AutismKB 2.0

Annotation Details for INPP5K


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Basic Information Top
Gene Symbol:INPP5K ( PPS,SKIP )
Gene Full Name: inositol polyphosphate-5-phosphatase K
Band: 17p13.3
Quick LinksEntrez ID:51763; OMIM: 607875; Uniprot ID:INP5K_HUMAN; ENSEMBL ID: ENSG00000132376; HGNC ID: 33882
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726IDA-ruffle12536145
GO:0005634IDA-nucleus18774950
GO:0005737ISS-cytoplasm-
GO:0005783IDA-endoplasmic reticulum12536145
GO:0005802IDA-trans-Golgi network12556481
GO:0005829IDA-cytosol10753883
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12556481
GO:0016020IDA-membrane12536145
GO:0032587IDA-ruffle membrane12556481
GO:0043005IDA-neuron projection10753883
GO:0048471IDA-perinuclear region of cytoplasm18774950
GO ID Evidence Qualifier GO_term References
GO:0004439TAS-phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity-
GO:0004445IEA-inositol-polyphosphate 5-phosphatase activity-
GO:0005000ISS-vasopressin receptor activity-
GO:0005515IPI-protein binding16002321
GO:0016312IDA-inositol bisphosphate phosphatase activity10753883
GO:0034485IDA-phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity21712384
GO:0034485TAS-phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity-
GO:0034594IDA-phosphatidylinositol trisphosphate phosphatase activity12556481
GO:0034595IMP-phosphatidylinositol phosphate 5-phosphatase activity18774950
GO:0042577NAS-lipid phosphatase activity10753883
GO:0046030IDA-inositol trisphosphate phosphatase activity10753883
GO:0052658IEA-inositol-1,4,5-trisphosphate 5-phosphatase activity-
GO:0052659IEA-inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity-
GO ID Evidence Qualifier GO_term References
GO:0001701IEA-in utero embryonic development-
GO:0001933ISS-negative regulation of protein phosphorylation-
GO:0005979ISS-regulation of glycogen biosynthetic process-
GO:0006469IDA-negative regulation of protein kinase activity12556481
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0007186ISS-G-protein coupled receptor signaling pathway-
GO:0010801IDA-negative regulation of peptidyl-threonine phosphorylation12556481
GO:0010829IDA-negative regulation of glucose transport12556481
GO:0016311IDA-dephosphorylation21712384
GO:0016311IMP-dephosphorylation18774950
GO:0030036NAS-actin cytoskeleton organization10753883
GO:0032869IDA-cellular response to insulin stimulus12556481
GO:0032870ISS-cellular response to hormone stimulus-
GO:0033137IDA-negative regulation of peptidyl-serine phosphorylation12556481
GO:0035305ISS-negative regulation of dephosphorylation-
GO:0035810ISS-positive regulation of urine volume-
GO:0042593ISS-glucose homeostasis-
GO:0043407IDA-negative regulation of MAP kinase activity12556481
GO:0043922IDA-negative regulation by host of viral transcription18774950
GO:0045719IDA-negative regulation of glycogen biosynthetic process12556481
GO:0045869IDA-negative regulation of single stranded viral RNA replication via double stranded DNA intermediate18774950
GO:0045892ISS-negative regulation of transcription, DNA-templated-
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0046627IDA-negative regulation of insulin receptor signaling pathway12556481
GO:0046855IDA-inositol phosphate dephosphorylation12536145
GO:0046856IDA-phosphatidylinositol dephosphorylation12536145
GO:0051497IDA-negative regulation of stress fiber assembly12556481
GO:0051898IDA-negative regulation of protein kinase B signaling12556481
GO:0051926IDA-negative regulation of calcium ion transport12556481
GO:0071320ISS-cellular response to cAMP-
GO:0071356IDA-cellular response to tumor necrosis factor21712384
GO:0071364IDA-cellular response to epidermal growth factor stimulus21712384
GO:0072661ISS-protein targeting to plasma membrane-
GO:0090315IDA-negative regulation of protein targeting to membrane12556481
GO:0097178IDA-ruffle assembly12556481
GO:2000466ISS-negative regulation of glycogen (starch) synthase activity-
GO:2001153ISS-positive regulation of renal water transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
INPP5KNCOR211972011509665 Two-hybrid
INPP5KNCOR211497411509665 Two-hybrid
INPP5KARL6IP111972016189514 Two-hybrid
INPP5KARL6IP111681216189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1194899
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100408-3'