AutismKB 2.0

Annotation Details for P2RY1


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Basic Information Top
Gene Symbol:P2RY1 ( P2Y1 )
Gene Full Name: purinergic receptor P2Y, G-protein coupled, 1
Band: 3q25.2
Quick LinksEntrez ID:5028; OMIM: 601167; Uniprot ID:P2RY1_HUMAN; ENSEMBL ID: ENSG00000169860; HGNC ID: 8539
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IEA-mitochondrion-
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane8630005
GO:0009986IDA-cell surface23382103
GO:0014069ISS-postsynaptic density-
GO:0016323IEA-basolateral plasma membrane-
GO:0016324IEA-apical plasma membrane-
GO:0030425ISS-dendrite-
GO:0044297ISS-cell body-
GO:0045211ISS-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity8630005
GO:0005515IPI-protein binding9671706
GO:0005524IEA-ATP binding-
GO:0031686IEA-A1 adenosine receptor binding-
GO:0043531IEA-ADP binding-
GO:0045028ISS-G-protein coupled purinergic nucleotide receptor activity-
GO:0045031ISS-ATP-activated adenosine receptor activity-
GO:0045032IEA-ADP-activated adenosine receptor activity-
GO:0046982IEA-protein heterodimerization activity-
GO:0097110ISS-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001934ISS-positive regulation of protein phosphorylation-
GO:0001973IEA-adenosine receptor signaling pathway-
GO:0007166TAS-cell surface receptor signaling pathway8630005
GO:0007186ISS-G-protein coupled receptor signaling pathway-
GO:0007193IEA-adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-
GO:0007200IEA-phospholipase C-activating G-protein coupled receptor signaling pathway-
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0007568IEA-aging-
GO:0008347IEA-glial cell migration-
GO:0009612IEA-response to mechanical stimulus-
GO:0010469IEA-regulation of receptor activity-
GO:0010700IEA-negative regulation of norepinephrine secretion-
GO:0019233IEA-sensory perception of pain-
GO:0023019ISS-signal transduction involved in regulation of gene expression-
GO:0030168IEA-platelet activation-
GO:0032962IEA-positive regulation of inositol trisphosphate biosynthetic process-
GO:0035589IEA-G-protein coupled purinergic nucleotide receptor signaling pathway-
GO:0042755IEA-eating behavior-
GO:0043270IEA-positive regulation of ion transport-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046887IEA-positive regulation of hormone secretion-
GO:0051100IEA-negative regulation of binding-
GO:0060406IEA-positive regulation of penile erection-
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0070848IEA-response to growth factor-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0072659ISS-protein localization to plasma membrane-
GO:0090075IEA-relaxation of muscle-
GO:0097746IEA-regulation of blood vessel diameter-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
P2RY1ADORA111106711390975 Affinity Capture-Western
P2RY1ADORA110664611390975 Affinity Capture-Western
SLC9A3R1P2RY11110679671706 Reconstituted Complex
SLC9A3R1P2RY11147699671706 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:105049
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018