AutismKB 2.0

Annotation Details for PARK2


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Basic Information Top
Gene Symbol:PARK2 ( AR-JP,LPRS2,PDJ,PRKN )
Gene Full Name: parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Band: 6q25.2-q27
Quick LinksEntrez ID:5071; OMIM: 602544; Uniprot ID:PRKN2_HUMAN; ENSEMBL ID: ENSG00000185345; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151IDA-ubiquitin ligase complex12150907
GO:0005634IDA-nucleus23985028
GO:0005737IDA-cytoplasm17512523
GO:0005739IDA-mitochondrion19229105
GO:0005739IMP-mitochondrion19029340
GO:0005739IMPcolocalizes_withmitochondrion21508222
GO:0005783IDA-endoplasmic reticulum12150907
GO:0005794IDA-Golgi apparatus17097639
GO:0005829IDA-cytosol19029340
GO:0005829IMP-cytosol21508222
GO:0005829TAS-cytosol-
GO:0016235IDA-aggresome14645198
GO:0019005IDANOTSCF ubiquitin ligase complex12628165
GO:0043005IDA-neuron projection12925569
GO:0043234IEA-protein complex-
GO:0048471IDA-perinuclear region of cytoplasm17097639
GO:0071797IPIcolocalizes_withLUBAC complex23453807
GO:0097413TAS-Lewy body24522549
GO:0098793IEA-presynapse-
GO:0099073IDAcolocalizes_withmitochondrion-derived vesicle24446486
GO:1990452IPI-Parkin-FBXW7-Cul1 ubiquitin ligase complex12628165
GO ID Evidence Qualifier GO_term References
GO:0000976IDA-transcription regulatory region sequence-specific DNA binding23985028
GO:0001664IPI-G-protein coupled receptor binding12150907
GO:0003700IC-transcription factor activity, sequence-specific DNA binding23985028
GO:0003779IPI-actin binding21753002
GO:0004842IDA-ubiquitin-protein transferase activity11078524
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding10888878
GO:0008013IDA-beta-catenin binding19591802
GO:0008270TAS-zinc ion binding23626584
GO:0015631IPI-tubulin binding21753002
GO:0017124TAS-SH3 domain binding23626584
GO:0019899IPI-enzyme binding19725078
GO:0019900IPI-kinase binding17512523
GO:0019901IPI-protein kinase binding20798600
GO:0030165IPI-PDZ domain binding17512523
GO:0030544IPI-Hsp70 protein binding12150907
GO:0031072IPI-heat shock protein binding12150907
GO:0031624IDA-ubiquitin conjugating enzyme binding10973942
GO:0031624IPI-ubiquitin conjugating enzyme binding11439185
GO:0031625IPI-ubiquitin protein ligase binding12150907
GO:0042802IPI-identical protein binding21694720
GO:0042826IPI-histone deacetylase binding21753002
GO:0043130IDA-ubiquitin binding24784582
GO:0043274IPI-phospholipase binding19725078
GO:0051087IPI-chaperone binding15603737
GO:0061630IDA-ubiquitin protein ligase activity10973942
GO:0061630NAS-ubiquitin protein ligase activity18221368
GO:0061630TAS-ubiquitin protein ligase activity-
GO:0097602IDA-cullin family protein binding12628165
GO:1904264NAS-ubiquitin protein ligase activity involved in ERAD pathway10973942
GO:1990381IPI-ubiquitin-specific protease binding24063750
GO:1990444IPI-F-box domain binding12628165
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter23985028
GO:0000209IDA-protein polyubiquitination12150907
GO:0000266ISS-mitochondrial fission-
GO:0000422IDA-mitophagy25621951
GO:0000422IMP-mitophagy19029340
GO:0000423IEA-macromitophagy-
GO:0001933IDA-negative regulation of protein phosphorylation17512523
GO:0001964IEA-startle response-
GO:0006351IEA-transcription, DNA-templated-
GO:0006513IDA-protein monoubiquitination20889974
GO:0006513IMP-protein monoubiquitination24660806
GO:0006979ISS-response to oxidative stress-
GO:0007005ISS-mitochondrion organization-
GO:0007417TAS-central nervous system development9560156
GO:0007612IEA-learning-
GO:0008344ISS-adult locomotory behavior-
