Gene Symbol:	SIRT6 ( SIR2L6 )
Gene Full Name:	sirtuin 6
Band:	19p13.3
Quick Links	Entrez ID:51548; OMIM: 606211; Uniprot ID:SIRT6_HUMAN; ENSEMBL ID: ENSG00000077463; HGNC ID: 14934
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	25819580
GO:0005634	ISS	-	nucleus	-
GO:0005654	IDA	-	nucleoplasm	16079181
GO:0005654	TAS	-	nucleoplasm	-
GO:0005724	IDA	-	nuclear telomeric heterochromatin	18337721
GO:0005730	IDA	NOT	nucleolus	16079181
GO:0005737	IEA	-	cytoplasm	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003682	IEA	-	chromatin binding	-
GO:0003714	IEA	-	transcription corepressor activity	-
GO:0003950	TAS	-	NAD+ ADP-ribosyltransferase activity	17456799
GO:0003956	ISS	-	NAD(P)+-protein-arginine ADP-ribosyltransferase activity	-
GO:0005515	IPI	-	protein binding	19135889
GO:0008270	ISS	-	zinc ion binding	-
GO:0017136	ISS	-	NAD-dependent histone deacetylase activity	-
GO:0034979	TAS	-	NAD-dependent protein deacetylase activity	-
GO:0046969	IDA	-	NAD-dependent histone deacetylase activity (H3-K9 specific)	18337721
GO:0070403	ISS	-	NAD+ binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003247	IEA	-	post-embryonic cardiac muscle cell growth involved in heart morphogenesis	-
GO:0006284	IEA	-	base-excision repair	-
GO:0006471	ISS	-	protein ADP-ribosylation	-
GO:0006471	TAS	-	protein ADP-ribosylation	17456799
GO:0008285	IEA	-	negative regulation of cell proliferation	-
GO:0010569	IDA	-	regulation of double-strand break repair via homologous recombination	19135889
GO:0031648	IEA	-	protein destabilization	-
GO:0031667	IEA	-	response to nutrient levels	-
GO:0031940	IMP	-	positive regulation of chromatin silencing at telomere	21847107
GO:0032206	IMP	-	positive regulation of telomere maintenance	23201774
GO:0042593	IEA	-	glucose homeostasis	-
GO:0045820	IEA	-	negative regulation of glycolytic process	-
GO:0045892	IEA	-	negative regulation of transcription, DNA-templated	-
GO:0046325	IEA	-	negative regulation of glucose import	-
GO:0048146	IEA	-	positive regulation of fibroblast proliferation	-
GO:0061647	IEA	-	histone H3-K9 modification	-
GO:1902732	IMP	-	positive regulation of chondrocyte proliferation	25819580
GO:1905549	IMP	-	positive regulation of telomeric heterochromatin assembly	21847107
GO:1905555	IMP	-	positive regulation blood vessel branching	23201774
GO:1905564	IMP	-	positive regulation of vascular endothelial cell proliferation	23201774
GO:1990619	IEA	-	histone H3-K9 deacetylation	-
GO:2000648	IEA	-	positive regulation of stem cell proliferation	-

Gene Symbol	Interactant	Interaction ID	References	Description
SIRT6	CHD3	119603	16169070	Two-hybrid
SIRT6	CHD3	107532	16169070	Two-hybrid
SIRT6	ELF5	119603	16189514	Two-hybrid
SIRT6	ELF5	108316	16189514	Two-hybrid
SIRT6	XRCC6	119603	20157594	Affinity Capture-MS; Affinity Capture-Western
SIRT6	XRCC6	108822	20157594	Affinity Capture-MS; Affinity Capture-Western
SIRT6	PRKDC	119603	20157594	Affinity Capture-MS; Affinity Capture-Western; Co-localization
SIRT6	PRKDC	111577	20157594	Affinity Capture-MS; Affinity Capture-Western; Co-localization
SIRT6	RELA	119603	19135889	Affinity Capture-Western; Reconstituted Complex
SIRT6	RELA	111902	19135889	Affinity Capture-Western; Reconstituted Complex
SIRT6	VIM	119603	16169070	Two-hybrid
SIRT6	VIM	113272	16169070	Two-hybrid
SIRT6	XRCC5	119603	20157594	Affinity Capture-MS; Affinity Capture-Western
SIRT6	XRCC5	113353	20157594	Affinity Capture-MS; Affinity Capture-Western
SIRT6	CCNDBP1	119603	17131381	Affinity Capture-Western; Reconstituted Complex
SIRT6	CCNDBP1	117117	17131381	Affinity Capture-Western; Reconstituted Complex

AutismKB 2.0

Annotation Details for SIRT6