AutismKB 2.0

Annotation Details for DACT1


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Basic Information Top
Gene Symbol:DACT1 ( DAPPER,DAPPER1,DPR1,FRODO,HDPR1,THYEX3 )
Gene Full Name: dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
Band: 14q23.1
Quick LinksEntrez ID:51339; OMIM: 607861; Uniprot ID:DACT1_HUMAN; ENSEMBL ID: ENSG00000165617; HGNC ID: 17748
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18936100
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm16446366
GO:0005829TAS-cytosol-
GO:0030054IEA-cell junction-
GO:0030877IDAcolocalizes_withbeta-catenin destruction complex22470507
GO:0045202IEA-synapse-
GO ID Evidence Qualifier GO_term References
GO:0001085IPI-RNA polymerase II transcription factor binding18936100
GO:0005080IBA-protein kinase C binding-
GO:0005080ISS-protein kinase C binding-
GO:0005515IPI-protein binding16446366
GO:0008013IDA-beta-catenin binding18936100
GO:0008013IPI-beta-catenin binding18936100
GO:0042826IPI-histone deacetylase binding18936100
GO:0051018IDA-protein kinase A binding21262972
GO:0070097IBA-delta-catenin binding-
GO:0070097ISS-delta-catenin binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter18936100
GO:0016055IEA-Wnt signaling pathway-
GO:0021915IMP-neural tube development22610794
GO:0030177IDA-positive regulation of Wnt signaling pathway21262972
GO:0030178IDA-negative regulation of Wnt signaling pathway16446366
GO:0030178IGI-negative regulation of Wnt signaling pathway16446366
GO:0030178IMP-negative regulation of Wnt signaling pathway18936100
GO:0031647IDA-regulation of protein stability21262972
GO:0032091IGI-negative regulation of protein binding18936100
GO:0032092IGI-positive regulation of protein binding18936100
GO:0035412IMP-regulation of catenin import into nucleus18936100
GO:0035413IMP-positive regulation of catenin import into nucleus15580286
GO:0045732IDA-positive regulation of protein catabolic process16446366
GO:0046329IDA-negative regulation of JNK cascade17197390
GO:0048619ISS-embryonic hindgut morphogenesis-
GO:0090090IGI-negative regulation of canonical Wnt signaling pathway18936100
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway22610794
GO:0090090TAS-negative regulation of canonical Wnt signaling pathway-
GO:1900107IDANOTregulation of nodal signaling pathway17197390
GO:1903364IDA-positive regulation of cellular protein catabolic process16446366
GO:1903364IMP-positive regulation of cellular protein catabolic process18936100
GO:1904864IDA-negative regulation of beta-catenin-TCF complex assembly18936100
GO:2000095IBA-regulation of Wnt signaling pathway, planar cell polarity pathway-
GO:2000095ISS-regulation of Wnt signaling pathway, planar cell polarity pathway-
GO:2000134IDA-negative regulation of G1/S transition of mitotic cell cycle18936100
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DACT1HDAC111948618936100 Affinity Capture-Western
DACT1HDAC110931518936100 Affinity Capture-Western
DACT1LEF111948618936100 Affinity Capture-Western
DACT1LEF111935418936100 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1891740
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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