AutismKB 2.0

Annotation Details for PDPK1


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Basic Information Top
Gene Symbol:PDPK1 ( MGC20087,MGC35290,PDK1,PRO0461 )
Gene Full Name: 3-phosphoinositide dependent protein kinase-1
Band: 16p13.3
Quick LinksEntrez ID:5170; OMIM: 605213; Uniprot ID:PDPK1_HUMAN; ENSEMBL ID: ENSG00000140992; HGNC ID: 8816
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IBA-intracellular-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm9637919
GO:0005737IEA-cytoplasm-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane9637919
GO:0005886TAS-plasma membrane-
GO:0005925IEA-focal adhesion-
GO:0014069IEA-postsynaptic density-
GO:0016020IEA-membrane-
GO:0031410IEA-cytoplasmic vesicle-
GO:0042995IDA-cell projection22454520
GO:0043204IEA-perikaryon-
GO ID Evidence Qualifier GO_term References
GO:0004674EXP-protein serine/threonine kinase activity9445477
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004674IDA-protein serine/threonine kinase activity9368760
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004676IDA-3-phosphoinositide-dependent protein kinase activity9368760
GO:0005158IEA-insulin receptor binding-
GO:0005515IPI-protein binding11438723
GO:0005524IEA-ATP binding-
GO:0016004IMP-phospholipase activator activity22454520
GO:0016301TAS-kinase activity-
GO:0019901IEA-protein kinase binding-
GO:0043274IPI-phospholipase binding22454520
GO ID Evidence Qualifier GO_term References
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0003323IEA-type B pancreatic cell development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IEA-regulation of transcription, DNA-templated-
GO:0006468IDA-protein phosphorylation14585963
GO:0006469IDA-negative regulation of protein kinase activity9373175
GO:0006972IEA-hyperosmotic response-
GO:0007173IMP-epidermal growth factor receptor signaling pathway22454520
GO:0010518IMP-positive regulation of phospholipase activity22454520
GO:0010594IEA-regulation of endothelial cell migration-
GO:0010667IEA-negative regulation of cardiac muscle cell apoptotic process-
GO:0016477IMP-cell migration22454520
GO:0018105IBA-peptidyl-serine phosphorylation-
GO:0018107IDA-peptidyl-threonine phosphorylation9368760
GO:0019722IMP-calcium-mediated signaling22454520
GO:0030036TAS-actin cytoskeleton organization10792047
GO:0030168TAS-platelet activation-
GO:0030512IDA-negative regulation of transforming growth factor beta receptor signaling pathway17327236
GO:0031295TAS-T cell costimulation-
GO:0032148IDA-activation of protein kinase B activity9368760
GO:0032869IMP-cellular response to insulin stimulus10567711
GO:0034122IEA-negative regulation of toll-like receptor signaling pathway-
GO:0035556IBA-intracellular signal transduction-
GO:0035556IDA-intracellular signal transduction14749367
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043122IMP-regulation of I-kappaB kinase/NF-kappaB signaling16207722
GO:0043304IEA-regulation of mast cell degranulation-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0046777TAS-protein autophosphorylation15209375
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048041IEA-focal adhesion assembly-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051281IDA-positive regulation of release of sequestered calcium ion into cytosol22454520
GO:0071364IMP-cellular response to epidermal growth factor stimulus22454520
GO:0090004IMP-positive regulation of establishment of protein localization to plasma membrane10567711
GO:0097191IMP-extrinsic apoptotic signaling pathway16207722
GO:1990416IEA-cellular response to brain-derived neurotrophic factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PDPK1AKT111119611313365 11825911 Affinity Capture-Western
PDPK1AKT110671011313365 11825911 Affinity Capture-Western
PDPK1ILK10982411313365 Affinity Capture-Western
PDPK1ILK11119611313365 Affinity Capture-Western
PDPK1PA2G411107520562859 Affinity Capture-MS
PDPK1PA2G411119620562859 Affinity Capture-MS
PRKCZPDPK11115769748166 10357815 10764742 11781095 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
PRKCZPDPK11111969748166 10357815 10764742 11781095 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAPK8PDPK111158510357815 Reconstituted Complex
MAPK8PDPK111119610357815 Reconstituted Complex
SGK1PDPK111234410357815 12387817 Reconstituted Complex
SGK1PDPK111119610357815 12387817 Reconstituted Complex
PRKACAPDPK111119610698939 Reconstituted Complex; Two-hybrid
PRKACAPDPK111155310698939 Reconstituted Complex; Two-hybrid
PKN2PDPK111119610764742 11781095 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PKN2PDPK111157210764742 11781095 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKCIPDPK111119610764742 Reconstituted Complex; Two-hybrid
PRKCIPDPK111157010764742 Reconstituted Complex; Two-hybrid
PKN1PDPK111119610764742 Reconstituted Complex; Two-hybrid
PKN1PDPK111157110764742 Reconstituted Complex; Two-hybrid
RPS6KA3PDPK111211110856237 Affinity Capture-Western
RPS6KA3PDPK111119610856237 Affinity Capture-Western
PDPK1PDPK111119610856237 Biochemical Activity
PRKCBPDPK111119611376011 Reconstituted Complex
PRKCBPDPK111156511376011 Reconstituted Complex
PRKCDPDPK111119611781095 Affinity Capture-Western; Two-hybrid
PRKCDPDPK111156611781095 Affinity Capture-Western; Two-hybrid
YWHAQPDPK111616812177059 Affinity Capture-Western
YWHAQPDPK111119612177059 Affinity Capture-Western
YWHAHPDPK111336512177059 Affinity Capture-Western; Reconstituted Complex
YWHAHPDPK111119612177059 Affinity Capture-Western; Reconstituted Complex
SLC9A3R2PDPK111475412387817 Affinity Capture-Western
SLC9A3R2PDPK111119612387817 Affinity Capture-Western
PRKCQPDPK111119615802604 Affinity Capture-Western
PRKCQPDPK111157415802604 Affinity Capture-Western
CARD11PDPK111119615802604 Affinity Capture-Western
CARD11PDPK112407315802604 Affinity Capture-Western
PRSS23PDPK111627916169070 Two-hybrid
PRSS23PDPK111119616169070 Two-hybrid
G3BP1PDPK111544820562859 Affinity Capture-MS
G3BP1PDPK111119620562859 Affinity Capture-MS
TBL2PDPK111776220562859 Affinity Capture-MS
TBL2PDPK111119620562859 Affinity Capture-MS
SND1PDPK111797420562859 Affinity Capture-MS
SND1PDPK111119620562859 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
PRKCZPDPK126238712223477 An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCZ (PKC-zeta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCZ from an unspecified species.
PRKCEPDPK126239112223477 An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species.
PRKCHPDPK126238912223477 An unspecified isoform of PDPK1 (PDK1) interacts with and phosphorylates PRKCH (PKC-eta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCH from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338068
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1820'