Gene Symbol:	PIK3CA ( MGC142161,MGC142163,PI3K,p110-alpha )
Gene Full Name:	phosphoinositide-3-kinase, catalytic, alpha polypeptide
Band:	3q26.32
Quick Links	Entrez ID:5290; OMIM: 171834; Uniprot ID:PK3CA_HUMAN; ENSEMBL ID: ENSG00000121879; HGNC ID: 8975
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005829	TAS	-	cytosol	-
GO:0005886	IBA	-	plasma membrane	-
GO:0005942	ISS	-	phosphatidylinositol 3-kinase complex	-
GO:0005943	IDA	-	phosphatidylinositol 3-kinase complex, class IA	22402981
GO:0030027	IEA	-	lamellipodium	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004674	IEA	-	protein serine/threonine kinase activity	-
GO:0005515	IPI	-	protein binding	10490823
GO:0005524	IEA	-	ATP binding	-
GO:0016301	IDA	-	kinase activity	25327288
GO:0016301	TAS	-	kinase activity	-
GO:0016303	IDA	-	1-phosphatidylinositol-3-kinase activity	2174051
GO:0016303	TAS	-	1-phosphatidylinositol-3-kinase activity	-
GO:0030295	IEA	-	protein kinase activator activity	-
GO:0035004	ISS	-	phosphatidylinositol 3-kinase activity	-
GO:0035004	TAS	-	phosphatidylinositol 3-kinase activity	19200708
GO:0035005	IBA	-	1-phosphatidylinositol-4-phosphate 3-kinase activity	-
GO:0043560	IEA	-	insulin receptor substrate binding	-
GO:0046934	IBA	-	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-
GO:0046934	TAS	-	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001525	IEA	-	angiogenesis	-
GO:0001889	IEA	-	liver development	-
GO:0001944	TAS	-	vasculature development	19200708
GO:0006006	IEA	-	glucose metabolic process	-
GO:0006468	IEA	-	protein phosphorylation	-
GO:0006661	TAS	-	phosphatidylinositol biosynthetic process	-
GO:0007173	TAS	-	epidermal growth factor receptor signaling pathway	-
GO:0007411	TAS	-	axon guidance	-
GO:0010468	IEA	-	regulation of gene expression	-
GO:0014066	TAS	-	regulation of phosphatidylinositol 3-kinase signaling	-
GO:0016242	NAS	-	negative regulation of macroautophagy	23778976
GO:0016310	IDA	-	phosphorylation	25327288
GO:0030168	TAS	-	platelet activation	21035500
GO:0031295	TAS	-	T cell costimulation	-
GO:0032008	NAS	-	positive regulation of TOR signaling	23778976
GO:0032147	IEA	-	activation of protein kinase activity	-
GO:0033138	IEA	-	positive regulation of peptidyl-serine phosphorylation	-
GO:0036092	IEA	-	phosphatidylinositol-3-phosphate biosynthetic process	-
GO:0038028	TAS	-	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	19200708
GO:0038095	TAS	-	Fc-epsilon receptor signaling pathway	-
GO:0038096	TAS	-	Fc-gamma receptor signaling pathway involved in phagocytosis	-
GO:0038128	TAS	-	ERBB2 signaling pathway	-
GO:0040014	IEA	-	regulation of multicellular organism growth	-
GO:0043276	NAS	-	anoikis	23778976
GO:0043457	IEA	-	regulation of cellular respiration	-
GO:0043491	IEA	-	protein kinase B signaling	-
GO:0043524	IEA	-	negative regulation of neuron apoptotic process	-
GO:0043542	TAS	-	endothelial cell migration	19200708
GO:0044029	IEA	-	hypomethylation of CpG island	-
GO:0046854	ISS	-	phosphatidylinositol phosphorylation	-
GO:0048010	TAS	-	vascular endothelial growth factor receptor signaling pathway	-
GO:0048015	TAS	-	phosphatidylinositol-mediated signaling	-
GO:0050852	TAS	-	T cell receptor signaling pathway	-
GO:0050900	TAS	-	leukocyte migration	-
GO:0060048	TAS	-	cardiac muscle contraction	19147653
GO:0060612	IEA	-	adipose tissue development	-
GO:0071333	IEA	-	cellular response to glucose stimulus	-
GO:0097009	IEA	-	energy homeostasis	-
GO:2000270	IEA	-	negative regulation of fibroblast apoptotic process	-
GO:2000653	IEA	-	regulation of genetic imprinting	-
GO:2000811	IMP	-	negative regulation of anoikis	22402981

