AutismKB 2.0

Annotation Details for SERPINE1


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Basic Information Top
Gene Symbol:SERPINE1 ( PAI,PAI-1,PAI1,PLANH1 )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Band: 7q22.1
Quick LinksEntrez ID:5054; OMIM: 173360; Uniprot ID:PAI1_HUMAN; ENSEMBL ID: ENSG00000106366; HGNC ID: 8583
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region9386191
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space1695900
GO:0005886TAS-plasma membrane-
GO:0031012IDA-extracellular matrix1632457
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome21276792
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding2503541
GO:0004867IDA-serine-type endopeptidase inhibitor activity1695900
GO:0004867TAS-serine-type endopeptidase inhibitor activity-
GO:0005102IPI-receptor binding8626514
GO:0005515IPI-protein binding16272158
GO ID Evidence Qualifier GO_term References
GO:0001300IEP-chronological cell aging18974388
GO:0001525IEP-angiogenesis11866539
GO:0002576TAS-platelet degranulation-
GO:0007623TAS-circadian rhythm-
GO:0010469IDA-regulation of receptor activity8837777
GO:0010757IDA-negative regulation of plasminogen activation8508955
GO:0010757IMP-negative regulation of plasminogen activation18835034
GO:0010951IDA-negative regulation of endopeptidase activity1695900
GO:0014912IDA-negative regulation of smooth muscle cell migration8837777
GO:0030194IMP-positive regulation of blood coagulation9207454
GO:0030195IC-negative regulation of blood coagulation1695900
GO:0030198TAS-extracellular matrix organization-
GO:0030336IDA-negative regulation of cell migration10902815
GO:0032757IMP-positive regulation of interleukin-8 production19916862
GO:0033629IDA-negative regulation of cell adhesion mediated by integrin8837777
GO:0035491IMP-positive regulation of leukotriene production involved in inflammatory response19916862
GO:0042730TAS-fibrinolysis-
GO:0045766IMP-positive regulation of angiogenesis18835034
GO:0045944TAS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048260IDA-positive regulation of receptor-mediated endocytosis8626514
GO:0050729IGI-positive regulation of inflammatory response17032919
GO:0050829IGI-defense response to Gram-negative bacterium17032919
GO:0051918IDA-negative regulation of fibrinolysis2503541
GO:0061044IGI-negative regulation of vascular wound healing9386191
GO:0061045IC-negative regulation of wound healing8837777
GO:0071222IMP-cellular response to lipopolysaccharide19916862
GO:0090026IMP-positive regulation of monocyte chemotaxis19916862
GO:1902042IMP-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors18835034
GO:2000098IDA-negative regulation of smooth muscle cell-matrix adhesion8837777
GO:2000352IMP-negative regulation of endothelial cell apoptotic process18835034
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SERPINE1F210844712709053 Reconstituted Complex
SERPINE1F211109112709053 Reconstituted Complex
SERPINE1IGFBP51097099202242 Affinity Capture-Western
SERPINE1IGFBP51110919202242 Affinity Capture-Western
SERPINE1LRP111021515001579 Affinity Capture-Western
SERPINE1LRP111109115001579 Affinity Capture-Western
SERPINE1ORM111104611418606 Reconstituted Complex; Two-hybrid
SERPINE1ORM111109111418606 Reconstituted Complex; Two-hybrid
PLATSERPINE11113432110366 Reconstituted Complex
PLATSERPINE11110912110366 Reconstituted Complex
PLAUSERPINE11113449184208 Reconstituted Complex
PLAUSERPINE11110919184208 Reconstituted Complex
SERPINE1SERPINE111109110731421 Co-crystal Structure
PLGSERPINE111135611113116 Reconstituted Complex
PLGSERPINE111109111113116 Reconstituted Complex
VTNSERPINE111328711113116 Reconstituted Complex
VTNSERPINE111109111113116 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SERPINE1rs11178, rs1799889, rs2227631, rs2227662, rs2227692 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:97608
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070912-60'