AutismKB 2.0

Annotation Details for SHANK1


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Basic Information Top
Gene Symbol:SHANK1 ( SPANK-1,SSTRIP,synamon )
Gene Full Name: SH3 and multiple ankyrin repeat domains 1
Band: 19q13.33
Quick LinksEntrez ID:50944; OMIM: 604999; Uniprot ID:SHAN1_HUMAN; ENSEMBL ID: ENSG00000161681; HGNC ID: 15474
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622NAS-intracellular10551867
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886ISS-plasma membrane-
GO:0008328ISScolocalizes_withionotropic glutamate receptor complex-
GO:0014069ISS-postsynaptic density-
GO:0016020IDA-membrane10551867
GO:0017146ISScolocalizes_withNMDA selective glutamate receptor complex-
GO:0030054IEA-cell junction-
GO:0030425NAS-dendrite10551867
GO:0043005ISS-neuron projection-
GO:0043197ISS-dendritic spine-
GO:0045211ISS-postsynaptic membrane-
GO:0045211ISScolocalizes_withpostsynaptic membrane-
GO:0060076ISS-excitatory synapse-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding10551867
GO:0008022ISS-protein C-terminus binding-
GO:0017124ISS-SH3 domain binding-
GO:0030160ISS-GKAP/Homer scaffold activity-
GO:0031877ISS-somatostatin receptor binding-
GO:0032403ISS-protein complex binding-
GO:0035255ISS-ionotropic glutamate receptor binding-
GO:0042802ISS-identical protein binding-
GO:0071532ISS-ankyrin repeat binding-
GO:0097110ISS-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0006461ISS-protein complex assembly-
GO:0007016NAS-cytoskeletal anchoring at plasma membrane10551867
GO:0007616ISS-long-term memory-
GO:0008306ISS-associative learning-
GO:0030534IMP-adult behavior22503632
GO:0032232ISS-negative regulation of actin filament bundle assembly-
GO:0035176IMP-social behavior22503632
GO:0035418ISS-protein localization to synapse-
GO:0042048IEA-olfactory behavior-
GO:0046959IEA-habituation-
GO:0050885ISS-neuromuscular process controlling balance-
GO:0050894IMP-determination of affect22503632
GO:0060013IEA-righting reflex-
GO:0060074ISS-synapse maturation-
GO:0060997ISS-dendritic spine morphogenesis-
GO:0060999ISS-positive regulation of dendritic spine development-
GO:0071625IMP-vocalization behavior22503632
GO:2000311ISS-regulation of AMPA receptor activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SHANK1BAI211917110964907 Two-hybrid
SHANK1BAI210705210964907 Two-hybrid
SHANK1DNM211917111583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1DNM210812211583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1SPTAN111917111509555 Affinity Capture-Western; Reconstituted Complex
SHANK1SPTAN111258711509555 Affinity Capture-Western; Reconstituted Complex
SHANK1SSTR211917110551867 Affinity Capture-Western; Reconstituted Complex
SHANK1SSTR211263010551867 Affinity Capture-Western; Reconstituted Complex
SHANK1STAT111264920936779 Two-hybrid
SHANK1STAT111917120936779 Two-hybrid
SHANK1ARHGEF711439312626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1ARHGEF711917112626503 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1DLGAP111466012954649 Co-crystal Structure
SHANK1DLGAP111917112954649 Co-crystal Structure
SHANK1BAIAP211917112504591 Affinity Capture-Western; Far Western; Two-hybrid
SHANK1BAIAP211572112504591 Affinity Capture-Western; Far Western; Two-hybrid
SHANK1LPHN211917110964907 Two-hybrid
SHANK1LPHN211686810964907 Two-hybrid
SHARPINSHANK112360811178875 Affinity Capture-Western; Two-hybrid
SHARPINSHANK111917111178875 Affinity Capture-Western; Two-hybrid
SHANK1SHANK111917112954649 Co-crystal Structure
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:3613677
  • Data Attributes: HomoloGene calculated
No data