Gene Symbol	Interactant	Interaction ID	References	Description
PIK3CA	ATR	107027	10608806	Protein-peptide
PIK3CA	ATR	111308	10608806	Protein-peptide
PIK3CA	CBL	107315	8641358	Co-purification
PIK3CA	CBL	111308	8641358	Co-purification
PIK3CA	GNAQ	109038	12704201	Affinity Capture-Western
PIK3CA	GNAQ	111308	12704201	Affinity Capture-Western
PIK3CA	GSN	109189	11577104	Affinity Capture-Western
PIK3CA	GSN	111308	11577104	Affinity Capture-Western
PIK3CA	HRAS	109501	8665852 10783161 14724584	Reconstituted Complex; Two-hybrid
PIK3CA	HRAS	111308	8665852 10783161 14724584	Reconstituted Complex; Two-hybrid
PIK3CA	IRS1	109874	16354680	Affinity Capture-Western
PIK3CA	IRS1	111308	16354680	Affinity Capture-Western
PIK3CA	KRAS	110043	10783161	Two-hybrid
PIK3CA	KRAS	111308	10783161	Two-hybrid
PIK3CA	LCK	110124	8246987 14583609	Affinity Capture-Western; Reconstituted Complex
PIK3CA	LCK	111308	8246987 14583609	Affinity Capture-Western; Reconstituted Complex
PIK3CA	NOTCH1	110913	14583609	Affinity Capture-Western
PIK3CA	NOTCH1	111308	14583609	Affinity Capture-Western
PIK3R1	PIK3CA	111313	7929193	Reconstituted Complex
PIK3R1	PIK3CA	111308	7929193	Reconstituted Complex
PIK3R3	PIK3CA	114075	9415396	Two-hybrid
PIK3R3	PIK3CA	111308	9415396	Two-hybrid
SGK1	PIK3CA	112344	10357815	Reconstituted Complex
SGK1	PIK3CA	111308	10357815	Reconstituted Complex
IRS4	PIK3CA	111308	11912194	Affinity Capture-MS
IRS4	PIK3CA	114048	11912194	Affinity Capture-MS
YWHAH	PIK3CA	111308	11969417	Affinity Capture-Western
YWHAH	PIK3CA	113365	11969417	Affinity Capture-Western
ARHGEF1	PIK3CA	111308	12754211	Affinity Capture-Western
ARHGEF1	PIK3CA	114585	12754211	Affinity Capture-Western
DGKZ	PIK3CA	114095	12890670	Affinity Capture-Western; Biochemical Activity
DGKZ	PIK3CA	111308	12890670	Affinity Capture-Western; Biochemical Activity
ADAP1	PIK3CA	116222	12893243	Biochemical Activity; Reconstituted Complex
ADAP1	PIK3CA	111308	12893243	Biochemical Activity; Reconstituted Complex
SLC9A3R2	PIK3CA	114754	12954600	Reconstituted Complex
SLC9A3R2	PIK3CA	111308	12954600	Reconstituted Complex
SLC9A3R1	PIK3CA	114769	12954600	Reconstituted Complex
SLC9A3R1	PIK3CA	111308	12954600	Reconstituted Complex
RASD2	PIK3CA	111308	14724584	Reconstituted Complex
RASD2	PIK3CA	117095	14724584	Reconstituted Complex
RASGRP3	PIK3CA	117315	15213298	Biochemical Activity
RASGRP3	PIK3CA	111308	15213298	Biochemical Activity

AutismKB 2.0

Annotation Details for PIK3CA

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Syndromic Genes

Non-syndromic Genes

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