0043025IEA-neuronal cell body-
GO:0043195IEA-terminal bouton-
GO:0043197IEA-dendritic spine-
GO:0048471IDA-perinuclear region of cytoplasm12088286
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001614IDA-purinergic nucleotide receptor activity9016352
GO:0001614IMP-purinergic nucleotide receptor activity11606481
GO:0004931IDA-extracellular ATP-gated cation channel activity9016352
GO:0005102ISS-receptor binding17785580
GO:0005507ISS-copper ion binding12819199
GO:0005515IPI-protein binding25416956
GO:0005524IC-ATP binding11606481
GO:0008144IEA-drug binding-
GO:0008270ISS-zinc ion binding12819199
GO:0042803NAS-protein homodimerization activity17895406
GO:0045296IPI-cadherin binding12088286
GO ID Evidence Qualifier GO_term References
GO:0001894NAS-tissue homeostasis17264311
GO:0002028ISS-regulation of sodium ion transport17785580
GO:0006810IDA-transport9016352
GO:0007165IDA-signal transduction9016352
GO:0007596TAS-blood coagulation-
GO:0008217IMP-regulation of blood pressure11606481
GO:0010524IDA-positive regulation of calcium ion transport into cytosol10969036
GO:0010524IMP-positive regulation of calcium ion transport into cytosol10899068
GO:0010614IMP-negative regulation of cardiac muscle hypertrophy15130891
GO:0019228IEA-neuronal action potential-
GO:0019233ISS-sensory perception of pain14978347
GO:0032308NAS-positive regulation of prostaglandin secretion10899068
GO:0033198IDA-response to ATP9016352
GO:0034220IDA-ion transmembrane transport10515189
GO:0034405IDA-response to fluid shear stress10969036
GO:0035590IMP-purinergic nucleotide receptor signaling pathway11606481
GO:0042118TAS-endothelial cell activation12088286
GO:0043536IMP-positive regulation of blood vessel endothelial cell migration21106936
GO:0045429NAS-positive regulation of nitric oxide biosynthetic process10899068
GO:0050850IDA-positive regulation of calcium-mediated signaling10969036
GO:0050850IMP-positive regulation of calcium-mediated signaling10899068
GO:0051260IEA-protein homooligomerization-
GO:0051899IDA-membrane depolarization9016352
GO:0051928NAS-positive regulation of calcium ion transport15130891
GO:0055117IMP-regulation of cardiac muscle contraction11606481
GO:0055119IMP-relaxation of cardiac muscle11606481
GO:0060079IEA-excitatory postsynaptic potential-
GO:0071318IDA-cellular response to ATP10515189
GO:0097190IDA-apoptotic signaling pathway17264311
GO:0098655IEA-cation transmembrane transport-
GO:2001028IMP-positive regulation of endothelial cell chemotaxis21106936
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
P2RX4CDH511106412088286 Affinity Capture-Western
P2RX4CDH510743812088286 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338859
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020806-2'