AutismKB 2.0

Annotation Details for ENPP1


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Basic Information Top
Gene Symbol:ENPP1 ( ARHR2,M6S1,NPP1,NPPS,PC-1,PCA1,PDNP1 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Band: 6q23.2
Quick LinksEntrez ID:5167; OMIM: 173335; Uniprot ID:ENPP1_HUMAN; ENSEMBL ID: ENSG00000197594; HGNC ID: 3356
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space11159191
GO:0005765IDA-lysosomal membrane17897319
GO:0005886IDA-plasma membrane10513816
GO:0005886TAS-plasma membrane-
GO:0005887ISS-integral component of plasma membrane-
GO:0009986IDA-cell surface10513816
GO:0016021ISS-integral component of membrane-
GO:0016323NAS-basolateral plasma membrane9553761
GO ID Evidence Qualifier GO_term References
GO:0003676IEA-nucleic acid binding-
GO:0004528IDA-phosphodiesterase I activity27467858
GO:0004528ISS-phosphodiesterase I activity-
GO:0004551IDA-nucleotide diphosphatase activity12746903
GO:0004551TAS-nucleotide diphosphatase activity-
GO:0005044IEA-scavenger receptor activity-
GO:0005158IDA-insulin receptor binding7830796
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding11289049
GO:0005524IDA-ATP binding7830796
GO:0008270ISS-zinc ion binding-
GO:0030247IEA-polysaccharide binding-
GO:0035529IEA-NADH pyrophosphatase activity-
GO:0042803IDA-protein homodimerization activity7830796
GO:0047429IDA-nucleoside-triphosphate diphosphatase activity7830796
GO:0050656IC-3'-phosphoadenosine 5'-phosphosulfate binding7830796
GO ID Evidence Qualifier GO_term References
GO:0006091IDA-generation of precursor metabolites and energy12746903
GO:0006771TAS-riboflavin metabolic process-
GO:0006796IDA-phosphate-containing compound metabolic process10513816
GO:0006898IEA-receptor-mediated endocytosis-
GO:0006955IEA-immune response-
GO:0009143IDA-nucleoside triphosphate catabolic process10513816
GO:0030308IDA-negative regulation of cell growth17849011
GO:0030500IC-regulation of bone mineralization10513816
GO:0030505IDA-inorganic diphosphate transport10513816
GO:0030643IDA-cellular phosphate ion homeostasis11159191
GO:0030730IDA-sequestering of triglyceride17849011
GO:0031214IEA-biomineral tissue development-
GO:0031953IDA-negative regulation of protein autophosphorylation11289049
GO:0032869IDA-cellular response to insulin stimulus7830796
GO:0045599IDA-negative regulation of fat cell differentiation17849011
GO:0045719IDA-negative regulation of glycogen biosynthetic process11289049
GO:0046325IDA-negative regulation of glucose import17849011
GO:0046627IDA-negative regulation of insulin receptor signaling pathway7830796
GO:0050427IDA-3'-phosphoadenosine 5'-phosphosulfate metabolic process7830796
GO:0090305IEA-nucleic acid phosphodiester bond hydrolysis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ENPP1INSR11119310615944 Affinity Capture-Western; Reconstituted Complex
ENPP1INSR10985410615944 Affinity Capture-Western; Reconstituted Complex
SQSTM1ENPP111439720562859 Affinity Capture-MS
SQSTM1ENPP111119320562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ENPP1rs1044498 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:97370
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040724-172'