AutismKB 2.0

Annotation Details for PDE3A


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Basic Information Top
Gene Symbol:PDE3A ( CGI-PDE )
Gene Full Name: phosphodiesterase 3A, cGMP-inhibited
Band: 12p12.2
Quick LinksEntrez ID:5139; OMIM: 123805; Uniprot ID:PDE3A_HUMAN; ENSEMBL ID: ENSG00000172572; HGNC ID: 8778
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0004115TAS-3',5'-cyclic-AMP phosphodiesterase activity-
GO:0004119IEA-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity-
GO:0030552IEA-cAMP binding-
GO:0046872IEA-metal ion binding-
GO:0047555TAS-3',5'-cyclic-GMP phosphodiesterase activity-
GO ID Evidence Qualifier GO_term References
GO:0001556IEA-oocyte maturation-
GO:0006198IDA-cAMP catabolic process17704206
GO:0006198IMP-cAMP catabolic process19252089
GO:0006629TAS-lipid metabolic process8921398
GO:0016101IEA-diterpenoid metabolic process-
GO:0019933IMP-cAMP-mediated signaling17704206
GO:0019934IMP-cGMP-mediated signaling17704206
GO:0040020IEA-regulation of meiotic nuclear division-
GO:0042493IEA-response to drug-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043116IMP-negative regulation of vascular permeability17704206
GO:0043117IMP-positive regulation of vascular permeability17704206
GO:0051591IEA-response to cAMP-
GO:0060282IEA-positive regulation of oocyte development-
GO:0071321IDA-cellular response to cGMP17704206
GO:0071560IEP-cellular response to transforming growth factor beta stimulus17704206
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1860764
  • Data Attributes: MGI curated and HomoloGene calculated
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018