GO:0010498IMP-proteasomal protein catabolic process19725078
GO:0010506IDA-regulation of autophagy20889974
GO:0010628IMP-positive regulation of gene expression19725078
GO:0010629IMP-negative regulation of gene expression19725078
GO:0010636IMP-positive regulation of mitochondrial fusion23453807
GO:0010637ISS-negative regulation of mitochondrial fusion-
GO:0010821IDA-regulation of mitochondrion organization21113145
GO:0010821IGI-regulation of mitochondrion organization19279012
GO:0010821NAS-regulation of mitochondrion organization20890124
GO:0010906TAS-regulation of glucose metabolic process23626584
GO:0010994IMP-free ubiquitin chain polymerization24660806
GO:0014059TAS-regulation of dopamine secretion21563316
GO:0016236TAS-macroautophagy-
GO:0016567IDA-protein ubiquitination10973942
GO:0016567IMP-protein ubiquitination23933751
GO:0016579TAS-protein deubiquitination-
GO:0030433IEA-ubiquitin-dependent ERAD pathway-
GO:0031396IGI-regulation of protein ubiquitination23212910
GO:0031396IMP-regulation of protein ubiquitination20871098
GO:0031647IMP-regulation of protein stability26911690
GO:0031648IDA-protein destabilization19591802
GO:0032092IMP-positive regulation of protein binding26911690
GO:0032232IDA-negative regulation of actin filament bundle assembly17512523
GO:0032368TAS-regulation of lipid transport23626584
GO:0032436TAS-positive regulation of proteasomal ubiquitin-dependent protein catabolic process24115276
GO:0033132IDA-negative regulation of glucokinase activity24187134
GO:0034620TAS-cellular response to unfolded protein18221368
GO:0034976IMP-response to endoplasmic reticulum stress21113145
GO:0035249IEA-synaptic transmission, glutamatergic-
GO:0035519TAS-protein K29-linked ubiquitination23626584
GO:0036503NAS-ERAD pathway10973942
GO:0042053IMP-regulation of dopamine metabolic process22314364
GO:0042415IEA-norepinephrine metabolic process-
GO:0042417TAS-dopamine metabolic process23626584
GO:0042787IC-protein ubiquitination involved in ubiquitin-dependent protein catabolic process21376232
GO:0042787IDA-protein ubiquitination involved in ubiquitin-dependent protein catabolic process12925569
GO:0042787NAS-protein ubiquitination involved in ubiquitin-dependent protein catabolic process12628165
GO:0042787TAS-protein ubiquitination involved in ubiquitin-dependent protein catabolic process10888878
GO:0043123IDA-positive regulation of I-kappaB kinase/NF-kappaB signaling17314283
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling23453807
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process11439185
GO:0043388IDA-positive regulation of DNA binding17314283
GO:0043524IDA-negative regulation of neuron apoptotic process12628165
GO:0044257IMP-cellular protein catabolic process21376232
GO:0044267TAS-cellular protein metabolic process-
GO:0044314TAS-protein K27-linked ubiquitination20098416
GO:0044828IDA-negative regulation by host of viral genome replication25244949
GO:0045732TAS-positive regulation of protein catabolic process22988876
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter23453807
GO:0046329ISS-negative regulation of JNK cascade-
GO:0046676IDA-negative regulation of insulin secretion24187134
GO:0050821IMP-protein stabilization19229105
GO:0051582IMP-positive regulation of neurotransmitter uptake22314364
GO:0051583IEA-dopamine uptake involved in synaptic transmission-
GO:0051865IDA-protein autoubiquitination12628165
GO:0051881IEA-regulation of mitochondrial membrane potential-
GO:0055069ISS-zinc ion homeostasis-
GO:0060548IDA-negative regulation of cell death15603737
GO:0060828TAS-regulation of canonical Wnt signaling pathway24115276
