AutismKB 2.0

Annotation Details for SERPINE2


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Basic Information Top
Gene Symbol:SERPINE2 ( DKFZp686A13110,GDN,PI-7,PI7,PN-1,PN1,PNI )
Gene Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Band: 2q36.1
Quick LinksEntrez ID:5270; OMIM: 177010; Uniprot ID:GDN_HUMAN; ENSEMBL ID: ENSG00000135919; HGNC ID: 8951
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region3997857
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005829IDA-cytosol19855083
GO:0031012IDA-extracellular matrix3279057
GO:0031091IDA-platelet alpha granule19855083
GO:0031091IMP-platelet alpha granule19855083
GO:0031232IDA-extrinsic component of external side of plasma membrane19855083
GO:0031594ISS-neuromuscular junction2037625
GO:1903561IDA-extracellular vesicle24769233
GO ID Evidence Qualifier GO_term References
GO:0004867IDA-serine-type endopeptidase inhibitor activity3997857
GO:0004867IMP-serine-type endopeptidase inhibitor activity19855083
GO:0005102IPI-receptor binding17379830
GO:0005515IPI-protein binding3279057
GO:0005539IDA-glycosaminoglycan binding19855083
GO:0008201IDA-heparin binding1939253
GO ID Evidence Qualifier GO_term References
GO:0007596TAS-blood coagulation-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0010757IMP-negative regulation of plasminogen activation19855083
GO:0010766IEA-negative regulation of sodium ion transport-
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0010955IC-negative regulation of protein processing19855083
GO:0014067IEA-negative regulation of phosphatidylinositol 3-kinase signaling-
GO:0021683IEA-cerebellar granular layer morphogenesis-
GO:0030195IC-negative regulation of blood coagulation19855083
GO:0030195IDA-negative regulation of blood coagulation17379830
GO:0030308IEA-negative regulation of cell growth-
GO:0030334NAS-regulation of cell migration2877744
GO:0032940IEA-secretion by cell-
GO:0033363IEA-secretory granule organization-
GO:0042177IEA-negative regulation of protein catabolic process-
GO:0042628IEA-mating plug formation-
GO:0045861IDA-negative regulation of proteolysis3997857
GO:0045879IEA-negative regulation of smoothened signaling pathway-
GO:0048505IEA-regulation of timing of cell differentiation-
GO:0048711IDA-positive regulation of astrocyte differentiation1691280
GO:0050974IEA-detection of mechanical stimulus involved in sensory perception-
GO:0051966IEA-regulation of synaptic transmission, glutamatergic-
GO:0060291IEA-long-term synaptic potentiation-
GO:0060384IEA-innervation-
GO:0061108IEA-seminal vesicle epithelium development-
GO:0090331ISS-negative regulation of platelet aggregation19855083
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PLAUSERPINE21113449184208 Reconstituted Complex
PLAUSERPINE21112889184208 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101780
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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