AutismKB 2.0

Annotation Details for PDE1B


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Basic Information Top
Gene Symbol:PDE1B ( PDE1B1,PDES1B )
Gene Full Name: phosphodiesterase 1B, calmodulin-dependent
Band: 12q13.2
Quick LinksEntrez ID:5153; OMIM: 171891; Uniprot ID:PDE1B_HUMAN; ENSEMBL ID: ENSG00000123360; HGNC ID: 8775
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0043025IEA-neuronal cell body-
GO ID Evidence Qualifier GO_term References
GO:0004115TAS-3',5'-cyclic-AMP phosphodiesterase activity-
GO:0004117TAS-calmodulin-dependent cyclic-nucleotide phosphodiesterase activity9419816
GO:0005515IPI-protein binding21044950
GO:0005516IEA-calmodulin binding-
GO:0046872IEA-metal ion binding-
GO:0047555TAS-3',5'-cyclic-GMP phosphodiesterase activity-
GO:0048101IEA-calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity-
GO ID Evidence Qualifier GO_term References
GO:0001505IEA-regulation of neurotransmitter levels-
GO:0001975IEA-response to amphetamine-
GO:0006198IDA-cAMP catabolic process14687666
GO:0006915TAS-apoptotic process8855339
GO:0007165IEA-signal transduction-
GO:0007626IEA-locomotory behavior-
GO:0008542IEA-visual learning-
GO:0030224IEP-monocyte differentiation14687666
GO:0036006IDA-cellular response to macrophage colony-stimulating factor stimulus14687666
GO:0042053IEA-regulation of dopamine metabolic process-
GO:0042428IEA-serotonin metabolic process-
GO:0046069IDA-cGMP catabolic process14687666
GO:0097011IDA-cellular response to granulocyte macrophage colony-stimulating factor stimulus14687666
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97523
  • Data Attributes: MGI curated and HomoloGene calculated
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018