AutismKB 2.0

Annotation Details for SERPINA1


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Basic Information Top
Gene Symbol:SERPINA1 ( A1A,A1AT,AAT,MGC23330,MGC9222,PI,PI1,PRO2275,alpha1AT )
Gene Full Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Band: 14q32.13
Quick LinksEntrez ID:5265; OMIM: 107400; Uniprot ID:A1AT_HUMAN; ENSEMBL ID: ENSG00000197249; HGNC ID: 8941
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139IEA-Golgi membrane-
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005578IEA-proteinaceous extracellular matrix-
GO:0005615IDA-extracellular space6980881
GO:0005615IMP-extracellular space16192646
GO:0005783IDA-endoplasmic reticulum20477988
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005794IDA-Golgi apparatus20477988
GO:0030134TAS-ER to Golgi transport vesicle-
GO:0031093TAS-platelet alpha granule lumen-
GO:0033116TAS-endoplasmic reticulum-Golgi intermediate compartment membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding20477988
GO:0002020IPI-protease binding15853774
GO:0004867IDA-serine-type endopeptidase inhibitor activity15795238
GO:0004867NAS-serine-type endopeptidase inhibitor activity12878203
GO:0005515IPI-protein binding11057674
GO:0042802IPI-identical protein binding11057674
GO ID Evidence Qualifier GO_term References
GO:0002576TAS-platelet degranulation-
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0006953IEA-acute-phase response-
GO:0007596IEA-blood coagulation-
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0043312TAS-neutrophil degranulation-
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0048208TAS-COPII vesicle coating-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SERPINA1KLK31068501702714 Affinity Capture-Western
SERPINA1KLK31112831702714 Affinity Capture-Western
SERPINA1ELANE11128310867014 Reconstituted Complex
SERPINA1ELANE10830610867014 Reconstituted Complex
PRTN3SERPINA111128312114510 Biochemical Activity
PRTN3SERPINA111163812114510 Biochemical Activity
KLK13SERPINA111128314687906 Reconstituted Complex
KLK13SERPINA111753814687906 Reconstituted Complex
UBCSERPINA111128316979136 Affinity Capture-Western
UBCSERPINA111316416979136 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SERPINA1PI Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
SERPINA1SERPINA1_phenotype Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:891967
  • Data Attributes: HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-1421'