AutismKB 2.0

Annotation Details for PHB


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Basic Information Top
Gene Symbol:PHB ( PHB1 )
Gene Full Name: prohibitin
Band: 17q21.33
Quick LinksEntrez ID:5245; OMIM: 176705; Uniprot ID:PHB_HUMAN; ENSEMBL ID: ENSG00000167085; HGNC ID: 8912
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16964284
GO:0005634TAS-nucleus16130169
GO:0005654IDA-nucleoplasm12466959
GO:0005737IDA-cytoplasm16964284
GO:0005739IDA-mitochondrion20833797
GO:0005743IDA-mitochondrial inner membrane17008324
GO:0005743TAS-mitochondrial inner membrane14500729
GO:0005769IDA-early endosome24732013
GO:0005886IDA-plasma membrane24732013
GO:0005887IDA-integral component of plasma membrane15274632
GO:0009986IDA-cell surface22417827
GO:0016020IDA-membrane16210410
GO:0043209IEA-myelin sheath-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0000981IEA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0001850IDA-complement component C3a binding17070910
GO:0001851IDA-complement component C3b binding17070910
GO:0005515IPI-protein binding11302691
GO:0008022IPI-protein C-terminus binding19906925
GO:0019899IPI-enzyme binding23921388
GO:0031871IPI-proteinase activated receptor binding24732013
GO:0042826IPI-histone deacetylase binding16964284
GO:0044212IDA-transcription regulatory region DNA binding18487222
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter16964284
GO:0001649IDA-osteoblast differentiation16210410
GO:0006355IDA-regulation of transcription, DNA-templated14500729
GO:0006851TAS-mitochondrial calcium ion transmembrane transport-
GO:0007005IMP-mitochondrion organization17008324
GO:0007165TAS-signal transduction16130169
GO:0008285IMP-negative regulation of cell proliferation18487222
GO:0010628IGI-positive regulation of gene expression26310625
GO:0010942IGI-positive regulation of cell death26310625
GO:0010944IDA-negative regulation of transcription by competitive promoter binding18487222
GO:0016575IDA-histone deacetylation12466959
GO:0030308IMP-negative regulation of cell growth12065415
GO:0042177IMP-negative regulation of protein catabolic process24732013
GO:0042981TAS-regulation of apoptotic process16130169
GO:0045745IMP-positive regulation of G-protein coupled receptor protein signaling pathway24732013
GO:0045892IDA-negative regulation of transcription, DNA-templated12065415
GO:0045892IMP-negative regulation of transcription, DNA-templated18487222
GO:0045893IDA-positive regulation of transcription, DNA-templated14500729
GO:0045917IDA-positive regulation of complement activation17070910
GO:0050821IMP-protein stabilization17008324
GO:0050847IDA-progesterone receptor signaling pathway16964284
GO:0060766IDA-negative regulation of androgen receptor signaling pathway16964284
GO:0060766IMP-negative regulation of androgen receptor signaling pathway18487222
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade24732013
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade22417827
GO:0071354IDA-cellular response to interleukin-617324931
GO:0071897IEA-DNA biosynthetic process-
GO:2000323IDA-negative regulation of glucocorticoid receptor signaling pathway16964284
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PHBACTN111126412628297 Affinity Capture-Western
PHBACTN110660212628297 Affinity Capture-Western
PHBANXA211126412628297 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PHBANXA210679912628297 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PHBAR11126416964284 Affinity Capture-Western
PHBAR10686216964284 Affinity Capture-Western
PHBCLN311126420562859 Affinity Capture-MS
PHBCLN310761220562859 Affinity Capture-MS
PHBE2F111126410523633 12065415 14500729 14637159 15141164 Affinity Capture-Western; Co-localization; Reconstituted Complex
PHBE2F110820110523633 12065415 14500729 14637159 15141164 Affinity Capture-Western; Co-localization; Reconstituted Complex
PHBESR111126417932104 Reconstituted Complex
PHBESR110840317932104 Reconstituted Complex
PHBHDAC111126412466959 14637159 16964284 17932104 Affinity Capture-Western; Reconstituted Complex
PHBHDAC110931512466959 14637159 16964284 17932104 Affinity Capture-Western; Reconstituted Complex
PHBMGMT11126416226712 Affinity Capture-MS
PHBMGMT11041116226712 Affinity Capture-MS
PHBMYOD111126420195544 Affinity Capture-MS
PHBMYOD111073720195544 Affinity Capture-MS
RB1PHB11126410376528 10523633 16964284 Affinity Capture-Western; Reconstituted Complex
RB1PHB11186010376528 10523633 16964284 Affinity Capture-Western; Reconstituted Complex
RBL1PHB11126410376528 Affinity Capture-Western; Reconstituted Complex
RBL1PHB11186810376528 Affinity Capture-Western; Reconstituted Complex
RBL2PHB11126410376528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBL2PHB11186910376528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RAF1PHB11126410523633 Affinity Capture-Western; Reconstituted Complex
RAF1PHB11183110523633 Affinity Capture-Western; Reconstituted Complex
SMARCA2PHB11126412065415 15141164 Affinity Capture-Western
SMARCA2PHB11247912065415 15141164 Affinity Capture-Western
SMARCA4PHB11126412065415 15141164 Affinity Capture-Western
SMARCA4PHB11248112065415 15141164 Affinity Capture-Western
SIN3APHB11126412466959 Affinity Capture-Western
SIN3APHB11743912466959 Affinity Capture-Western
NCOR1PHB11126412466959 Affinity Capture-Western
NCOR1PHB11497312466959 Affinity Capture-Western
TP53PHB11126414500729 Affinity Capture-Western; Co-localization; Reconstituted Complex
TP53PHB11301014500729 Affinity Capture-Western; Co-localization; Reconstituted Complex
RNF2PHB11126417873902 Affinity Capture-Western
RNF2PHB11197217873902 Affinity Capture-Western
PHB2PHB11126417932104 Affinity Capture-Western
PHB2PHB11645917932104 Affinity Capture-Western
BREPHB11126419615732 Affinity Capture-MS
BREPHB11494619615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
RAF1PHB31250916041367 RAF1 (c-Raf) interacts with PHB.
SMARCA2PHB5491312065415 Prohibitin interacts with Brm.
SMARCA4PHB5491212065415 Prohibitin interacts with Brg-1
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:97572
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-6577'