AutismKB 2.0

Annotation Details for WWOX


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Basic Information Top
Gene Symbol:WWOX ( D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1 )
Gene Full Name: WW domain containing oxidoreductase
Band: 16q23.1-q23.2
Quick LinksEntrez ID:51741; OMIM: 605131; Uniprot ID:WWOX_HUMAN; ENSEMBL ID: ENSG00000186153; HGNC ID: 12799
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus19366691
GO:0005737IDA-cytoplasm19465938
GO:0005737TAS-cytoplasm10786676
GO:0005739ISS-mitochondrion-
GO:0005794IDA-Golgi apparatus15064722
GO:0005829IDA-cytosol19366691
GO:0005829TAS-cytosol-
GO:0005886IDAcolocalizes_withplasma membrane19366691
GO:0005902IDAcolocalizes_withmicrovillus19366691
GO:0090575ISS-RNA polymerase II transcription factor complex19366691
GO ID Evidence Qualifier GO_term References
GO:0001105ISScontributes_toRNA polymerase II transcription coactivator activity19366691
GO:0005515IPI-protein binding15064722
GO:0016491NAS-oxidoreductase activity10861292
GO:0016491TAS-oxidoreductase activity10786676
GO:0019899IPI-enzyme binding19366691
GO:0046983TAS-protein dimerization activity10786676
GO:0048037TAS-cofactor binding10786676
GO:0050662TAS-coenzyme binding10786676
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001649IEA-osteoblast differentiation-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0008202TAS-steroid metabolic process10786676
GO:0016055IEA-Wnt signaling pathway-
GO:0030178IDA-negative regulation of Wnt signaling pathway19465938
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048705ISS-skeletal system morphogenesis-
GO:0055114TAS-oxidation-reduction process10786676
GO:0071560IDA-cellular response to transforming growth factor beta stimulus19366691
GO:0072332IEA-intrinsic apoptotic signaling pathway by p53 class mediator-
GO:0097191IEA-extrinsic apoptotic signaling pathway-
GO:2001238ISS-positive regulation of extrinsic apoptotic signaling pathway-
GO:2001241IEA-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WWOXHNRNPK10943116055720 Affinity Capture-MS
WWOXHNRNPK11970716055720 Affinity Capture-MS
WWOXPOLR2A11142616055720 Affinity Capture-MS
WWOXPOLR2A11970716055720 Affinity Capture-MS
WWOXPOLR2B11142716055720 Affinity Capture-MS
WWOXPOLR2B11970716055720 Affinity Capture-MS
WWOXSFPQ11231916055720 Affinity Capture-MS
WWOXSFPQ11970716055720 Affinity Capture-MS
WWOXSMARCC111248316055720 Affinity Capture-MS
WWOXSMARCC111970716055720 Affinity Capture-MS
WWOXTP5311301011058590 Affinity Capture-Western; Two-hybrid
WWOXTP5311970711058590 Affinity Capture-Western; Two-hybrid
WWOXSYMPK11383316055720 Affinity Capture-MS
WWOXSYMPK11970716055720 Affinity Capture-MS
WWOXSF3A111558016055720 Affinity Capture-MS
WWOXSF3A111970716055720 Affinity Capture-MS
WWOXTCERG111612016055720 Affinity Capture-MS
WWOXTCERG111970716055720 Affinity Capture-MS
WWOXNUDT2111623716055720 Affinity Capture-MS
WWOXNUDT2111970716055720 Affinity Capture-MS
WWOXCPSF611623816055720 Affinity Capture-MS; Reconstituted Complex
WWOXCPSF611970716055720 Affinity Capture-MS; Reconstituted Complex
WWOXRPRD211685216055720 Affinity Capture-MS
WWOXRPRD211970716055720 Affinity Capture-MS
WWOXSF3B311970716055720 Affinity Capture-MS
WWOXSF3B311701616055720 Affinity Capture-MS
WWOXSF3B111970716055720 Affinity Capture-MS
WWOXSF3B111701716055720 Affinity Capture-MS
WWOXWBP211710216055720 Affinity Capture-MS
WWOXWBP211970716055720 Affinity Capture-MS
WWOXPABPC111793916055720 Affinity Capture-MS
WWOXPABPC111970716055720 Affinity Capture-MS
WWOXCPSF111894616055720 Affinity Capture-MS
WWOXCPSF111970716055720 Affinity Capture-MS
WWOXCPSF311968016055720 Affinity Capture-MS
WWOXCPSF311970716055720 Affinity Capture-MS
WIPF2WWOX11970716055720 Affinity Capture-MS
WIPF2WWOX12704316055720 Affinity Capture-MS
CPSF2WWOX11982616055720 Affinity Capture-MS
CPSF2WWOX11970716055720 Affinity Capture-MS
WDR33WWOX12062016055720 Affinity Capture-MS
WDR33WWOX11970716055720 Affinity Capture-MS
CPSF7WWOX11970716055720 Affinity Capture-MS
CPSF7WWOX12295716055720 Affinity Capture-MS
FIP1L1WWOX11970716055720 Affinity Capture-MS
FIP1L1WWOX12354516055720 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1931237
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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