AutismKB 2.0

Annotation Details for PIK3CG


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Basic Information Top
Gene Symbol:PIK3CG ( PI3CG,PI3K,PI3Kgamma,PIK3 )
Gene Full Name: phosphoinositide-3-kinase, catalytic, gamma polypeptide
Band: 7q22.3
Quick LinksEntrez ID:5294; OMIM: 601232; Uniprot ID:PK3CG_HUMAN; ENSEMBL ID: ENSG00000105851; HGNC ID: 8978
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm12507995
GO:0005829TAS-cytosol-
GO:0005886IBA-plasma membrane-
GO:0005886IDA-plasma membrane-
GO:0005944IDA-phosphatidylinositol 3-kinase complex, class IB12507995
GO:0016020IDA-membrane12507995
GO:0042629IEA-mast cell granule-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity19376709
GO:0004674IEA-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding12507995
GO:0005524IEA-ATP binding-
GO:0016301IDA-kinase activity25327288
GO:0016303IBA-1-phosphatidylinositol-3-kinase activity-
GO:0035004TAS-phosphatidylinositol 3-kinase activity17290298
GO:0035005IBA-1-phosphatidylinositol-4-phosphate 3-kinase activity-
GO:0046875IPI-ephrin receptor binding11416136
GO:0046934IBA-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001816TAS-cytokine production19075988
GO:0002250TAS-adaptive immune response17290298
GO:0002407TAS-dendritic cell chemotaxis18278175
GO:0002675IEA-positive regulation of acute inflammatory response-
GO:0002679TAS-respiratory burst involved in defense response19075988
GO:0006468IEA-protein phosphorylation-
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0006897IEA-endocytosis-
GO:0006954TAS-inflammatory response17290298
GO:0007186IDA-G-protein coupled receptor signaling pathway12507995
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0010818TAS-T cell chemotaxis18278175
GO:0010897IEA-negative regulation of triglyceride catabolic process-
GO:0014065IDA-phosphatidylinositol 3-kinase signaling12507995
GO:0014065TAS-phosphatidylinositol 3-kinase signaling17290298
GO:0016310IDA-phosphorylation25327288
GO:0030168TAS-platelet activation-
GO:0030593TAS-neutrophil chemotaxis17290298
GO:0032252IEA-secretory granule localization-
GO:0033628TAS-regulation of cell adhesion mediated by integrin18278175
GO:0035747TAS-natural killer cell chemotaxis18278175
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042098TAS-T cell proliferation19075988
GO:0042110TAS-T cell activation17290298
GO:0043303TAS-mast cell degranulation17290298
GO:0043406IDA-positive regulation of MAP kinase activity12507995
GO:0045087TAS-innate immune response17290298
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0051897IDA-positive regulation of protein kinase B signaling12507995
GO:0055118TAS-negative regulation of cardiac muscle contraction19147653
GO:0070527TAS-platelet aggregation21035500
GO:0071320IEA-cellular response to cAMP-
GO:0072672TAS-neutrophil extravasation18278175
GO:0097284IEA-hepatocyte apoptotic process-
GO:1903169IEA-regulation of calcium ion transmembrane transport-
GO:2000270IEA-negative regulation of fibroblast apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PIK3CGBCR1113127606002 8641358 9747873 Affinity Capture-Western; Co-purification; Two-hybrid
PIK3CGBCR1070837606002 8641358 9747873 Affinity Capture-Western; Co-purification; Two-hybrid
PIK3CGEPHA811131211416136 Affinity Capture-Western
PIK3CGEPHA810836011416136 Affinity Capture-Western
PIK3CGHRAS10950111136978 Co-crystal Structure
PIK3CGHRAS11131211136978 Co-crystal Structure
PIK3CGERAS10950212774123 Affinity Capture-Western
PIK3CGERAS11131212774123 Affinity Capture-Western
PIK3CGKRAS11131210542052 Affinity Capture-Western; Reconstituted Complex
PIK3CGKRAS11004310542052 Affinity Capture-Western; Reconstituted Complex
PIK3CGLYN11024510318860 Affinity Capture-Western
PIK3CGLYN11131210318860 Affinity Capture-Western
PIK3CGNRAS11095211136978 Reconstituted Complex
PIK3CGNRAS11131211136978 Reconstituted Complex
PIK3CGPIK3CD1113119113989 Affinity Capture-Western; Reconstituted Complex
PIK3CGPIK3CD1113129113989 Affinity Capture-Western; Reconstituted Complex
PIK3R5PIK3CG11131212507995 Co-fractionation; Co-localization; FRET; Phenotypic Enhancement
PIK3R5PIK3CG11707912507995 Co-fractionation; Co-localization; FRET; Phenotypic Enhancement
USP45PIK3CG12443019615732 Affinity Capture-MS
USP45PIK3CG11131219615732 Affinity Capture-MS
GABARAPL1PIK3CG11131220562859 Affinity Capture-MS
GABARAPL1PIK3CG11722320562859 Affinity Capture-MS
PRMT7PIK3CG11131220562859 Affinity Capture-MS
PRMT7PIK3CG11999220562859 Affinity Capture-MS
PRKAA2PIK3CG11131220562859 Affinity Capture-MS
PRKAA2PIK3CG11155020562859 Affinity Capture-MS
UTRNPIK3CG11131220562859 Affinity Capture-MS
UTRNPIK3CG11324520562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PIK3CGrs1526083, rs849404 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1353576
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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