AutismKB 2.0

Annotation Details for PIK3R2


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Basic Information Top
Gene Symbol:PIK3R2 ( P85B,p85,p85-BETA )
Gene Full Name: phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Band: 19p13.11
Quick LinksEntrez ID:5296; OMIM: 603157; Uniprot ID:P85B_HUMAN; ENSEMBL ID: ENSG00000105647; HGNC ID: 8980
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005829TAS-cytosol-
GO:0005942IBA-phosphatidylinositol 3-kinase complex-
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0005096TAS-GTPase activator activity-
GO:0005515IPI-protein binding7537096
GO:0016303ISScontributes_to1-phosphatidylinositol-3-kinase activity-
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0019903IPI-protein phosphatase binding23604317
GO:0030971IPI-receptor tyrosine kinase binding10627473
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0046935IBA-1-phosphatidylinositol-3-kinase regulator activity-
GO:0046982ISS-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0001678ISS-cellular glucose homeostasis-
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0008286IBA-insulin receptor signaling pathway-
GO:0010506IMP-regulation of autophagy23604317
GO:0014065IDA-phosphatidylinositol 3-kinase signaling23604317
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0015031IEA-protein transport-
GO:0032869ISS-cellular response to insulin stimulus-
GO:0034976ISS-response to endoplasmic reticulum stress-
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0042993ISS-positive regulation of transcription factor import into nucleus-
GO:0043065ISS-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043551IBA-regulation of phosphatidylinositol 3-kinase activity-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046854IBA-phosphatidylinositol phosphorylation-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:2001275ISS-positive regulation of glucose import in response to insulin stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PIK3R2AXL1113149178760 Biochemical Activity
PIK3R2AXL1070369178760 Biochemical Activity
PIK3R2CBL1073157629144 11133830 15107835 Affinity Capture-MS; Affinity Capture-Western
PIK3R2CBL1113147629144 11133830 15107835 Affinity Capture-MS; Affinity Capture-Western
PIK3R2CCR511131411350939 Affinity Capture-Western
PIK3R2CCR510763911350939 Affinity Capture-Western
PIK3R2CRKL1077899092574 Affinity Capture-Western; Far Western
PIK3R2CRKL1113149092574 Affinity Capture-Western; Far Western
PIK3R2CSF11078221334406 Biochemical Activity; Reconstituted Complex
PIK3R2CSF11113141334406 Biochemical Activity; Reconstituted Complex
PIK3R2EGF1113141334406 Biochemical Activity; Reconstituted Complex
PIK3R2EGF1082701334406 Biochemical Activity; Reconstituted Complex
PIK3R2ERBB21113141334406 Biochemical Activity; Reconstituted Complex
PIK3R2ERBB21083761334406 Biochemical Activity; Reconstituted Complex
PIK3R2ERBB311131416729043 Affinity Capture-MS
PIK3R2ERBB310837716729043 Affinity Capture-MS
PIK3R2ERBB411131416729043 Affinity Capture-MS
PIK3R2ERBB410837816729043 Affinity Capture-MS
PIK3R2FYN1088101334406 Biochemical Activity; Reconstituted Complex
PIK3R2FYN1113141334406 Biochemical Activity; Reconstituted Complex
PIK3R2GRB210914220936779 Two-hybrid
PIK3R2GRB211131420936779 Two-hybrid
PIK3R2KIT11001510022833 Two-hybrid
PIK3R2KIT11131410022833 Two-hybrid
PIK3R2PIK3CD1113119113989 Affinity Capture-Western; Reconstituted Complex
PIK3R2PIK3CD1113149113989 Affinity Capture-Western; Reconstituted Complex
TECPIK3R21113149178903 Two-hybrid
TECPIK3R21128659178903 Two-hybrid
TGFBR1PIK3R21113149435577 Affinity Capture-Western
TGFBR1PIK3R21129049435577 Affinity Capture-Western
TGFBR2PIK3R21129069435577 Affinity Capture-Western
TGFBR2PIK3R21113149435577 Affinity Capture-Western
SOCS6PIK3R211471912052866 Affinity Capture-MS
SOCS6PIK3R211131412052866 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
PIK3R2FGFR125965315117958 An unspecified isoform of FGFR1 interacts with p85-beta. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human p85-beta.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
PIK3R2rs2267922, rs273276, rs3736328 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1098772
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040309-1'