AutismKB 2.0

Annotation Details for RAPGEF6


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Basic Information Top
Gene Symbol:RAPGEF6 ( DKFZp667N084,DKFZp686I15116,KIA001LB,PDZ-GEF2,PDZGEF2,RA-GEF-2,RAGEF2 )
Gene Full Name: Rap guanine nucleotide exchange factor (GEF) 6
Band: 5q31.1
Quick LinksEntrez ID:51735; OMIM: 610499; Uniprot ID:RPGF6_HUMAN; ENSEMBL ID: ENSG00000158987,ENSG00000217128; HGNC ID: 20655
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005813IDA-centrosome-
GO:0005829IDA-cytosol22797597
GO:0005886IDA-plasma membrane11524421
GO:0016324IDA-apical plasma membrane22797597
GO:0030139IDA-endocytic vesicle22797597
GO ID Evidence Qualifier GO_term References
GO:0005085IDA-guanyl-nucleotide exchange factor activity11524421
GO:0005515IPI-protein binding12095257
GO:0017016IDA-Ras GTPase binding11524421
GO:0030742IDA-GTP-dependent protein binding11524421
GO:0070300IDA-phosphatidic acid binding22797597
GO ID Evidence Qualifier GO_term References
GO:0007265NAS-Ras protein signal transduction11524421
GO:0030033IGI-microvillus assembly22797597
GO:0043087NAS-regulation of GTPase activity11524421
GO:0043547IMP-positive regulation of GTPase activity22797597
GO:0072659IMP-protein localization to plasma membrane22797597
GO:0090557IMPNOTestablishment of endothelial intestinal barrier23885123
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RAPGEF6NEDD411081116055720 Affinity Capture-MS
RAPGEF6NEDD411970516055720 Affinity Capture-MS
RAPGEF6RAP1A11184111524421 Biochemical Activity
RAPGEF6RAP1A11970511524421 Biochemical Activity
RAPGEF6RAP2A11184611524421 Biochemical Activity
RAPGEF6RAP2A11970511524421 Biochemical Activity
RAPGEF6MRAS11648611524421 Reconstituted Complex
RAPGEF6MRAS11970511524421 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
RAPGEF6rs1291602, rs1422871, rs244739, rs31251, rs4996522, rs6873582, rs739952 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:2384761
  • Data Attributes: MGI curated and HomoloGene calculated
No data