GO:0061734IDA-parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization19029340
GO:0070050ISS-neuron cellular homeostasis-
GO:0070534IDA-protein K63-linked ubiquitination15728840
GO:0070534NAS-protein K63-linked ubiquitination20890124
GO:0070534TAS-protein K63-linked ubiquitination18221368
GO:0070585IEA-protein localization to mitochondrion-
GO:0070842IMP-aggresome assembly14645198
GO:0070936IDA-protein K48-linked ubiquitination21376232
GO:0070979IDA-protein K11-linked ubiquitination25621951
GO:0071287TAS-cellular response to manganese ion23628791
GO:0085020IDA-protein K6-linked ubiquitination25621951
GO:0085020TAS-protein K6-linked ubiquitination23626584
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway19591802
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway22988876
GO:0090141ISS-positive regulation of mitochondrial fission-
GO:0090201IDA-negative regulation of release of cytochrome c from mitochondria19880420
GO:0097237IMP-cellular response to toxic substance12628165
GO:0098779IDA-positive regulation of macromitophagy in response to mitochondrial depolarization20457763
GO:0098779IMP-positive regulation of macromitophagy in response to mitochondrial depolarization20871098
GO:0099074IDA-mitochondrion to lysosome transport24446486
GO:1900407IDA-regulation of cellular response to oxidative stress24446486
GO:1900407IMP-regulation of cellular response to oxidative stress22314364
GO:1900407ISS-regulation of cellular response to oxidative stress-
GO:1901215IGI-negative regulation of neuron death21376232
GO:1901800IGI-positive regulation of proteasomal protein catabolic process23858059
GO:1902236IDA-negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway11439185
GO:1902236IMP-negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway10973942
GO:1902254IMP-negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator23985028
GO:1902283IMP-negative regulation of primary amine oxidase activity22314364
GO:1902530IGI-positive regulation of protein linear polyubiquitination23453807
GO:1902803NAS-regulation of synaptic vesicle transport21563316
GO:1903202NAS-negative regulation of oxidative stress-induced cell death24522549
GO:1903202TAS-negative regulation of oxidative stress-induced cell death24252804
GO:1903214NAS-regulation of protein targeting to mitochondrion20890124
GO:1903265IDA-positive regulation of tumor necrosis factor-mediated signaling pathway23453807
GO:1903351TAS-cellular response to dopamine23626584
GO:1903377IDA-negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway17314283
GO:1903378IEA-positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway-
GO:1903382IEA-negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway-
GO:1903542IMP-negative regulation of exosomal secretion26911690
GO:1903599IDA-positive regulation of mitophagy26310625
GO:1903599ISS-positive regulation of mitophagy-
GO:1903861IEA-positive regulation of dendrite extension-
GO:1904049IMP-negative regulation of spontaneous neurotransmitter secretion22314364
GO:1905281NAS-positive regulation of retrograde transport, endosome to Golgi26911690
GO:1905366IMP-negative regulation of intralumenal vesicle formation26911690
GO:1905477IC-positive regulation of protein localization to membrane26911690
GO:1905477IMP-positive regulation of protein localization to membrane26911690
GO:2000377IMP-regulation of reactive oxygen species metabolic process18541373
GO:2000378IGI-negative regulation of reactive oxygen species metabolic process18541373
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PARK2BACH111110517682061 Affinity Capture-Western
