AutismKB 2.0

Annotation Details for PAX6


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Basic Information Top
Gene Symbol:PAX6 ( AN,AN2,D11S812E,MGC17209,MGDA,WAGR )
Gene Full Name: paired box 6
Band: 11p13
Quick LinksEntrez ID:5080; OMIM: 607108; Uniprot ID:PAX6_HUMAN; ENSEMBL ID: ENSG00000007372; HGNC ID: 8620
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin20592023
GO:0005634IDA-nucleus17291498
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm17291498
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000979IDA-RNA polymerase II core promoter sequence-specific DNA binding20592023
GO:0000981IDA-RNA polymerase II transcription factor activity, sequence-specific DNA binding20592023
GO:0003677TAS-DNA binding10441571
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding10441571
GO:0004842ISS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding16098226
GO:0008134ISS-transcription factor binding-
GO:0019901ISS-protein kinase binding-
GO:0035035ISS-histone acetyltransferase binding-
GO:0070412IPI-R-SMAD binding17251190
GO ID Evidence Qualifier GO_term References
GO:0001568IMP-blood vessel development7550230
GO:0001654TAS-eye development10747901
GO:0003322IMP-pancreatic A cell development20592023
GO:0006366IMP-transcription from RNA polymerase II promoter20592023
GO:0007417TAS-central nervous system development10747901
GO:0007601TAS-visual perception10441571
GO:0009611IEP-response to wounding17982423
GO:0009887TAS-animal organ morphogenesis10441571
GO:0010628IMP-positive regulation of gene expression20592023
GO:0016567IEA-protein ubiquitination-
GO:0042593IMP-glucose homeostasis11756345
GO:0045893IMP-positive regulation of transcription, DNA-templated20592023
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048663NAS-neuron fate commitment17291498
GO:0050768ISS-negative regulation of neurogenesis-
GO:0061072IMP-iris morphogenesis7550230
GO:0061303IMP-cornea development in camera-type eye7550230
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PAX6CDX211111410506141 Affinity Capture-Western; Reconstituted Complex
PAX6CDX210747510506141 Affinity Capture-Western; Reconstituted Complex
PAX6EN111111411069920 Reconstituted Complex
PAX6EN110833411069920 Reconstituted Complex
PAX6EP30010834710506141 Affinity Capture-Western; Reconstituted Complex
PAX6EP30011111410506141 Affinity Capture-Western; Reconstituted Complex
PAX6HOXB111111411069920 Reconstituted Complex
PAX6HOXB110945111069920 Reconstituted Complex
PAX6MITF11111411350962 Reconstituted Complex
PAX6MITF11043211350962 Reconstituted Complex
TAF1PAX611273510359315 Affinity Capture-Western
TAF1PAX611111410359315 Affinity Capture-Western
TBPPAX611111410359315 Affinity Capture-Western; Reconstituted Complex
TBPPAX611277110359315 Affinity Capture-Western; Reconstituted Complex
RB1PAX611111410359315 Reconstituted Complex
RB1PAX611186010359315 Reconstituted Complex
RAXPAX611903411069920 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
RAXPAX611111411069920 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
PAX6PAX611111411069920 Affinity Capture-Western; Reconstituted Complex
VSX2PAX613081311069920 Reconstituted Complex
VSX2PAX611111411069920 Reconstituted Complex
PKNOX1PAX611133311069920 Reconstituted Complex
PKNOX1PAX611111411069920 Reconstituted Complex
PROX1PAX611161311069920 Reconstituted Complex
PROX1PAX611111411069920 Reconstituted Complex
SIX3PAX611111411069920 Reconstituted Complex
SIX3PAX611238711069920 Reconstituted Complex
LHX2PAX611475811069920 Reconstituted Complex
LHX2PAX611111411069920 Reconstituted Complex
SOX2PAX611254012710953 Affinity Capture-Western
SOX2PAX611111412710953 Affinity Capture-Western
IPO13PAX611111415143176 16189514 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IPO13PAX611502515143176 16189514 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMARCA4PAX611248116675956 Affinity Capture-Western
SMARCA4PAX611111416675956 Affinity Capture-Western
TP73PAX611301420308539 Affinity Capture-Western
TP73PAX611111420308539 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PAX6PAX6_(AC)m(AG)n Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97490
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-001031-1'