AutismKB 2.0

Annotation Details for PAK1


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Basic Information Top
Gene Symbol:PAK1 ( MGC130000,MGC130001,PAKalpha )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 1
Band: 11q13.5-q14.1
Quick LinksEntrez ID:5058; OMIM: 602590; Uniprot ID:PAK1_HUMAN; ENSEMBL ID: ENSG00000149269; HGNC ID: 8590
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IDA-ruffle12912914
GO:0005737IDA-cytoplasm16278681
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane16278681
GO:0005886TAS-plasma membrane-
GO:0005911IDA-cell-cell junction12912914
GO:0005925IEA-focal adhesion-
GO:0014704ISS-intercalated disc-
GO:0030018ISS-Z disc-
GO:0030027IEA-lamellipodium-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0031941NAScolocalizes_withfilamentous actin9395435
GO:0031965ISS-nuclear membrane-
GO:0032587IEA-ruffle membrane-
GO:0043234IDA-protein complex11864573
GO:0071437IDA-invadopodium25766321
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity8805275
GO:0004674EXP-protein serine/threonine kinase activity10075701
GO:0004674IDA-protein serine/threonine kinase activity16278681
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005515IPI-protein binding10026169
GO:0005515IPIcontributes_toprotein binding11950598
GO:0005518IPI-collagen binding12189148
GO:0005524IEA-ATP binding-
GO:0019901IEA-protein kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0000165IDANOTMAPK cascade8805275
GO:0000278IBANOTmitotic cell cycle-
GO:0001666IEA-response to hypoxia-
GO:0001934IMP-positive regulation of protein phosphorylation23633677
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006468IDA-protein phosphorylation9852149
GO:0006887IEA-exocytosis-
GO:0006915IEA-apoptotic process-
GO:0007409IBA-axonogenesis-
GO:0008284IMP-positive regulation of cell proliferation23333386
GO:0010763IEA-positive regulation of fibroblast migration-
GO:0021549IEA-cerebellum development-
GO:0030010IEA-establishment of cell polarity-
GO:0030335IDA-positive regulation of cell migration25766321
GO:0031116IMP-positive regulation of microtubule polymerization25198505
GO:0031295TAS-T cell costimulation-
GO:0031532IDA-actin cytoskeleton reorganization9395435
GO:0031532IMP-actin cytoskeleton reorganization16278681
GO:0032869IEA-cellular response to insulin stimulus-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19667065
GO:0033148IDA-positive regulation of intracellular estrogen receptor signaling pathway16278681
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042060IMP-wound healing12912914
GO:0043507IMP-positive regulation of JUN kinase activity8805275
GO:0045773IEA-positive regulation of axon extension-
GO:0046777IDA-protein autophosphorylation8805275
GO:0048012IMP-hepatocyte growth factor receptor signaling pathway25198505
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048754IMP-branching morphogenesis of an epithelial tube20457839
GO:0048812ISS-neuron projection morphogenesis-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051496IMP-positive regulation of stress fiber assembly11864573
GO:0060244IMP-negative regulation of cell proliferation involved in contact inhibition12912914
GO:0061052IEA-negative regulation of cell growth involved in cardiac muscle cell development-
GO:0090314IEA-positive regulation of protein targeting to membrane-
GO:1904707IEA-positive regulation of vascular smooth muscle cell proliferation-
GO:1904754IEA-positive regulation of vascular associated smooth muscle cell migration-
GO:2001275IEA-positive regulation of glucose import in response to insulin stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PAK1AKT110671014749719 Reconstituted Complex
PAK1AKT111109514749719 Reconstituted Complex
PAK1BMX10712811382770 Affinity Capture-Western; Reconstituted Complex
PAK1BMX11109511382770 Affinity Capture-Western; Reconstituted Complex