PARK2BACH110704717682061 Affinity Capture-Western
PARK2CAMK2A11110511679592 Affinity Capture-Western
PARK2CAMK2A10726511679592 Affinity Capture-Western
PARK2CCNE111110512628165 Affinity Capture-Western
PARK2CCNE110733812628165 Affinity Capture-Western
PARK2CDK511110517327227 Affinity Capture-Western; Biochemical Activity
PARK2CDK510745517327227 Affinity Capture-Western; Biochemical Activity
PARK2DLG411110511679592 Affinity Capture-Western
PARK2DLG410808611679592 Affinity Capture-Western
PARK2EP30010834719297328 Affinity Capture-Western
PARK2EP30011110519297328 Affinity Capture-Western
PARK2EPS1511110516862145 Biochemical Activity; Reconstituted Complex
PARK2EPS1510837416862145 Biochemical Activity; Reconstituted Complex
PARK2GPR3711110511439185 12150907 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PARK2GPR3710911911439185 12150907 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PARK2GRIN2B11110511679592 Affinity Capture-Western
PARK2GRIN2B10916111679592 Affinity Capture-Western
PARK2DNAJA110953412150907 Affinity Capture-Western
PARK2DNAJA111110512150907 Affinity Capture-Western
PARK2HSPA1A10953512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PARK2HSPA1A11110512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PARK2HSPA411110512676955 16714300 18248624 Affinity Capture-Western
PARK2HSPA410954012676955 16714300 18248624 Affinity Capture-Western
PARK2HSPA811110512150907 Affinity Capture-Western; Reconstituted Complex
PARK2HSPA810954412150907 Affinity Capture-Western; Reconstituted Complex
PARK2DNAJB111110512150907 Affinity Capture-Western
PARK2DNAJB110956912150907 Affinity Capture-Western
PARK2LIMK111110517512523 Affinity Capture-Western
PARK2LIMK111017217512523 Affinity Capture-Western
PARK2MAPT11030814962978 18248624 Affinity Capture-Western
PARK2MAPT11110514962978 18248624 Affinity Capture-Western
PARK2PAFAH1B211110516169070 Two-hybrid
PARK2PAFAH1B211108616169070 Two-hybrid
UBE2L6PARK211110511078524 Affinity Capture-Western
UBE2L6PARK211467211078524 Affinity Capture-Western
SYN1PARK211110511431533 Affinity Capture-Western
SYN1PARK211271911431533 Affinity Capture-Western
UBE2L3PARK211110511431533 Affinity Capture-Western
UBE2L3PARK211318011431533 Affinity Capture-Western
UBE2J1PARK211110511439185 Affinity Capture-Western
UBE2J1PARK211955511439185 Affinity Capture-Western
UBE2G1PARK211110511439185 Affinity Capture-Western
UBE2G1PARK211317411439185 Affinity Capture-Western
SNCAPARK211110511588587 16714300 18195004 Affinity Capture-Western
SNCAPARK211250611588587 16714300 18195004 Affinity Capture-Western
SNCAIPPARK211110511590439 15944382 16049031 Affinity Capture-Western; Biochemical Activity
SNCAIPPARK211498611590439 15944382 16049031 Affinity Capture-Western; Biochemical Activity
HOMER1PARK211110511679592 Affinity Capture-Western
HOMER1PARK211484511679592 Affinity Capture-Western
CASKPARK211110511679592 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CASKPARK211414111679592 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
STUB1PARK211110512150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
STUB1PARK211556312150907 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PSMA1PARK211110512150907 Reconstituted Complex
PSMA1PARK211165512150907 Reconstituted Complex
CCNA1PARK211110512628165 Affinity Capture-Western
CCNA1PARK211441712628165 Affinity Capture-Western
FBXW7PARK212058112628165 Affinity Capture-Western; Reconstituted Complex
FBXW7PARK211110512628165 Affinity Capture-Western; Reconstituted Complex
CUL1PARK211110512628165 Affinity Capture-Western; Reconstituted Complex
