AutismKB 2.0

Annotation Details for TNFRSF12A


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Basic Information Top
Gene Symbol:TNFRSF12A ( CD266,FN14,TWEAKR )
Gene Full Name: tumor necrosis factor receptor superfamily, member 12A
Band: 16p13.3
Quick LinksEntrez ID:51330; OMIM: 605914; Uniprot ID:TNR12_HUMAN; ENSEMBL ID: ENSG00000006327; HGNC ID: 18152
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IEA-ruffle-
GO:0005886TAS-plasma membrane-
GO:0009986IEA-cell surface-
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11728344
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0006931IEA-substrate-dependent cell migration, cell attachment to substrate-
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0043065IDA-positive regulation of apoptotic process21525013
GO:0045765IEA-regulation of angiogenesis-
GO:0045773IEA-positive regulation of axon extension-
GO:0061041IDA-regulation of wound healing11728344
GO:0097191IEA-extrinsic apoptotic signaling pathway-
GO:2001238IMP-positive regulation of extrinsic apoptotic signaling pathway21525013
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TNFRSF12ATRAF111947811728344 Reconstituted Complex
TNFRSF12ATRAF111303711728344 Reconstituted Complex
TNFRSF12ATRAF211947811728344 Reconstituted Complex
TNFRSF12ATRAF211303811728344 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
TNFRSF12ARAC118182714573547 Fn14 interacts with Rac1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1351484
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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