AutismKB 2.0

Annotation Details for LEF1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LEF1 ( DKFZp586H0919,FLJ46390,TCF1ALPHA )
Gene Full Name: lymphoid enhancer-binding factor 1
Band: 4q25
Quick LinksEntrez ID:51176; OMIM: 153245; Uniprot ID:LEF1_HUMAN; ENSEMBL ID: ENSG00000138795; HGNC ID: 6551
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus9308964
GO:0005634IDA-nucleus17063141
GO:0005654TAS-nucleoplasm-
GO:0005667IDA-transcription factor complex11751639
GO:0005737IDA-cytoplasm19402906
GO:0032993IDA-protein-DNA complex10825188
GO:1990907IPI-beta-catenin-TCF complex18936100
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding23001182
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001228IMP-transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding23001182
GO:0003677ISS-DNA binding-
GO:0003682IEA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding11751639
GO:0003705IBA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0005515IPI-protein binding9751710
GO:0008013IDA-beta-catenin binding9488439
GO:0008013IPI-beta-catenin binding10825188
GO:0008013TAS-beta-catenin binding16344550
GO:0008134IEA-transcription factor binding-
GO:0008301ISS-DNA binding, bending-
GO:0030284IDA-estrogen receptor activity18794125
GO:0030331IDA-estrogen receptor binding18794125
GO:0035326IDA-enhancer binding7657162
GO:0042393IPI-histone binding20363964
GO:0042826IPI-histone deacetylase binding18936100
GO:0043027IMP-cysteine-type endopeptidase inhibitor activity involved in apoptotic process20360943
GO:0043565IDA-sequence-specific DNA binding9308964
GO:0044212IDA-transcription regulatory region DNA binding16344550
GO:0044212ISS-transcription regulatory region DNA binding-
GO:0045295IPI-gamma-catenin binding14661054
GO:0070016IPI-armadillo repeat domain binding12408825
GO:0070742IPI-C2H2 zinc finger domain binding18445004
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001569IBA-branching involved in blood vessel morphogenesis-
GO:0001649IEP-osteoblast differentiation20128911
GO:0001755IBA-neural crest cell migration-
GO:0001756IBA-somitogenesis-
GO:0001837ISS-epithelial to mesenchymal transition-
GO:0002040IBA-sprouting angiogenesis-
GO:0006366IDA-transcription from RNA polymerase II promoter23001182
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0008284IDA-positive regulation of cell proliferation19351848
GO:0010628IDA-positive regulation of gene expression16344550
GO:0010718IMP-positive regulation of epithelial to mesenchymal transition20018240
GO:0016055IDA-Wnt signaling pathway10644691
GO:0016202IBA-regulation of striated muscle tissue development-
GO:0021542IBA-dentate gyrus development-
GO:0021854IBA-hypothalamus development-
GO:0021861IBA-forebrain radial glial cell differentiation-
GO:0021873IBA-forebrain neuroblast division-
GO:0021879IBA-forebrain neuron differentiation-
GO:0021943IBA-formation of radial glial scaffolds-
GO:0022407IBA-regulation of cell-cell adhesion-
GO:0030223IMP-neutrophil differentiation17063141
GO:0030307IMP-positive regulation of cell growth20360943
GO:0030326IBA-embryonic limb morphogenesis-
GO:0030335IMP-positive regulation of cell migration20018240
GO:0030509IBA-BMP signaling pathway-
GO:0030854IDA-positive regulation of granulocyte differentiation19620402
GO:0030854IMP-positive regulation of granulocyte differentiation23001182
GO:0030879IBA-mammary gland development-
GO:0032696IDA-negative regulation of interleukin-13 production18445004
GO:0032713IDA-negative regulation of interleukin-4 production18445004
GO:0032714IDA-negative regulation of interleukin-5 production18445004
GO:0033153IEA-T cell receptor V(D)J recombination-
GO:0042100IBA-B cell proliferation-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0043066IMP-negative regulation of apoptotic process20360943
GO:0043154IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process20360943
GO:0043392IDA-negative regulation of DNA binding18445004
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0043586IEA-tongue development-
GO:0043923IDA-positive regulation by host of viral transcription7657162
GO:0043966IMP-histone H3 acetylation20363964
GO:0043967IMP-histone H4 acetylation20363964
