AutismKB 2.0

Annotation Details for PARN


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Basic Information Top
Gene Symbol:PARN ( DAN )
Gene Full Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Band: 16p13.12
Quick LinksEntrez ID:5073; OMIM: 604212; Uniprot ID:PARN_HUMAN; ENSEMBL ID: ENSG00000140694; HGNC ID: 8609
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634TAS-nucleus9736620
GO:0005730IEA-nucleolus-
GO:0005737TAS-cytoplasm9736620
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003730TAS-mRNA 3'-UTR binding9736620
GO:0004518TAS-nuclease activity9736620
GO:0004535IMP-poly(A)-specific ribonuclease activity26482878
GO:0004535TAS-poly(A)-specific ribonuclease activity-
GO:0005515IPI-protein binding20379136
GO:0019901IPI-protein kinase binding20932473
GO:0043169IMP-cation binding15358788
GO:0046872IEA-metal ion binding-
GO:0070034IC-telomerase RNA binding26482878
GO ID Evidence Qualifier GO_term References
GO:0000184IEA-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-
GO:0000289TAS-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0007292TAS-female gamete generation9736620
GO:0009451TAS-RNA modification9736620
GO:0032212IMP-positive regulation of telomere maintenance via telomerase26482878
GO:0043488TAS-regulation of mRNA stability-
GO:0051973IMP-positive regulation of telomerase activity26482878
GO:0090503IMP-RNA phosphodiester bond hydrolysis, exonucleolytic26482878
GO:0090669IMP-telomerase RNA stabilization26482878
GO:0110008IMP-ncRNA deadenylation26482878
GO:1904872IMP-regulation of telomerase RNA localization to Cajal body26950371
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
UPF2PARN11110714527413 Affinity Capture-Western
UPF2PARN11749014527413 Affinity Capture-Western
UPF1PARN11110714527413 Affinity Capture-Western
UPF1PARN11190814527413 Affinity Capture-Western
UPF3APARN11110714527413 Affinity Capture-Western
UPF3APARN12239714527413 Affinity Capture-Western
KHSRPPARN11110715175153 Affinity Capture-Western
KHSRPPARN11413915175153 Affinity Capture-Western
C21orf56PARN11110715231747 Two-hybrid
C21orf56PARN12395515231747 Two-hybrid
SUMO2PARN11249719394292 Affinity Capture-MS
SUMO2PARN11110719394292 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1921358
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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