AutismKB 2.0

Annotation Details for FOXP3


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Basic Information Top
Gene Symbol:FOXP3 ( AIID,DIETER,IPEX,MGC141961,MGC141963,PIDX,XPID )
Gene Full Name: forkhead box P3
Band: Xp11.23
Quick LinksEntrez ID:50943; OMIM: 300292; Uniprot ID:FOXP3_HUMAN; ENSEMBL ID: ENSG00000049768; HGNC ID: 6106
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11483607
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm22678915
GO:0043234NAS-protein complex16903909
GO ID Evidence Qualifier GO_term References
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0001047ISS-core promoter binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding11483607
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding11138001
GO:0003705IEA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0003714IEA-transcription corepressor activity-
GO:0005515IPI-protein binding16652169
GO:0035035IPI-histone acetyltransferase binding17360565
GO:0042803IPI-protein homodimerization activity16920951
GO:0042826IPI-histone deacetylase binding17360565
GO:0043565IDA-sequence-specific DNA binding11483607
GO:0046872IEA-metal ion binding-
GO:0051059NAS-NF-kappaB binding16652169
GO:0051525IPI-NFAT protein binding16873067
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001782IEA-B cell homeostasis-
GO:0001816IEA-cytokine production-
GO:0002262IEA-myeloid cell homeostasis-
GO:0002362TAS-CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment18368049
GO:0002456IEA-T cell mediated immunity-
GO:0002513IEA-tolerance induction to self antigen-
GO:0002667ISS-regulation of T cell anergy-
GO:0002669IEA-positive regulation of T cell anergy-
GO:0002677IEA-negative regulation of chronic inflammatory response-
GO:0002725IDA-negative regulation of T cell cytokine production15466453
GO:0002725IMP-negative regulation of T cell cytokine production23169781
GO:0002851IEA-positive regulation of peripheral T cell tolerance induction-
GO:0006338NAS-chromatin remodeling16903909
GO:0006351IEA-transcription, DNA-templated-
GO:0006355NAS-regulation of transcription, DNA-templated11138001
GO:0008285IDA-negative regulation of cell proliferation15652505
GO:0009615IEP-response to virus20583921
GO:0031064IGI-negative regulation of histone deacetylation19276356
GO:0032088IDA-negative regulation of NF-kappaB transcription factor activity16652169
GO:0032689IDA-negative regulation of interferon-gamma production15466453
GO:0032689IMP-negative regulation of interferon-gamma production23169781
GO:0032693IDA-negative regulation of interleukin-10 production15466453
GO:0032700IMP-negative regulation of interleukin-17 production18368049
GO:0032703IDA-negative regulation of interleukin-2 production15466453
GO:0032703IMP-negative regulation of interleukin-2 production23169781
GO:0032713IDA-negative regulation of interleukin-4 production15466453
GO:0032714IEA-negative regulation of interleukin-5 production-
GO:0032715IEA-negative regulation of interleukin-6 production-
GO:0032720IEA-negative regulation of tumor necrosis factor production-
GO:0032753IEA-positive regulation of interleukin-4 production-
GO:0032792IDA-negative regulation of CREB transcription factor activity16652169
GO:0032831TAS-positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation18368049
GO:0032914IEA-positive regulation of transforming growth factor beta1 production-
GO:0033092IEA-positive regulation of immature T cell proliferation in thymus-
GO:0035066IMP-positive regulation of histone acetylation19276356
GO:0035067IEA-negative regulation of histone acetylation-
GO:0042036IDA-negative regulation of cytokine biosynthetic process11483607
GO:0042110IDA-T cell activation15466453
GO:0042130IDA-negative regulation of T cell proliferation15466453
GO:0042130IMP-negative regulation of T cell proliferation23169781
GO:0043029NAS-T cell homeostasis11483607
GO:0043433IDA-negative regulation of sequence-specific DNA binding transcription factor activity16873067
GO:0045077IEA-negative regulation of interferon-gamma biosynthetic process-
GO:0045085IMP-negative regulation of interleukin-2 biosynthetic process16873067
GO:0045892IDA-negative regulation of transcription, DNA-templated11483607
GO:0045892IMP-negative regulation of transcription, DNA-templated23169781
GO:0045893IDA-positive regulation of transcription, DNA-templated15466453
GO:0045893IMP-positive regulation of transcription, DNA-templated19276356
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter19276356
GO:0046007NAS-negative regulation of activated T cell proliferation11483607
GO:0048294IEA-negative regulation of isotype switching to IgE isotypes-
GO:0048302IEA-regulation of isotype switching to IgG isotypes-
GO:0050710IDA-negative regulation of cytokine secretion11483607
GO:0050777IDA-negative regulation of immune response15652505
GO:0050852IEA-T cell receptor signaling pathway-
GO:2000320IMP-negative regulation of T-helper 17 cell differentiation23169781
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FOXP3HDAC211917019276356 Co-localization
FOXP3HDAC210931619276356 Co-localization
FOXP3NFATC111917021490927 Affinity Capture-Luminescence
FOXP3NFATC111084521490927 Affinity Capture-Luminescence
FOXP3NFATC211917019564342 Co-localization
FOXP3NFATC211084619564342 Co-localization
FOXP3REL11189821490927 Affinity Capture-Luminescence
FOXP3REL11917021490927 Affinity Capture-Luminescence
FOXP3HDAC911508317360565 Affinity Capture-Western
FOXP3HDAC911917017360565 Affinity Capture-Western
FOXP3HDAC411510619276356 Co-localization
FOXP3HDAC411917019276356 Co-localization
FOXP3KAT511917017360565 Affinity Capture-Western
FOXP3KAT511577917360565 Affinity Capture-Western
HDAC7FOXP311961317360565 Affinity Capture-Western
HDAC7FOXP311917017360565 Affinity Capture-Western
IKZF4FOXP311917019696312 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IKZF4FOXP312214619696312 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891436
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061116-2'