AutismKB 2.0

Annotation Details for TLR7


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Basic Information Top
Gene Symbol:TLR7 ( - )
Gene Full Name: toll-like receptor 7
Band: Xp22.2
Quick LinksEntrez ID:51284; OMIM: 300365; Uniprot ID:TLR7_HUMAN; ENSEMBL ID: ENSG00000196664; HGNC ID: 15631
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005737IDA-cytoplasm19740627
GO:0005764ISS-lysosome-
GO:0005768ISS-endosome-
GO:0005783ISS-endoplasmic reticulum-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane19740627
GO:0010008TAS-endosome membrane-
GO:0016021IEA-integral component of membrane-
GO:0032009ISS-early phagosome-
GO:0036020TAS-endolysosome membrane-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0003725IDA-double-stranded RNA binding16111635
GO:0003727IBA-single-stranded RNA binding-
GO:0003727ISS-single-stranded RNA binding-
GO:0004888IEA-transmembrane signaling receptor activity-
GO:0008144IEA-drug binding-
GO:0035197ISS-siRNA binding-
GO ID Evidence Qualifier GO_term References
GO:0001774IEA-microglial cell activation-
GO:0001932IEA-regulation of protein phosphorylation-
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002755IEA-MyD88-dependent toll-like receptor signaling pathway-
GO:0006954IEA-inflammatory response-
GO:0007252IDA-I-kappaB phosphorylation19740627
GO:0032722IDA-positive regulation of chemokine production19740627
GO:0032755IEA-positive regulation of interleukin-6 production-
GO:0032757IDA-positive regulation of interleukin-8 production19740627
GO:0034154IBA-toll-like receptor 7 signaling pathway-
GO:0034162TAS-toll-like receptor 9 signaling pathway-
GO:0042346IDA-positive regulation of NF-kappaB import into nucleus19740627
GO:0045078IDA-positive regulation of interferon-gamma biosynthetic process16286015
GO:0045087IEA-innate immune response-
GO:0045356IDA-positive regulation of interferon-alpha biosynthetic process16286015
GO:0045359IDA-positive regulation of interferon-beta biosynthetic process16286015
GO:0045416IMP-positive regulation of interleukin-8 biosynthetic process16188996
GO:0050729IC-positive regulation of inflammatory response19740627
GO:0051607IMP-defense response to virus16188996
GO:0071260IEP-cellular response to mechanical stimulus19593445
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2176882
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040219-11'