AutismKB 2.0

Annotation Details for ARHGEF3


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Basic Information Top
Gene Symbol:ARHGEF3 ( DKFZp434F2429,FLJ98126,GEF3,MGC118905,STA3,XPLN )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 3
Band: 3p14.3
Quick LinksEntrez ID:50650; OMIM: 612115; Uniprot ID:ARHG3_HUMAN; ENSEMBL ID: ENSG00000163947; HGNC ID: 683
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IDA-intracellular-
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding25416956
GO ID Evidence Qualifier GO_term References
GO:0007266TAS-Rho protein signal transduction10873612
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ARHGEF3RHOA11911512221096 Biochemical Activity; Reconstituted Complex
ARHGEF3RHOA10688012221096 Biochemical Activity; Reconstituted Complex
ARHGEF3RHOB11911512221096 Biochemical Activity; Reconstituted Complex
ARHGEF3RHOB10688112221096 Biochemical Activity; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1918954
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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