AutismKB 2.0

Annotation Details for P2RX7


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Basic Information Top
Gene Symbol:P2RX7 ( MGC20089,P2X7 )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 7
Band: 12q24.31
Quick LinksEntrez ID:5027; OMIM: 602566; Uniprot ID:A8K2Z0_HUMAN; ENSEMBL ID: ENSG00000089041; HGNC ID: 8537
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005639IBA-integral component of nuclear inner membrane-
GO:0005737ISS-cytoplasm-
GO:0005886IDA-plasma membrane12107182
GO:0005886ISS-plasma membrane17785580
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane9038151
GO:0005911IEA-cell-cell junction-
GO:0009897IEA-external side of plasma membrane-
GO:0016020IDA-membrane17785580
GO:0031594IEA-neuromuscular junction-
GO:0032059ISS-bleb-
GO:0043025IEA-neuronal cell body-
GO:0098793IEA-presynapse-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0001530ISS-lipopolysaccharide binding-
GO:0001614IDA-purinergic nucleotide receptor activity9038151
GO:0004931IDA-extracellular ATP-gated cation channel activity9038151
GO:0004931TAS-extracellular ATP-gated cation channel activity-
GO:0005102ISS-receptor binding17785580
GO:0005515IPI-protein binding12107182
GO:0005524IC-ATP binding9038151
GO:0042803NAS-protein homodimerization activity17895406
GO ID Evidence Qualifier GO_term References
GO:0000187IEA-activation of MAPK activity-
GO:0000902IEA-cell morphogenesis-
GO:0001845IEA-phagolysosome assembly-
GO:0001916IEA-positive regulation of T cell mediated cytotoxicity-
GO:0002028ISS-regulation of sodium ion transport17785580
GO:0006468IEA-protein phosphorylation-
GO:0006509IEA-membrane protein ectodomain proteolysis-
GO:0006649IEA-phospholipid transfer to membrane-
GO:0006900IEA-membrane budding-
GO:0006954IEA-inflammatory response-
GO:0007005IEA-mitochondrion organization-
GO:0007166ISS-cell surface receptor signaling pathway-
GO:0007596TAS-blood coagulation-
GO:0009612IEA-response to mechanical stimulus-
GO:0010043IEA-response to zinc ion-
GO:0010524IDA-positive regulation of calcium ion transport into cytosol9038151
GO:0010628IMP-positive regulation of gene expression22898868
GO:0014049IEA-positive regulation of glutamate secretion-
GO:0014054IEA-positive regulation of gamma-aminobutyric acid secretion-
GO:0016079IEA-synaptic vesicle exocytosis-
GO:0016485IEA-protein processing-
GO:0017121IDA-phospholipid scrambling25651887
GO:0019233ISS-sensory perception of pain-
GO:0019835IEA-cytolysis-
GO:0030501ISS-positive regulation of bone mineralization-
GO:0031668IEA-cellular response to extracellular stimulus-
GO:0032060IDA-bleb assembly12107182
GO:0032060ISS-bleb assembly-
GO:0032308IEA-positive regulation of prostaglandin secretion-
GO:0032496IEA-response to lipopolysaccharide-
GO:0032755IEA-positive regulation of interleukin-6 production-
GO:0032963IEA-collagen metabolic process-
GO:0033198IDA-response to ATP9038151
GO:0034405IEA-response to fluid shear stress-
GO:0034767IMP-positive regulation of ion transmembrane transport25651887
GO:0035590IMP-purinergic nucleotide receptor signaling pathway25651887
GO:0042098IEA-T cell proliferation-
GO:0042493IEA-response to drug-
GO:0043029IEA-T cell homeostasis-
GO:0043132IEA-NAD transport-
GO:0043409ISS-negative regulation of MAPK cascade-
GO:0044254IEA-multicellular organismal protein catabolic process-
GO:0045332IEA-phospholipid translocation-
GO:0045779ISS-negative regulation of bone resorption-
GO:0045794IMP-negative regulation of cell volume25651887
GO:0045821IMP-positive regulation of glycolytic process22898868
GO:0045919ISS-positive regulation of cytolysis-
GO:0046513IEA-ceramide biosynthetic process-
GO:0046931IDA-pore complex assembly9038151
GO:0046931IMP-pore complex assembly25651887
GO:0048705IEA-skeletal system morphogenesis-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0050717IEA-positive regulation of interleukin-1 alpha secretion-
GO:0050718IDA-positive regulation of interleukin-1 beta secretion17036048
GO:0050830IEA-defense response to Gram-positive bacterium-
GO:0051209IEA-release of sequestered calcium ion into cytosol-
GO:0051259IEA-protein oligomerization-
GO:0051495ISS-positive regulation of cytoskeleton organization-
GO:0051592IEA-response to calcium ion-
GO:0051602IEA-response to electrical stimulus-
GO:0051709NAS-regulation of killing of cells of other organism17785580
GO:0051899IDA-membrane depolarization9038151
GO:0051901IEA-positive regulation of mitochondrial depolarization-
GO:0060079IEA-excitatory postsynaptic potential-
GO:0070230IEA-positive regulation of lymphocyte apoptotic process-
GO:0071359IEA-cellular response to dsRNA-
GO:0072593IEA-reactive oxygen species metabolic process-
GO:0097190ISS-apoptotic signaling pathway-
GO:0097191IEA-extrinsic apoptotic signaling pathway-
GO:1904172IMP-positive regulation of bleb assembly25651887
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
P2RX7rs1653624, rs1718119, rs208294, rs2230911, rs2230912, rs28360447, rs28360457, rs35933842, rs3751143 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1339957
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030319-6'