AutismKB 2.0

Annotation Details for PDGFB


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Basic Information Top
Gene Symbol:PDGFB ( FLJ12858,PDGF2,SIS,SSV,c-sis )
Gene Full Name: platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Band: 22q13.1
Quick LinksEntrez ID:5155; OMIM: 190040; Uniprot ID:PDGFB_HUMAN; ENSEMBL ID: ENSG00000100311; HGNC ID: 8800
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005576NAS-extracellular region1661670
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005737ISS-cytoplasm-
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005796TAS-Golgi lumen-
GO:0009986IDA-cell surface291037
GO:0016323ISS-basolateral plasma membrane-
GO:0031012IDA-extracellular matrix23979707
GO:0031093TAS-platelet alpha granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005161IDA-platelet-derived growth factor receptor binding2439522
GO:0005161IPI-platelet-derived growth factor receptor binding2536956
GO:0005161NAS-platelet-derived growth factor receptor binding1661670
GO:0005515IPI-protein binding2536956
GO:0005518IDA-collagen binding8900172
GO:0008083IDA-growth factor activity12070119
GO:0016176IDA-superoxide-generating NADPH oxidase activator activity17942966
GO:0042056IDA-chemoattractant activity21245381
GO:0042802IPI-identical protein binding1396586
GO:0042803IDA-protein homodimerization activity2836953
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0046982IPI-protein heterodimerization activity7073684
GO:0048407IPI-platelet-derived growth factor binding7073684
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001892ISS-embryonic placenta development-
GO:0001938IDA-positive regulation of endothelial cell proliferation9685360
GO:0002548IDA-monocyte chemotaxis17991872
GO:0002576TAS-platelet degranulation-
GO:0003104ISS-positive regulation of glomerular filtration-
GO:0006468IDA-protein phosphorylation17942966
GO:0007179ISS-transforming growth factor beta receptor signaling pathway-
GO:0007507ISS-heart development-
GO:0008284IDA-positive regulation of cell proliferation2836953
GO:0009611IDA-response to wounding2538439
GO:0009611NAS-response to wounding1661670
GO:0010512IDA-negative regulation of phosphatidylinositol biosynthetic process2538439
GO:0010544IDA-negative regulation of platelet activation2538439
GO:0010628IDA-positive regulation of gene expression24008408
GO:0010629IDA-negative regulation of gene expression25089138
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling10734101
GO:0014911IDA-positive regulation of smooth muscle cell migration9409235
GO:0018105IDA-peptidyl-serine phosphorylation16530387
GO:0018108IDA-peptidyl-tyrosine phosphorylation10734101
GO:0030097IMPNOThemopoiesis11264163
GO:0030198TAS-extracellular matrix organization-
GO:0030335IDA-positive regulation of cell migration11788434
GO:0031954IDA-positive regulation of protein autophosphorylation12070119
GO:0032091IDA-negative regulation of protein binding22619279
GO:0032147IDA-activation of protein kinase activity16530387
GO:0032148IDA-activation of protein kinase B activity16530387
GO:0035655IDA-interleukin-18-mediated signaling pathway21321938
GO:0035793IDA-positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway19019919
GO:0038001ISS-paracrine signaling-
GO:0043406IDA-positive regulation of MAP kinase activity9685360
GO:0043410IMP-positive regulation of MAPK cascade11788434
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration9685360
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552IDA-positive regulation of phosphatidylinositol 3-kinase activity16530387
GO:0045737IDA-positive regulation of cyclin-dependent protein serine/threonine kinase activity16530387
GO:0045740IDA-positive regulation of DNA replication2439522
GO:0045840IDA-positive regulation of mitotic nuclear division10644978
GO:0045892IDA-negative regulation of transcription, DNA-templated16530387
GO:0045893IDA-positive regulation of transcription, DNA-templated16530387
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048008IDA-platelet-derived growth factor receptor signaling pathway2439522
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048146IDA-positive regulation of fibroblast proliferation2439522
GO:0048661IDA-positive regulation of smooth muscle cell proliferation12070119
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation21245381
GO:0050918IEA-positive chemotaxis-
GO:0050921IDA-positive regulation of chemotaxis9409235
GO:0051781IEA-positive regulation of cell division-
GO:0060326IDA-cell chemotaxis16014047
GO:0061098IDA-positive regulation of protein tyrosine kinase activity16530387
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade11788434
GO:0070528IMP-protein kinase C signaling24008408
GO:0071363IDA-cellular response to growth factor stimulus21245381
GO:0071506ISS-cellular response to mycophenolic acid-
GO:0072126IDA-positive regulation of glomerular mesangial cell proliferation11788434
GO:0072255ISS-metanephric glomerular mesangial cell development-
GO:0072593IMP-reactive oxygen species metabolic process17942966
GO:0090280IDA-positive regulation of calcium ion import19019919
GO:1900127IDA-positive regulation of hyaluronan biosynthetic process17324121
GO:1902894IDA-negative regulation of pri-miRNA transcription from RNA polymerase II promoter26493107
GO:1902895IDA-positive regulation of pri-miRNA transcription from RNA polymerase II promoter19088079
GO:1904707IDA-positive regulation of vascular smooth muscle cell proliferation19088079
GO:1904754IDA-positive regulation of vascular associated smooth muscle cell migration19088079
GO:1905064IDA-negative regulation of vascular smooth muscle cell differentiation19088079
GO:1905176IDA-positive regulation of vascular smooth muscle cell dedifferentiation19088079
GO:2000379IDA-positive regulation of reactive oxygen species metabolic process19019919
GO:2000573IDA-positive regulation of DNA biosynthetic process10644978
GO:2000587TAS-negative regulation of platelet-derived growth factor receptor-beta signaling pathway-
GO:2000591IDA-positive regulation of metanephric mesenchymal cell migration10734101
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PDGFBHSPG21095719692901 Reconstituted Complex
PDGFBHSPG21111819692901 Reconstituted Complex
PDGFBLRP111021511854294 Reconstituted Complex
PDGFBLRP111118111854294 Reconstituted Complex
SPARCPDGFB1125601311092 Reconstituted Complex
SPARCPDGFB1111811311092 Reconstituted Complex
PDGFBPDGFB1111811396586 Co-crystal Structure
PDGFRAPDGFB1111822544881 Reconstituted Complex
PDGFRAPDGFB1111812544881 Reconstituted Complex
PDAP1PDGFB1164618780057 Co-purification
PDAP1PDGFB1111818780057 Co-purification
THBS1PDGFB1129159334164 Reconstituted Complex
THBS1PDGFB1111819334164 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PDGFBrs130650, rs2040399, rs2285094 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97528
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050208-525'