GO:0045063ISS-T-helper 1 cell differentiation-
GO:0045843IEA-negative regulation of striated muscle tissue development-
GO:0045892IDA-negative regulation of transcription, DNA-templated18794125
GO:0045892IMP-negative regulation of transcription, DNA-templated18579517
GO:0045893IDA-positive regulation of transcription, DNA-templated7657162
GO:0045893IMP-positive regulation of transcription, DNA-templated19351848
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter11751639
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter23001182
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046632IBA-alpha-beta T cell differentiation-
GO:0048069IBA-eye pigmentation-
GO:0048341IBA-paraxial mesoderm formation-
GO:0048747IBA-muscle fiber development-
GO:0050909IEA-sensory perception of taste-
GO:0060021ISS-palate development-
GO:0060033IEA-anatomical structure regression-
GO:0060070IDA-canonical Wnt signaling pathway20123964
GO:0060070IMP-canonical Wnt signaling pathway19576624
GO:0060325IBA-face morphogenesis-
GO:0060326IDA-cell chemotaxis19576624
GO:0060561IBA-apoptotic process involved in morphogenesis-
GO:0060710IBA-chorio-allantoic fusion-
GO:0061153IBA-trachea gland development-
GO:0071345IMP-cellular response to cytokine stimulus23001182
GO:0071353IDA-cellular response to interleukin-418579517
GO:0071864IMP-positive regulation of cell proliferation in bone marrow17063141
GO:0071866IMP-negative regulation of apoptotic process in bone marrow17063141
GO:0071895IBA-odontoblast differentiation-
GO:0071899IDA-negative regulation of estrogen receptor binding18794125
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway19402906
GO:1902262IEA-apoptotic process involved in blood vessel morphogenesis-
GO:1904837TAS-beta-catenin-TCF complex assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LEF1CTNNB11193548757136 10890911 10958684 11835406 12748295 15684397 16204248 16510874 16510875 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LEF1CTNNB11078808757136 10890911 10958684 11835406 12748295 15684397 16204248 16510874 16510875 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LEF1E2F110820117980157 Affinity Capture-Western
LEF1E2F111935417980157 Affinity Capture-Western
LEF1EP30010834712446687 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LEF1EP30011935412446687 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LEF1HDAC111935410958684 Affinity Capture-Western
LEF1HDAC110931510958684 Affinity Capture-Western
LEF1SMAD211935410890911 Affinity Capture-Western; Reconstituted Complex
LEF1SMAD211026210890911 Affinity Capture-Western; Reconstituted Complex
LEF1SMAD311935410890911 Affinity Capture-Western; Reconstituted Complex
LEF1SMAD311026310890911 Affinity Capture-Western; Reconstituted Complex
LEF1SMAD411935410890911 Reconstituted Complex
LEF1SMAD411026410890911 Reconstituted Complex
LEF1SMAD711935415684397 Affinity Capture-Western
LEF1SMAD711026715684397 Affinity Capture-Western
LEF1MITF11935412032083 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LEF1MITF11043212032083 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LEF1NOTCH111091311604490 Reconstituted Complex
LEF1NOTCH111935411604490 Reconstituted Complex
LEF1TLE11193549751710 Reconstituted Complex
LEF1TLE11129439751710 Reconstituted Complex
LEF1UBTF11319012748295 Affinity Capture-Western
LEF1UBTF11935412748295 Affinity Capture-Western
LEF1RUVBL11193549843967 Affinity Capture-Western
LEF1RUVBL11141669843967 Affinity Capture-Western
LEF1DAZAP211935419304756 Affinity Capture-Western
LEF1DAZAP211514319304756 Affinity Capture-Western
LEF1THOC41193549119228 Reconstituted Complex
LEF1THOC41154869119228 Reconstituted Complex
PIAS4LEF111935411731474 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS4LEF111962411731474 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NLKLEF111968512556497 Affinity Capture-Western
NLKLEF111935412556497 Affinity Capture-Western
DACT1LEF111948618936100 Affinity Capture-Western
DACT1LEF111935418936100 Affinity Capture-Western
ZBTB3LEF111935420211142 Two-hybrid
ZBTB3LEF112293320211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96770
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990714-26'