AutismKB 2.0

Annotation Details for PIK3CA


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Basic Information Top
Gene Symbol:PIK3CA ( MGC142161,MGC142163,PI3K,p110-alpha )
Gene Full Name: phosphoinositide-3-kinase, catalytic, alpha polypeptide
Band: 3q26.32
Quick LinksEntrez ID:5290; OMIM: 171834; Uniprot ID:PK3CA_HUMAN; ENSEMBL ID: ENSG00000121879; HGNC ID: 8975
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0005886IBA-plasma membrane-
GO:0005942ISS-phosphatidylinositol 3-kinase complex-
GO:0005943IDA-phosphatidylinositol 3-kinase complex, class IA22402981
GO:0030027IEA-lamellipodium-
GO ID Evidence Qualifier GO_term References
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding10490823
GO:0005524IEA-ATP binding-
GO:0016301IDA-kinase activity25327288
GO:0016301TAS-kinase activity-
GO:0016303IDA-1-phosphatidylinositol-3-kinase activity2174051
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0030295IEA-protein kinase activator activity-
GO:0035004ISS-phosphatidylinositol 3-kinase activity-
GO:0035004TAS-phosphatidylinositol 3-kinase activity19200708
GO:0035005IBA-1-phosphatidylinositol-4-phosphate 3-kinase activity-
GO:0043560IEA-insulin receptor substrate binding-
GO:0046934IBA-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001889IEA-liver development-
GO:0001944TAS-vasculature development19200708
GO:0006006IEA-glucose metabolic process-
GO:0006468IEA-protein phosphorylation-
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007411TAS-axon guidance-
GO:0010468IEA-regulation of gene expression-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0016242NAS-negative regulation of macroautophagy23778976
GO:0016310IDA-phosphorylation25327288
GO:0030168TAS-platelet activation21035500
GO:0031295TAS-T cell costimulation-
GO:0032008NAS-positive regulation of TOR signaling23778976
GO:0032147IEA-activation of protein kinase activity-
GO:0033138IEA-positive regulation of peptidyl-serine phosphorylation-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0038028TAS-insulin receptor signaling pathway via phosphatidylinositol 3-kinase19200708
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0040014IEA-regulation of multicellular organism growth-
GO:0043276NAS-anoikis23778976
GO:0043457IEA-regulation of cellular respiration-
GO:0043491IEA-protein kinase B signaling-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043542TAS-endothelial cell migration19200708
GO:0044029IEA-hypomethylation of CpG island-
GO:0046854ISS-phosphatidylinositol phosphorylation-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
GO:0060048TAS-cardiac muscle contraction19147653
GO:0060612IEA-adipose tissue development-
GO:0071333IEA-cellular response to glucose stimulus-
GO:0097009IEA-energy homeostasis-
GO:2000270IEA-negative regulation of fibroblast apoptotic process-
GO:2000653IEA-regulation of genetic imprinting-
GO:2000811IMP-negative regulation of anoikis22402981
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PIK3CAATR10702710608806 Protein-peptide
PIK3CAATR11130810608806 Protein-peptide
PIK3CACBL1073158641358 Co-purification
PIK3CACBL1113088641358 Co-purification
PIK3CAGNAQ10903812704201 Affinity Capture-Western
PIK3CAGNAQ11130812704201 Affinity Capture-Western
PIK3CAGSN10918911577104 Affinity Capture-Western
PIK3CAGSN11130811577104 Affinity Capture-Western
PIK3CAHRAS1095018665852 10783161 14724584 Reconstituted Complex; Two-hybrid
PIK3CAHRAS1113088665852 10783161 14724584 Reconstituted Complex; Two-hybrid
PIK3CAIRS110987416354680 Affinity Capture-Western
PIK3CAIRS111130816354680 Affinity Capture-Western
PIK3CAKRAS11004310783161 Two-hybrid
PIK3CAKRAS11130810783161 Two-hybrid
PIK3CALCK1101248246987 14583609 Affinity Capture-Western; Reconstituted Complex
PIK3CALCK1113088246987 14583609 Affinity Capture-Western; Reconstituted Complex
PIK3CANOTCH111091314583609 Affinity Capture-Western
PIK3CANOTCH111130814583609 Affinity Capture-Western
PIK3R1PIK3CA1113137929193 Reconstituted Complex
PIK3R1PIK3CA1113087929193 Reconstituted Complex
PIK3R3PIK3CA1140759415396 Two-hybrid
PIK3R3PIK3CA1113089415396 Two-hybrid
SGK1PIK3CA11234410357815 Reconstituted Complex
SGK1PIK3CA11130810357815 Reconstituted Complex
IRS4PIK3CA11130811912194 Affinity Capture-MS
IRS4PIK3CA11404811912194 Affinity Capture-MS
YWHAHPIK3CA11130811969417 Affinity Capture-Western
YWHAHPIK3CA11336511969417 Affinity Capture-Western
ARHGEF1PIK3CA11130812754211 Affinity Capture-Western
ARHGEF1PIK3CA11458512754211 Affinity Capture-Western
DGKZPIK3CA11409512890670 Affinity Capture-Western; Biochemical Activity
DGKZPIK3CA11130812890670 Affinity Capture-Western; Biochemical Activity
ADAP1PIK3CA11622212893243 Biochemical Activity; Reconstituted Complex
ADAP1PIK3CA11130812893243 Biochemical Activity; Reconstituted Complex
SLC9A3R2PIK3CA11475412954600 Reconstituted Complex
SLC9A3R2PIK3CA11130812954600 Reconstituted Complex
SLC9A3R1PIK3CA11476912954600 Reconstituted Complex
SLC9A3R1PIK3CA11130812954600 Reconstituted Complex
RASD2PIK3CA11130814724584 Reconstituted Complex
RASD2PIK3CA11709514724584 Reconstituted Complex
RASGRP3PIK3CA11731515213298 Biochemical Activity
RASGRP3PIK3CA11130815213298 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1206581
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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