AutismKB 2.0

Annotation Details for GHRL


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Basic Information Top
Gene Symbol:GHRL ( MTLRP )
Gene Full Name: ghrelin/obestatin prepropeptide
Band: 3p25.3
Quick LinksEntrez ID:51738; OMIM: 605353; Uniprot ID:GHRL_HUMAN; ENSEMBL ID: ENSG00000157017; HGNC ID: 18129
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region17392603
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space15039149
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0030424IDA-axon17113048
GO:0034774TAS-secretory granule lumen-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0001664ISS-G-protein coupled receptor binding10604470
GO:0005515IPI-protein binding25416956
GO:0016608ISS-growth hormone-releasing hormone activity10604470
GO:0016608TAS-growth hormone-releasing hormone activity16511605
GO:0030296IMP-protein tyrosine kinase activator activity15350694
GO:0031768ISS-ghrelin receptor binding-
GO:0031768TAS-ghrelin receptor binding16511605
GO ID Evidence Qualifier GO_term References
GO:0000187IMP-activation of MAPK activity15350694
GO:0001696IBA-gastric acid secretion-
GO:0001937IDA-negative regulation of endothelial cell proliferation15572208
GO:0006006NAS-glucose metabolic process17392603
GO:0007186ISS-G-protein coupled receptor signaling pathway10604470
GO:0007186TAS-G-protein coupled receptor signaling pathway16511605
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0008154IDA-actin polymerization or depolymerization15232612
GO:0008343ISS-adult feeding behavior-
GO:0009725IDA-response to hormone15232612
GO:0009755TAS-hormone-mediated signaling pathway16511605
GO:0016358IDA-dendrite development16491079
GO:0016525NAS-negative regulation of angiogenesis15572208
GO:0030252TAS-growth hormone secretion16511605
GO:0032024ISS-positive regulation of insulin secretion-
GO:0032095IBA-regulation of response to food-
GO:0032100ISS-positive regulation of appetite-
GO:0032691IDA-negative regulation of interleukin-1 beta production15232612
GO:0040013IEA-negative regulation of locomotion-
GO:0040018IC-positive regulation of multicellular organism growth16511605
GO:0042127IDA-regulation of cell proliferation15564328
GO:0042322IDA-negative regulation of circadian sleep/wake cycle, REM sleep18329818
GO:0042536IDA-negative regulation of tumor necrosis factor biosynthetic process15232612
GO:0043066IDA-negative regulation of apoptotic process15158140
GO:0043400NAS-cortisol secretion17201814
GO:0043627IDA-response to estrogen15292338
GO:0045409IDA-negative regulation of interleukin-6 biosynthetic process15232612
GO:0046010IDA-positive regulation of circadian sleep/wake cycle, non-REM sleep18329818
GO:0046676IEA-negative regulation of insulin secretion-
GO:0046697IDA-decidualization17494105
GO:0050728IDA-negative regulation of inflammatory response15232612
GO:0051216NAS-cartilage development15576457
GO:0051461IDA-positive regulation of corticotropin secretion12566947
GO:0051464IDA-positive regulation of cortisol secretion12566947
GO:0051965IDA-positive regulation of synapse assembly16491079
GO:0060079IEA-excitatory postsynaptic potential-
GO:0060124IDA-positive regulation of growth hormone secretion12566947
GO:0060399IC-positive regulation of growth hormone receptor signaling pathway12566947
GO:0061098IEA-positive regulation of protein tyrosine kinase activity-
GO:2000506IEA-negative regulation of energy homeostasis-
GO:2000507IEA-positive regulation of energy homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GHRLMLNR11970612606621 Reconstituted Complex
GHRLMLNR10912012606621 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1930008
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070622-2'