AutismKB 2.0

Annotation Details for PDGFRA


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Basic Information Top
Gene Symbol:PDGFRA ( CD140A,MGC74795,PDGFR2,RHEPDGFRA )
Gene Full Name: platelet-derived growth factor receptor, alpha polypeptide
Band: 4q12
Quick LinksEntrez ID:5156; OMIM: 173490; Uniprot ID:PGFRA_HUMAN; ENSEMBL ID: ENSG00000134853; HGNC ID: 8803
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane2536956
GO:0005902IEA-microvillus-
GO:0009897IEA-external side of plasma membrane-
GO:0016020IDA-membrane19946888
GO:0030054IDA-cell junction-
GO:0031226IDA-intrinsic component of plasma membrane2554309
GO:0043234IDA-protein complex24190966
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity24190966
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity1646396
GO:0005018IDA-platelet-derived growth factor alpha-receptor activity2536956
GO:0005018IMP-platelet-derived growth factor alpha-receptor activity2554309
GO:0005021IDA-vascular endothelial growth factor-activated receptor activity17470632
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005161IPI-platelet-derived growth factor receptor binding2542288
GO:0005515IPI-protein binding7679113
GO:0005524IEA-ATP binding-
GO:0032403IEA-protein complex binding-
GO:0038085IPI-vascular endothelial growth factor binding17470632
GO:0042803IDA-protein homodimerization activity2542288
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0048407IDA-platelet-derived growth factor binding2554309
GO:0048407IPI-platelet-derived growth factor binding2536956
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001553ISS-luteinization-
GO:0001701IEA-in utero embryonic development-
GO:0001775TAS-cell activation10508235
GO:0002244IEA-hematopoietic progenitor cell differentiation-
GO:0007204IMP-positive regulation of cytosolic calcium ion concentration2554309
GO:0008210IEA-estrogen metabolic process-
GO:0008284IMP-positive regulation of cell proliferation2554309
GO:0010544IDA-negative regulation of platelet activation8188664
GO:0010863IMP-positive regulation of phospholipase C activity1646396
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068TAS-positive regulation of phosphatidylinositol 3-kinase signaling10734113
GO:0016032IEA-viral process-
GO:0018108IDA-peptidyl-tyrosine phosphorylation1646396
GO:0023019IEA-signal transduction involved in regulation of gene expression-
GO:0030198IEA-extracellular matrix organization-
GO:0030324IEA-lung development-
GO:0030325IEA-adrenal gland development-
GO:0030335IDA-positive regulation of cell migration17470632
GO:0030335IMP-positive regulation of cell migration1646396
GO:0030539IEA-male genitalia development-
GO:0033327IEA-Leydig cell differentiation-
GO:0034614IDA-cellular response to reactive oxygen species24190966
GO:0035790IMP-platelet-derived growth factor receptor-alpha signaling pathway2554309
GO:0038091IDA-positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway17470632
GO:0042060ISS-wound healing-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552IMP-positive regulation of phosphatidylinositol 3-kinase activity1646396
GO:0045740IDA-positive regulation of DNA replication10806482
GO:0046777IDA-protein autophosphorylation1646396
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048008IDA-platelet-derived growth factor receptor signaling pathway2536956
GO:0048015IMP-phosphatidylinositol-mediated signaling2554309
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048146IDA-positive regulation of fibroblast proliferation10806482
GO:0048557ISS-embryonic digestive tract morphogenesis-
GO:0048701ISS-embryonic cranial skeleton morphogenesis-
GO:0048704ISS-embryonic skeletal system morphogenesis-
GO:0050920IMP-regulation of chemotaxis2554309
GO:0055003ISS-cardiac myofibril assembly-
GO:0060021IEA-palate development-
GO:0060325IEA-face morphogenesis-
GO:0060326IMP-cell chemotaxis1646396
GO:0061298ISS-retina vasculature development in camera-type eye-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade10734113
GO:0070527IMP-platelet aggregation8188664
GO:0071230IEA-cellular response to amino acid stimulus-
GO:0072277ISS-metanephric glomerular capillary formation-
GO:2000249TAS-regulation of actin cytoskeleton reorganization10734113
GO:2000587TAS-negative regulation of platelet-derived growth factor receptor-beta signaling pathway-
GO:2000739IMP-regulation of mesenchymal stem cell differentiation21596750
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PDGFRACAV110730510066366 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PDGFRACAV111118210066366 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PDGFRACAV310730710066366 Reconstituted Complex
PDGFRACAV311118210066366 Reconstituted Complex
PDGFRACBL1073159234717 Affinity Capture-Western; Reconstituted Complex
PDGFRACBL1111829234717 Affinity Capture-Western; Reconstituted Complex
PDGFRACRK1111829546424 10733900 Affinity Capture-Western; Reconstituted Complex
PDGFRACRK1077889546424 10733900 Affinity Capture-Western; Reconstituted Complex
PDGFRACRKL1077899546424 Affinity Capture-Western
PDGFRACRKL1111829546424 Affinity Capture-Western
PDGFRAGRB21091428943348 Affinity Capture-Western
PDGFRAGRB21111828943348 Affinity Capture-Western
PDGFRAITGB310989611953315 Affinity Capture-Western
PDGFRAITGB311118211953315 Affinity Capture-Western
PDGFRAPDGFA1111822544881 Reconstituted Complex
PDGFRAPDGFA1111802544881 Reconstituted Complex
PDGFRAPDGFB1111822544881 Reconstituted Complex
PDGFRAPDGFB1111812544881 Reconstituted Complex
PDGFRBPDGFRA1111822542288 7523122 Affinity Capture-Western; Reconstituted Complex
PDGFRBPDGFRA1111852542288 7523122 Affinity Capture-Western; Reconstituted Complex
PDGFRAPDGFRA1111827523122 7535778 11046132 Affinity Capture-Western; Biochemical Activity; Far Western
PLCG1PDGFRA1111827535778 Affinity Capture-Western; Reconstituted Complex
PLCG1PDGFRA1113517535778 Affinity Capture-Western; Reconstituted Complex
SNX2PDGFRA1125269819414 Affinity Capture-Western
SNX2PDGFRA1111829819414 Affinity Capture-Western
SNX4PDGFRA1142629819414 Affinity Capture-Western
SNX4PDGFRA1111829819414 Affinity Capture-Western
SLC9A3R1PDGFRA11476911046132 Affinity Capture-Western; Far Western; Reconstituted Complex
SLC9A3R1PDGFRA11118211046132 Affinity Capture-Western; Far Western; Reconstituted Complex
SNX6PDGFRA11118211279102 Affinity Capture-Western
SNX6PDGFRA12185211279102 Affinity Capture-Western
PDGFCPDGFRA11118211297552 Affinity Capture-Western; Reconstituted Complex
PDGFCPDGFRA12103211297552 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PDGFRArs4864876, rs6554163, rs7656613, rs7677751, rs7686588 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97530
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-208'