CUL1PARK211403212628165 Affinity Capture-Western; Reconstituted Complex
PSMC5PARK211110512676955 Affinity Capture-Western; Reconstituted Complex
PSMC5PARK211167812676955 Affinity Capture-Western; Reconstituted Complex
AIMP2PARK211110512783850 16049031 16135753 16714300 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
AIMP2PARK211368412783850 16049031 16135753 16714300 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYT11PARK211110512925569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SYT11PARK211681512925569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TUBG1PARK211110512928331 16714300 Affinity Capture-Western
TUBG1PARK211313412928331 16714300 Affinity Capture-Western
SEPT5PARK211110514559152 16714300 18845538 Affinity Capture-Western; Biochemical Activity; Two-hybrid
SEPT5PARK211141414559152 16714300 18845538 Affinity Capture-Western; Biochemical Activity; Two-hybrid
SLC6A3PARK211110515492001 Affinity Capture-Western
SLC6A3PARK211242215492001 Affinity Capture-Western
PARK7PARK211110515525661 17846173 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PARK7PARK211644615525661 17846173 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SIM2PARK211110515963499 Affinity Capture-Western
SIM2PARK211238415963499 Affinity Capture-Western
PSMA4PARK211110515987638 16714300 Affinity Capture-Western; Two-hybrid
PSMA4PARK211165815987638 16714300 Affinity Capture-Western; Two-hybrid
UBCPARK211110516049031 16352719 16714300 17327227 17512523 18195004 18541373 Affinity Capture-Western
UBCPARK211316416049031 16352719 16714300 17327227 17512523 18195004 18541373 Affinity Capture-Western
NDUFA4L2PARK212123116169070 Two-hybrid
NDUFA4L2PARK211110516169070 Two-hybrid
RAD1PARK211110516169070 Two-hybrid
RAD1PARK211177116169070 Two-hybrid
RAC1PARK211110516169070 Two-hybrid
RAC1PARK211181716169070 Two-hybrid
RGS2PARK211192916169070 Two-hybrid
RGS2PARK211110516169070 Two-hybrid
TRIP13PARK211110516189514 Two-hybrid
TRIP13PARK211473016189514 Two-hybrid
HDAC4PARK211510616332688 Affinity Capture-Western
HDAC4PARK211110516332688 Affinity Capture-Western
RANBP2PARK211110516332688 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RANBP2PARK211183916332688 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LRRK2PARK211110516352719 Affinity Capture-Western
LRRK2PARK212570016352719 Affinity Capture-Western
TUBA1APARK211110516714300 Affinity Capture-Western
TUBA1APARK211360316714300 Affinity Capture-Western
PARK2PARK211110516714300 17883392 Affinity Capture-Western; Biochemical Activity
RNF41PARK211110518541373 Biochemical Activity
RNF41PARK211548818541373 Biochemical Activity
PLCG1PARK211110518671761 Affinity Capture-Western
PLCG1PARK211135118671761 Affinity Capture-Western
PDCD2PARK211116119146857 Affinity Capture-Western; Biochemical Activity
PDCD2PARK211110519146857 Affinity Capture-Western; Biochemical Activity
Gene Symbol Interactant Interaction ID References Description
BAG5PARK219596515603737 BAG5 interacts with parkin.
SNCAIPPARK219632215603737 Synphilin interacts with parkin.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
PARK2PARK2_111G/A, PARK2_1514C/A, PARK2_2bpSTR, PARK2_957T/C, PARK2_A339S, PARK2_CNV, PARK2_H124H, PARK2_IVS2+35G>A, PARK2_IVS2+62G>A, PARK2_IVS3-82C>A, PARK2_IVS4-77C>T, PARK2_Q100H, PARK2_R271S, PARK_IVS2-18T>A, rs10945756, rs10945859, rs1801334, rs1801474, rs1801582, rs1893540, rs2075923, rs2276201, rs2849520, rs3765474, rs3765475, rs4709583, rs505319, rs56092260, rs68144677, rs9456711, rs9456735 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:1355296
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050417-109'