AutismKB 2.0

Annotation Details for PDGFRB


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Basic Information Top
Gene Symbol:PDGFRB ( CD140B,JTK12,PDGFR,PDGFR1 )
Gene Full Name: platelet-derived growth factor receptor, beta polypeptide
Band: 5q32
Quick LinksEntrez ID:5159; OMIM: 173410; Uniprot ID:PGFRB_HUMAN; ENSEMBL ID: ENSG00000113721; HGNC ID: 8804
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0009986IEA-cell surface-
GO:0016020IDA-membrane16477012
GO:0016021IEA-integral component of membrane-
GO:0016324ISS-apical plasma membrane-
GO:0031226IDA-intrinsic component of plasma membrane2554309
GO:0031410IEA-cytoplasmic vesicle-
GO:0043202IEA-lysosomal lumen-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity1653029
GO:0004992TAS-platelet activating factor receptor activity2536956
GO:0005017TAS-platelet-derived growth factor-activated receptor activity2536956
GO:0005019IDA-platelet-derived growth factor beta-receptor activity1314164
GO:0005019IMP-platelet-derived growth factor beta-receptor activity2554309
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005102IPI-receptor binding10821867
GO:0005161IPI-platelet-derived growth factor receptor binding2542288
GO:0005515IPI-protein binding1314164
GO:0005524IEA-ATP binding-
GO:0019899IPI-enzyme binding26315405
GO:0019901IPI-protein kinase binding16479011
GO:0038085IPI-vascular endothelial growth factor binding17470632
GO:0043548IEA-phosphatidylinositol 3-kinase binding-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0048407IDA-platelet-derived growth factor binding2554309
GO:0048407IPI-platelet-derived growth factor binding2536956
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0006024IEA-glycosaminoglycan biosynthetic process-
GO:0007165IDA-signal transduction10821867
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007568IEA-aging-
GO:0008284IMP-positive regulation of cell proliferation2554309
GO:0008584IEA-male gonad development-
GO:0009636IEA-response to toxic substance-
GO:0010863IDA-positive regulation of phospholipase C activity1653029
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068ISS-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0014911IMP-positive regulation of smooth muscle cell migration21679854
GO:0014911ISS-positive regulation of smooth muscle cell migration-
GO:0016477IMP-cell migration2554309
GO:0018108IDA-peptidyl-tyrosine phosphorylation1653029
GO:0030335IDA-positive regulation of cell migration17470632
GO:0032355IEA-response to estradiol-
GO:0032516IDA-positive regulation of phosphoprotein phosphatase activity7691811
GO:0032526IEA-response to retinoic acid-
GO:0032956ISS-regulation of actin cytoskeleton organization-
GO:0032967IEA-positive regulation of collagen biosynthetic process-
GO:0034405IEA-response to fluid shear stress-
GO:0035025IEA-positive regulation of Rho protein signal transduction-
GO:0035441ISS-cell migration involved in vasculogenesis-
GO:0035789IEA-metanephric mesenchymal cell migration-
GO:0035791IMP-platelet-derived growth factor receptor-beta signaling pathway2554309
GO:0035793ISS-positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway-
GO:0035909ISS-aorta morphogenesis-
GO:0036120IEA-cellular response to platelet-derived growth factor stimulus-
GO:0038091IDA-positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway17470632
GO:0042060IEA-wound healing-
GO:0042542IEA-response to hydrogen peroxide-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043406ISS-positive regulation of MAP kinase activity-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552IDA-positive regulation of phosphatidylinositol 3-kinase activity1314164
GO:0043627IEA-response to estrogen-
GO:0045840ISS-positive regulation of mitotic nuclear division-
GO:0046488IMP-phosphatidylinositol metabolic process1653029
GO:0046777IDA-protein autophosphorylation1314164
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048008IDA-platelet-derived growth factor receptor signaling pathway1314164
GO:0048015IMP-phosphatidylinositol-mediated signaling2554309
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048146IEA-positive regulation of fibroblast proliferation-
GO:0048661IMP-positive regulation of smooth muscle cell proliferation21679854
GO:0048661ISS-positive regulation of smooth muscle cell proliferation-
GO:0048839IEA-inner ear development-
GO:0050921ISS-positive regulation of chemotaxis-
GO:0055003ISS-cardiac myofibril assembly-
GO:0055093IEA-response to hyperoxia-
GO:0060326IDA-cell chemotaxis2554309
GO:0060437IEA-lung growth-
GO:0060981ISS-cell migration involved in coronary angiogenesis-
GO:0061298ISS-retina vasculature development in camera-type eye-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade21679854
GO:0070374ISS-positive regulation of ERK1 and ERK2 cascade-