PAK1CDC421074339535855 12650940 20936779 Reconstituted Complex; Two-hybrid
PAK1CDC421110959535855 12650940 20936779 Reconstituted Complex; Two-hybrid
PAK1CDK510745511604394 Affinity Capture-Western; Biochemical Activity
PAK1CDK511109511604394 Affinity Capture-Western; Biochemical Activity
PAK1ERBB21083769774445 Affinity Capture-Western
PAK1ERBB21110959774445 Affinity Capture-Western
PAK1HSP90AA111109520936779 Two-hybrid
PAK1HSP90AA110955220936779 Two-hybrid
PAK1LIMK111109510559936 Affinity Capture-Western; Reconstituted Complex
PAK1LIMK111017210559936 Affinity Capture-Western; Reconstituted Complex
PAK1MYLK11072210092231 Biochemical Activity
PAK1MYLK11109510092231 Biochemical Activity
PAK1NCK11107708824201 10026169 11157752 Affinity Capture-Western; Reconstituted Complex
PAK1NCK11110958824201 10026169 11157752 Affinity Capture-Western; Reconstituted Complex
RAC1PAK11110959535855 12650940 12879077 20936779 Reconstituted Complex; Two-hybrid
RAC1PAK11118179535855 12650940 12879077 20936779 Reconstituted Complex; Two-hybrid
NCK2PAK111109510026169 Affinity Capture-Western
NCK2PAK111402010026169 Affinity Capture-Western
RHOJPAK111109510967094 Two-hybrid
RHOJPAK112149910967094 Two-hybrid
PAK1PAK111109510975528 11804587 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation
BAIAP2PAK111109511130076 Reconstituted Complex
BAIAP2PAK111572111130076 Reconstituted Complex
ARHGEF7PAK111439311157752 16407834 20936779 Affinity Capture-Western; Two-hybrid
ARHGEF7PAK111109511157752 16407834 20936779 Affinity Capture-Western; Two-hybrid
PAK1IP1PAK111109511371639 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PAK1IP1PAK112033511371639 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HGSPAK111109511397816 Reconstituted Complex
HGSPAK111459311397816 Reconstituted Complex
RAF1PAK111183111733498 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAF1PAK111109511733498 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ABI3PAK111109511956071 Reconstituted Complex
ABI3PAK111938911956071 Reconstituted Complex
PKLRPAK111109512006652 Affinity Capture-Western
PKLRPAK111133012006652 Affinity Capture-Western
PLCG1PAK111109512085993 Reconstituted Complex
PLCG1PAK111135112085993 Reconstituted Complex
CDK11APAK111109512624090 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CDK11APAK160906412624090 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARPC1BPAK111109514749719 Affinity Capture-Western; Reconstituted Complex
ARPC1BPAK111540214749719 Affinity Capture-Western; Reconstituted Complex
ARHGEF2PAK111109514970201 Affinity Capture-MS; Reconstituted Complex
ARHGEF2PAK111461814970201 Affinity Capture-MS; Reconstituted Complex
DYNLL1PAK111109515193260 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
DYNLL1PAK111420615193260 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
SH3KBP1PAK111109516407834 Affinity Capture-Western
SH3KBP1PAK111902916407834 Affinity Capture-Western
ZNF238PAK111109520936779 Two-hybrid
ZNF238PAK111573520936779 Two-hybrid
ZNF418PAK111109520936779 Two-hybrid
ZNF418PAK112707420936779 Two-hybrid
ZC3H7APAK111109520936779 Two-hybrid
ZC3H7APAK111884120936779 Two-hybrid
ZNF823PAK111109520936779 Two-hybrid
ZNF823PAK112071320936779 Two-hybrid
ZNF83PAK111109520936779 Two-hybrid
ZNF83PAK112088620936779 Two-hybrid
MYNNPAK111109520936779 Two-hybrid
MYNNPAK112098220936779 Two-hybrid
C5orf42PAK111109520936779 Two-hybrid
C5orf42PAK112241320936779 Two-hybrid
YWHAGPAK111109520936779 Two-hybrid
YWHAGPAK111336420936779 Two-hybrid
YWHAZPAK111109520936779 Two-hybrid
YWHAZPAK111336620936779 Two-hybrid
DYRK1BPAK111109520936779 Two-hybrid
DYRK1BPAK111459620936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
PAK1CDC4230090512944407 Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1.
PAK1CDC4229747815864311 PAK1 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1339975
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030826-29'