AutismKB 2.0

Annotation Details for PDK4


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Basic Information Top
Gene Symbol:PDK4 ( FLJ40832 )
Gene Full Name: pyruvate dehydrogenase kinase, isozyme 4
Band: 7q21.3
Quick LinksEntrez ID:5166; OMIM: 602527; Uniprot ID:PDK4_HUMAN; ENSEMBL ID: ENSG00000004799; HGNC ID: 8812
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739TAS-mitochondrion8798399
GO:0005743IEA-mitochondrial inner membrane-
GO:0005759TAS-mitochondrial matrix-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity18658136
GO:0004740EXP-pyruvate dehydrogenase (acetyl-transferring) kinase activity11485553
GO:0004740ISS-pyruvate dehydrogenase (acetyl-transferring) kinase activity-
GO:0005524IDA-ATP binding18658136
GO ID Evidence Qualifier GO_term References
GO:0006006IEA-glucose metabolic process-
GO:0006468IEA-protein phosphorylation-
GO:0006885ISS-regulation of pH-
GO:0008286IMP-insulin receptor signaling pathway21852536
GO:0009267IDA-cellular response to starvation14966024
GO:0010510IMP-regulation of acetyl-CoA biosynthetic process from pyruvate21852536
GO:0010510TAS-regulation of acetyl-CoA biosynthetic process from pyruvate-
GO:0010565ISS-regulation of cellular ketone metabolic process-
GO:0010906IMP-regulation of glucose metabolic process21852536
GO:0042304IMP-regulation of fatty acid biosynthetic process21852536
GO:0042593ISS-glucose homeostasis-
GO:0042594ISS-response to starvation-
GO:0045124IEA-regulation of bone resorption-
GO:0046320ISS-regulation of fatty acid oxidation-
GO:0071398IMP-cellular response to fatty acid20715114
GO:0072593IMP-reactive oxygen species metabolic process21852536
GO:2000811IMP-negative regulation of anoikis21852536
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRIM63PDK411119218468620 Two-hybrid
TRIM63PDK412419518468620 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1351481
  • Data Attributes: MGI curated and HomoloGene calculated
No data