GO:0071670ISS-smooth muscle cell chemotaxis-
GO:0072075IEA-metanephric mesenchyme development-
GO:0072262ISS-metanephric glomerular mesangial cell proliferation involved in metanephros development-
GO:0072277ISS-metanephric glomerular capillary formation-
GO:0072278IEA-metanephric comma-shaped body morphogenesis-
GO:0072284IEA-metanephric S-shaped body morphogenesis-
GO:0090280ISS-positive regulation of calcium ion import-
GO:2000379ISS-positive regulation of reactive oxygen species metabolic process-
GO:2000491IEA-positive regulation of hepatic stellate cell activation-
GO:2000573ISS-positive regulation of DNA biosynthetic process-
GO:2000587TAS-negative regulation of platelet-derived growth factor receptor-beta signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PDGFRBADRBK110666512381737 Affinity Capture-Western
PDGFRBADRBK111118512381737 Affinity Capture-Western
PDGFRBCAV110730510066366 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PDGFRBCAV111118510066366 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PDGFRBCAV311118510066366 Reconstituted Complex
PDGFRBCAV310730710066366 Reconstituted Complex
PDGFRBCOPA1077099207175 Affinity Capture-Western
PDGFRBCOPA1111859207175 Affinity Capture-Western
PDGFRBCRK11118510733900 Affinity Capture-Western; Reconstituted Complex
PDGFRBCRK10778810733900 Affinity Capture-Western; Reconstituted Complex
PDGFRBS1PR111118512480944 Affinity Capture-Western
PDGFRBS1PR110822512480944 Affinity Capture-Western
PDGFRBEGFR1111859506992 Affinity Capture-Western
PDGFRBEGFR1082769506992 Affinity Capture-Western
PDGFRBGRB21091427935391 9362449 10026169 Affinity Capture-Western; Reconstituted Complex
PDGFRBGRB21111857935391 9362449 10026169 Affinity Capture-Western; Reconstituted Complex
PDGFRBGRB141111858647858 Reconstituted Complex
PDGFRBGRB141091458647858 Reconstituted Complex
PDGFRBITGB310989610964931 Affinity Capture-Western
PDGFRBITGB311118510964931 Affinity Capture-Western
PDGFRBNCK11107701333047 10026169 Affinity Capture-Western
PDGFRBNCK11111851333047 10026169 Affinity Capture-Western
PDGFRBPDGFRA1111822542288 7523122 Affinity Capture-Western; Reconstituted Complex
PDGFRBPDGFRA1111852542288 7523122 Affinity Capture-Western; Reconstituted Complex
RAF1PDGFRB1118312475255 Reconstituted Complex
RAF1PDGFRB1111852475255 Reconstituted Complex
PDGFRBPDGFRB1111857523122 11046132 Affinity Capture-Western; Far Western
PTPN11PDGFRB1111857691811 11266449 Reconstituted Complex; Two-hybrid
PTPN11PDGFRB1117457691811 11266449 Reconstituted Complex; Two-hybrid
SHC1PDGFRB1111858195171 Affinity Capture-Western
SHC1PDGFRB1123618195171 Affinity Capture-Western
PLCG1PDGFRB1111858443409 Affinity Capture-Western
PLCG1PDGFRB1113518443409 Affinity Capture-Western
NCK2PDGFRB1111859737977 10026169 11027258 Affinity Capture-Western; Reconstituted Complex
NCK2PDGFRB1140209737977 10026169 11027258 Affinity Capture-Western; Reconstituted Complex
SNX1PDGFRB1111859819414 Affinity Capture-Western
SNX1PDGFRB1125259819414 Affinity Capture-Western
SNX2PDGFRB1111859819414 Affinity Capture-Western
SNX2PDGFRB1125269819414 Affinity Capture-Western
SNX4PDGFRB1111859819414 Affinity Capture-Western
SNX4PDGFRB1142629819414 Affinity Capture-Western
PIK3R1PDGFRB11118510697503 Affinity Capture-Western
PIK3R1PDGFRB11131310697503 Affinity Capture-Western
RASA1PDGFRB11185610697503 11896619 Affinity Capture-Western
RASA1PDGFRB11118510697503 11896619 Affinity Capture-Western
VAV3PDGFRB11118510938113 Affinity Capture-Western
VAV3PDGFRB11571510938113 Affinity Capture-Western
VAV1PDGFRB11118510938113 Affinity Capture-Western
VAV1PDGFRB11325210938113 Affinity Capture-Western
VAV2PDGFRB11118510938113 Affinity Capture-Western
VAV2PDGFRB11325310938113 Affinity Capture-Western
SLC9A3R1PDGFRB11118511046132 Affinity Capture-Western; Far Western; Reconstituted Complex
SLC9A3R1PDGFRB11476911046132 Affinity Capture-Western; Far Western; Reconstituted Complex
EIF2AK2PDGFRB11118511350938 Affinity Capture-Western
EIF2AK2PDGFRB11159611350938 Affinity Capture-Western
SH3KBP1PDGFRB11118512177062 Affinity Capture-Western
SH3KBP1PDGFRB11902912177062 Affinity Capture-Western
UBCPDGFRB11118512381737 12717448 Affinity Capture-Western
UBCPDGFRB11316412381737 12717448 Affinity Capture-Western
KRTAP4-12PDGFRB11118516189514 Two-hybrid
KRTAP4-12PDGFRB12375616189514 Two-hybrid
PDCD6IPPDGFRB11118517082185 Affinity Capture-Western
PDCD6IPPDGFRB11533217082185 Affinity Capture-Western
SRCPDGFRB11118517158602 Affinity Capture-Western
SRCPDGFRB11259217158602 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PDGFRBrs2240780, rs3756311, rs3756312, rs3756314, rs6865659, rs740750, rs758588 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:97531
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030805-2'