AutismKB 2.0

Annotation Details for IL23A


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Basic Information Top
Gene Symbol:IL23A ( IL-23,IL-23A,IL23P19,MGC79388,P19,SGRF )
Gene Full Name: interleukin 23, alpha subunit p19
Band: 12q13.3
Quick LinksEntrez ID:51561; OMIM: 605580; Uniprot ID:IL23A_HUMAN; ENSEMBL ID: ENSG00000110944; HGNC ID: 15488
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0070743IDA-interleukin-23 complex11114383
GO ID Evidence Qualifier GO_term References
GO:0005125IEA-cytokine activity-
GO:0005515IPI-protein binding11114383
GO:0045519IDAcontributes_tointerleukin-23 receptor binding11114383
GO ID Evidence Qualifier GO_term References
GO:0001916ISS-positive regulation of T cell mediated cytotoxicity-
GO:0002230IDA-positive regulation of defense response to virus by host12421946
GO:0002230ISS-positive regulation of defense response to virus by host-
GO:0002827IDA-positive regulation of T-helper 1 type immune response15114670
GO:0002827ISS-positive regulation of T-helper 1 type immune response-
GO:0002827NAS-positive regulation of T-helper 1 type immune response20027291
GO:0002827TAS-positive regulation of T-helper 1 type immune response16751425
GO:0006954IEA-inflammatory response-
GO:0010536IDA-positive regulation of activation of Janus kinase activity12023369
GO:0032693IMP-negative regulation of interleukin-10 production16751425
GO:0032725IDA-positive regulation of granulocyte macrophage colony-stimulating factor production20027291
GO:0032729IDA-positive regulation of interferon-gamma production11114383
GO:0032729TAS-positive regulation of interferon-gamma production19088061
GO:0032733IDA-positive regulation of interleukin-10 production15265908
GO:0032733TAS-positive regulation of interleukin-10 production18675459
GO:0032735IDA-positive regulation of interleukin-12 production20027291
GO:0032740IDA-positive regulation of interleukin-17 production16482511
GO:0032760IMP-positive regulation of tumor necrosis factor production16751425
GO:0032816IC-positive regulation of natural killer cell activation20027291
GO:0032819IDA-positive regulation of natural killer cell proliferation19088061
GO:0034105IC-positive regulation of tissue remodeling16482511
GO:0042098IEA-T cell proliferation-
GO:0042102IDA-positive regulation of T cell proliferation12023369
GO:0042104IDA-positive regulation of activated T cell proliferation11114383
GO:0042346TAS-positive regulation of NF-kappaB import into nucleus20428758
GO:0042509IDA-regulation of tyrosine phosphorylation of STAT protein12023369
GO:0042531IDA-positive regulation of tyrosine phosphorylation of STAT protein12023369
GO:0043382ISS-positive regulation of memory T cell differentiation-
GO:0045087IEA-innate immune response-
GO:0045672IDA-positive regulation of osteoclast differentiation17888176
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048771IEA-tissue remodeling-
GO:0050729IC-positive regulation of inflammatory response16482511
GO:0050829IDA-defense response to Gram-negative bacterium15114670
GO:0051135IC-positive regulation of NK T cell activation20027291
GO:0051135IDA-positive regulation of NK T cell activation19088061
GO:0051142IDA-positive regulation of NK T cell proliferation19088061
GO:0051607IEA-defense response to virus-
GO:0090023IEA-positive regulation of neutrophil chemotaxis-
GO:2000318ISS-positive regulation of T-helper 17 type immune response-
GO:2000330IBA-positive regulation of T-helper 17 cell lineage commitment-
GO:2000330ISS-positive regulation of T-helper 17 cell lineage commitment-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IL23AIL12B11961111114383 Affinity Capture-Western
IL23AIL12B10980711114383 Affinity Capture-Western
IL23AIL12RB111961112023369 Reconstituted Complex
IL23AIL12RB110980812023369 Reconstituted Complex
IL23RIL23A11961112023369 Reconstituted Complex
IL23RIL23A12719912023369 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1932410
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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